CEP89_HUMAN - dbPTM
CEP89_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CEP89_HUMAN
UniProt AC Q96ST8
Protein Name Centrosomal protein of 89 kDa
Gene Name CEP89
Organism Homo sapiens (Human).
Sequence Length 783
Subcellular Localization Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Localizes
Protein Description Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity..
Protein Sequence MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATTLTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFETLDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHAPTC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationPKAAVPRTPPPRSPN
CHHCCCCCCCCCCCC		33.7923403867
40PhosphorylationPRTPPPRSPNPSPER
CCCCCCCCCCCCCCC		34.5024670416
44PhosphorylationPPRSPNPSPERPRSA
CCCCCCCCCCCCHHH		46.1424670416
50PhosphorylationPSPERPRSALAAAIL
CCCCCCHHHHHHHHH		30.2529255136
59PhosphorylationLAAAILATTLTGRTV
HHHHHHHHHHCCCEE		20.9222210691
60PhosphorylationAAAILATTLTGRTVA
HHHHHHHHHCCCEEC		19.4022210691
62PhosphorylationAILATTLTGRTVAIP
HHHHHHHCCCEECCC		23.6422210691
75PhosphorylationIPQPRQRSRSESDVS
CCCCCCCCCCHHHCC		31.6420873877
77PhosphorylationQPRQRSRSESDVSSV
CCCCCCCCHHHCCCH		42.5720873877
79PhosphorylationRQRSRSESDVSSVEQ
CCCCCCHHHCCCHHC		44.5530576142
82PhosphorylationSRSESDVSSVEQDSF
CCCHHHCCCHHCCCC		33.3928122231
83PhosphorylationRSESDVSSVEQDSFI
CCHHHCCCHHCCCCC		29.5330576142
88PhosphorylationVSSVEQDSFIEPYAT
CCCHHCCCCCCCCCC		28.0230576142
93PhosphorylationQDSFIEPYATTSQLR
CCCCCCCCCCCCCCC		12.0927642862
95PhosphorylationSFIEPYATTSQLRPR
CCCCCCCCCCCCCCC		22.5730576142
96PhosphorylationFIEPYATTSQLRPRP
CCCCCCCCCCCCCCC		13.3030576142
97PhosphorylationIEPYATTSQLRPRPN
CCCCCCCCCCCCCCC		23.9030576142
113PhosphorylationQSEMGRRSSLPSFET
HCCCCCCCCCCCCCC		34.5630266825
114PhosphorylationSEMGRRSSLPSFETL
CCCCCCCCCCCCCCC		42.3530266825
117PhosphorylationGRRSSLPSFETLDYG
CCCCCCCCCCCCCCC		40.7930266825
120PhosphorylationSSLPSFETLDYGDEE
CCCCCCCCCCCCCHH		23.9530266825
123PhosphorylationPSFETLDYGDEEDIE
CCCCCCCCCCHHHHH		29.5928450419
144PhosphorylationGKELGDVSAREDRGG
CCCCCCCCCCCCCCC		26.7521815630
153PhosphorylationREDRGGHSDDLYAVP
CCCCCCCCCCCCCