dbPTM

CEP95_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CEP95_HUMAN
UniProt AC	Q96GE4
Protein Name	Centrosomal protein of 95 kDa
Gene Name	CEP95
Organism	Homo sapiens (Human).
Sequence Length	821
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
Protein Description
Protein Sequence	MAGSDAEWVTIANNLLFKCHIHLRIHELQDCDANVFIALYQSILGEKVPDLIVIPRSQEDDAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKESIKNLLEIFDGLLEYLTERISETSHEKSETEQYFKESDRGERLEEPESTKESKSSWKRVSFGRCSLSSEMLGPSWDGDEAESTGEIIRLGDTAHTFSLRSNGAQCPNEMLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVNSTGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRSKMEKEIQQLQDMITQNDDDVFFRELEAERFRSRLQLASFQYSKSPSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	IALYQSILGEKVPDL HHHHHHHHCCCCCCE	9.80	-
66	Ubiquitination	EDDAHNVQAVIDSLA CCCCHHHHHHHHHHH	34.92	-
66	Ubiquitination	EDDAHNVQAVIDSLA CCCCHHHHHHHHHHH	34.92	29967540
88	Ubiquitination	LSHITGENIVKGDKE HHHHCCCCCCCCCHH	45.78	29967540
105	Ubiquitination	KNLLEIFDGLLEYLT HHHHHHHHHHHHHHH	53.11	22817900
108	Ubiquitination	LEIFDGLLEYLTERI HHHHHHHHHHHHHHH	5.07	21890473
116	Phosphorylation	EYLTERISETSHEKS HHHHHHHHHCCCCHH	40.83	27732954
118	Phosphorylation	LTERISETSHEKSET HHHHHHHCCCCHHHH	28.70	27732954
119	Phosphorylation	TERISETSHEKSETE HHHHHHCCCCHHHHH	26.12	27732954
123	Phosphorylation	SETSHEKSETEQYFK HHCCCCHHHHHHHHH	46.93	21815630
125	Phosphorylation	TSHEKSETEQYFKES CCCCHHHHHHHHHHC	35.16	20873877
128	Phosphorylation	EKSETEQYFKESDRG CHHHHHHHHHHCCCC	15.47	21406692
130	Ubiquitination	SETEQYFKESDRGER HHHHHHHHHCCCCCC	51.91	-
132	Phosphorylation	TEQYFKESDRGERLE HHHHHHHCCCCCCCC	32.95	30622161
145	Ubiquitination	LEEPESTKESKSSWK CCCCCCCCCCHHHCC	70.08	21906983
148	Ubiquitination	PESTKESKSSWKRVS CCCCCCCHHHCCEEE	49.99	22817900
150	Ubiquitination	STKESKSSWKRVSFG CCCCCHHHCCEEEEC	40.11	-
150	Ubiquitination	STKESKSSWKRVSFG CCCCCHHHCCEEEEC	40.11	29967540
153	Ubiquitination	ESKSSWKRVSFGRCS CCHHHCCEEEECCCC	24.05	22817900
155	Phosphorylation	KSSWKRVSFGRCSLS HHHCCEEEECCCCCC	26.47	20860994
156	Ubiquitination	SSWKRVSFGRCSLSS HHCCEEEECCCCCCC	7.00	-
156	Ubiquitination	SSWKRVSFGRCSLSS HHCCEEEECCCCCCC	7.00	21890473
162	Ubiquitination	SFGRCSLSSEMLGPS EECCCCCCCHHHCCC	14.14	22817900
175	Ubiquitination	PSWDGDEAESTGEII CCCCCCCHHCCCCEE	22.30	22817900
187	Phosphorylation	EIIRLGDTAHTFSLR CEEEECCCEEEEECC	20.66	23312004
190	Phosphorylation	RLGDTAHTFSLRSNG EECCCEEEEECCCCC	16.68	23312004
192	Phosphorylation	GDTAHTFSLRSNGAQ CCCEEEEECCCCCCC	24.83	23312004
206	Phosphorylation	QCPNEMLSKKALASP CCCHHHHCHHCCCCC	30.69	24425749
208	Ubiquitination	PNEMLSKKALASPSS CHHHHCHHCCCCCCC	45.30	-
210	Ubiquitination	EMLSKKALASPSSKS HHHCHHCCCCCCCCC	7.14	-
210	Ubiquitination	EMLSKKALASPSSKS HHHCHHCCCCCCCCC	7.14	22817900
212	Phosphorylation	LSKKALASPSSKSHE HCHHCCCCCCCCCHH	26.60	28985074
214	Phosphorylation	KKALASPSSKSHEDM HHCCCCCCCCCHHHH	48.15	28102081
215	Phosphorylation	KALASPSSKSHEDML HCCCCCCCCCHHHHC	41.37	28102081
217	Phosphorylation	LASPSSKSHEDMLYP CCCCCCCCHHHHCCC	33.77	25159151
223	Ubiquitination	KSHEDMLYPPSVLSK CCHHHHCCCHHHHCC	13.37	-
223	Phosphorylation	KSHEDMLYPPSVLSK CCHHHHCCCHHHHCC	13.37	27732954
223	Ubiquitination	KSHEDMLYPPSVLSK CCHHHHCCCHHHHCC	13.37	22817900
226	Phosphorylation	EDMLYPPSVLSKSRT HHHCCCHHHHCCCCC	31.05	28450419
229	Phosphorylation	LYPPSVLSKSRTSFV CCCHHHHCCCCCCCC	26.82	28450419
230	Ubiquitination	YPPSVLSKSRTSFVE CCHHHHCCCCCCCCC	39.53	29967540
231	Phosphorylation	PPSVLSKSRTSFVED CHHHHCCCCCCCCCC	37.10	27251275
233	Phosphorylation	SVLSKSRTSFVEDTE HHHCCCCCCCCCCCC	33.34	27251275
234	Phosphorylation	VLSKSRTSFVEDTET HHCCCCCCCCCCCCC	26.61	29449344
239	Phosphorylation	RTSFVEDTETLSVSG CCCCCCCCCCEEECC	19.84	28122231
241	Phosphorylation	SFVEDTETLSVSGIP CCCCCCCCEEECCCC	26.82	30576142
243	Phosphorylation	VEDTETLSVSGIPNA CCCCCCEEECCCCCH	22.96	30576142
245	Phosphorylation	DTETLSVSGIPNARK CCCCEEECCCCCHHH	27.85	28122231
252	Ubiquitination	SGIPNARKLGEPIRA CCCCCHHHCCCCCEE	59.44	29967540
287	Phosphorylation	KEYLHSSHCSPAVNS HHHHCCCCCCCCCCC	21.06	33259812
314	Ubiquitination	DGLFLISKLPKGSKW CCEEEEEECCCCCCC	62.91	29967540
317	Ubiquitination	FLISKLPKGSKWEVY EEEEECCCCCCCEEE	83.01	22817900
320	Ubiquitination	SKLPKGSKWEVYPAQ EECCCCCCCEEEECC	56.92	21890473
320	Ubiquitination	SKLPKGSKWEVYPAQ EECCCCCCCEEEECC	56.92	21906983
332	Ubiquitination	PAQVQGPRTRKPPKG ECCCCCCCCCCCCCC	54.72	-
332	Ubiquitination	PAQVQGPRTRKPPKG ECCCCCCCCCCCCCC	54.72	29967540
333	Phosphorylation	AQVQGPRTRKPPKGK CCCCCCCCCCCCCCC	46.29	-
341	Dimethylation	RKPPKGKRNENRATA CCCCCCCCCCCCCCH	65.45	-
347	Phosphorylation	KRNENRATASSCNSP CCCCCCCCHHHCCCC	24.68	27732954
349	Phosphorylation	NENRATASSCNSPFP CCCCCCHHHCCCCCC	30.94	25159151
350	Phosphorylation	ENRATASSCNSPFPQ CCCCCHHHCCCCCCC	18.17	24719451
353	Phosphorylation	ATASSCNSPFPQRPR CCHHHCCCCCCCCCC	32.04	28985074
360	Ubiquitination	SPFPQRPRKRLTEQE CCCCCCCCCCCCHHH	38.63	-
360	Ubiquitination	SPFPQRPRKRLTEQE CCCCCCCCCCCCHHH	38.63	29967540
364	Phosphorylation	QRPRKRLTEQELHDV CCCCCCCCHHHHHHH	39.39	24247654
370	Ubiquitination	LTEQELHDVSEKLSQ CCHHHHHHHHHHHHH	59.26	29967540
374	Ubiquitination	ELHDVSEKLSQRLSE HHHHHHHHHHHHHHH	46.03	21906983
386	Ubiquitination	LSELDWMLKSALGDR HHHHHHHHHHHHHHH	3.27	22817900
387	Sumoylation	SELDWMLKSALGDRI HHHHHHHHHHHHHHH	19.99	-
387	Ubiquitination	SELDWMLKSALGDRI HHHHHHHHHHHHHHH	19.99	21906983
388	Phosphorylation	ELDWMLKSALGDRIK HHHHHHHHHHHHHHH	25.43	25159151
405	Phosphorylation	TDHKEENTGNEEVED CCCCCCCCCCCCCCC	44.67	21406692
414	Phosphorylation	NEEVEDGTEETLSQH CCCCCCCCHHHHHHC	42.86	30576142
417	Phosphorylation	VEDGTEETLSQHSDG CCCCCHHHHHHCCCC	26.02	30576142
419	Phosphorylation	DGTEETLSQHSDGIV CCCHHHHHHCCCCCE	33.01	25849741
422	Phosphorylation	EETLSQHSDGIVEYG HHHHHHCCCCCEECC	29.87	25849741
424	Ubiquitination	TLSQHSDGIVEYGPK HHHHCCCCCEECCCC	28.93	-
424	Ubiquitination	TLSQHSDGIVEYGPK HHHHCCCCCEECCCC	28.93	29967540
428	Phosphorylation	HSDGIVEYGPKKSRP CCCCCEECCCCCCCC	28.03	21406692
433	Phosphorylation	VEYGPKKSRPGLSMR EECCCCCCCCCCCCC	50.24	22210691
434	Ubiquitination	EYGPKKSRPGLSMRR ECCCCCCCCCCCCCC	37.88	-
434	Ubiquitination	EYGPKKSRPGLSMRR ECCCCCCCCCCCCCC	37.88	22817900
435	Ubiquitination	YGPKKSRPGLSMRRK CCCCCCCCCCCCCCC	55.99	22817900
442	Methylation	PGLSMRRKPPYRSHS CCCCCCCCCCCCCCC	39.72	-
446	Ubiquitination	MRRKPPYRSHSLSPS CCCCCCCCCCCCCCC	33.40	-
446	Ubiquitination	MRRKPPYRSHSLSPS CCCCCCCCCCCCCCC	33.40	30230243
447	Phosphorylation	RRKPPYRSHSLSPSP CCCCCCCCCCCCCCC	16.16	28176443
449	Phosphorylation	KPPYRSHSLSPSPVN CCCCCCCCCCCCCCC	31.61	19664994
451	Phosphorylation	PYRSHSLSPSPVNKH CCCCCCCCCCCCCHH	26.75	25159151
453	Phosphorylation	RSHSLSPSPVNKHKQ CCCCCCCCCCCHHHH	37.80	19664994
466	Ubiquitination	KQFHLERKRQRKPRE HHHHHHHHHCCCCCC	43.43	-
479	Ubiquitination	RETDVRQFQAQAFTE CCCCHHHHHHHHHHH	4.56	-
479	Ubiquitination	RETDVRQFQAQAFTE CCCCHHHHHHHHHHH	4.56	29967540
492	Ubiquitination	TEAFERELRRHKVQE HHHHHHHHHHHHHHH	7.95	22817900
496	Ubiquitination	ERELRRHKVQENIGP HHHHHHHHHHHHCCC	43.75	29967540
504	Ubiquitination	VQENIGPLRIHEKEE HHHHCCCCCCCCCHH	7.28	-
516	Ubiquitination	KEEETEKIYRGEAVR CHHHHHHHHCCCHHH	2.00	-
524	Ubiquitination	YRGEAVRKGTPECSQ HCCCHHHCCCCCCCC	61.61	29967540
526	Phosphorylation	GEAVRKGTPECSQPW CCHHHCCCCCCCCCC	20.96	28450419
530	Ubiquitination	RKGTPECSQPWKIYS HCCCCCCCCCCEEEE	37.30	-
530	Phosphorylation	RKGTPECSQPWKIYS HCCCCCCCCCCEEEE	37.30	27794612
530	Ubiquitination	RKGTPECSQPWKIYS HCCCCCCCCCCEEEE	37.30	29967540
534	Ubiquitination	PECSQPWKIYSRKTT CCCCCCCEEEECCCC	38.15	29967540
536	Phosphorylation	CSQPWKIYSRKTTTQ CCCCCEEEECCCCHH	9.94	23403867
537	Phosphorylation	SQPWKIYSRKTTTQS CCCCEEEECCCCHHH	30.67	24719451
540	Ubiquitination	WKIYSRKTTTQSLRG CEEEECCCCHHHHCC	33.68	-
540	Phosphorylation	WKIYSRKTTTQSLRG CEEEECCCCHHHHCC	33.68	23403867
540	Ubiquitination	WKIYSRKTTTQSLRG CEEEECCCCHHHHCC	33.68	22817900
541	Phosphorylation	KIYSRKTTTQSLRGG EEEECCCCHHHHCCC	26.35	18785766
542	Phosphorylation	IYSRKTTTQSLRGGL EEECCCCHHHHCCCC	22.76	18785766
543	Ubiquitination	YSRKTTTQSLRGGLP EECCCCHHHHCCCCC	38.07	22817900
544	Phosphorylation	SRKTTTQSLRGGLPK ECCCCHHHHCCCCCC	20.24	23403867
547	Ubiquitination	TTTQSLRGGLPKPNK CCHHHHCCCCCCCCC	47.48	22817900
561	Phosphorylation	KAVPMKVSEHSLLPL CCCCCCCCCCCHHHH	24.87	27251275
577	Phosphorylation	LEQFPFLYVSGPTLS HHHCCEEEECCHHHH	7.92	27251275
579	Phosphorylation	QFPFLYVSGPTLSKM HCCEEEECCHHHHHH	26.04	27251275
582	Phosphorylation	FLYVSGPTLSKMWKQ EEEECCHHHHHHHHH	47.38	27251275
584	Phosphorylation	YVSGPTLSKMWKQQI EECCHHHHHHHHHHH	23.96	27251275
588	Ubiquitination	PTLSKMWKQQIAQVE HHHHHHHHHHHHHHH	28.91	29967540
591	Ubiquitination	SKMWKQQIAQVEQLK HHHHHHHHHHHHHHH	2.41	-
591	Ubiquitination	SKMWKQQIAQVEQLK HHHHHHHHHHHHHHH	2.41	22817900
595	Ubiquitination	KQQIAQVEQLKKEAC HHHHHHHHHHHHHHH	37.81	22817900
598	Ubiquitination	IAQVEQLKKEACREN HHHHHHHHHHHHHHH	48.54	21906983
599	Ubiquitination	AQVEQLKKEACRENR HHHHHHHHHHHHHHH	60.17	22817900
603	Ubiquitination	QLKKEACRENRSKKK HHHHHHHHHHHHHHH	51.80	29967540
610	Ubiquitination	RENRSKKKLQDEIEE HHHHHHHHHHHHHHH	55.93	30230243
630	Ubiquitination	DLLTTLVKKEYEHNK HHHHHHHHHHHHHHH	42.89	-
643	Ubiquitination	NKRLQDFKDCIRRQR HHHHHHHHHHHHHHH	61.04	29967540
653	Ubiquitination	IRRQRLTQSKIKENR HHHHHHHHHHHHHHH	47.52	-
653	Ubiquitination	IRRQRLTQSKIKENR HHHHHHHHHHHHHHH	47.52	22505724
668	Ubiquitination	QQIVRARKYYDDYRV HHHHHHHHHHHHHHH	47.37	-
669	Phosphorylation	QIVRARKYYDDYRVQ HHHHHHHHHHHHHHH	13.43	20860994
670	Phosphorylation	IVRARKYYDDYRVQL HHHHHHHHHHHHHHH	12.84	20860994
673	Phosphorylation	ARKYYDDYRVQLCAK HHHHHHHHHHHHHHH	15.13	18083107
680	Ubiquitination	YRVQLCAKMMRMRTR HHHHHHHHHHHCCCH	32.03	-
686	Phosphorylation	AKMMRMRTREEMIFK HHHHHCCCHHHHHHH	32.84	27794612
694	Ubiquitination	REEMIFKKLFEEGLN HHHHHHHHHHHHCCC	47.89	29967540
704	Ubiquitination	EEGLNIQKQRLRDLR HHCCCHHHHHHHHHH	33.32	21906983
735	Phosphorylation	ELDSMENYYKDQFSL HHHHHHHHHHHHHHH	9.89	-
736	Phosphorylation	LDSMENYYKDQFSLL HHHHHHHHHHHHHHH	21.48	-
755	Ubiquitination	SQEHQELKAREKSQA HHHHHHHHHHHHHHH	44.65	21906983
759	Ubiquitination	QELKAREKSQAQTLH HHHHHHHHHHHHHHH	42.17	22817900
764	Phosphorylation	REKSQAQTLHKVKRE HHHHHHHHHHHHHHH	33.57	23403867
767	Ubiquitination	SQAQTLHKVKRELRS HHHHHHHHHHHHHHH	53.19	29967540
812	Phosphorylation	RSRLQLASFQYSKSP HHHHHHHHCCCCCCC	22.83	28555341
816	Phosphorylation	QLASFQYSKSPSL-- HHHHCCCCCCCCC--	18.84	22777824
817	Ubiquitination	LASFQYSKSPSL--- HHHCCCCCCCCC---	62.54	22505724
818	Phosphorylation	ASFQYSKSPSL---- HHCCCCCCCCC----	17.49	28450419
820	Phosphorylation	FQYSKSPSL------ CCCCCCCCC------	54.52	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CEP95_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CEP95_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CEP95_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FAM9B_HUMAN	FAM9B	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CEP95_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449; SER-451 ANDSER-453, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419 AND SER-422, ANDMASS SPECTROMETRY.	17525332 [Abstract]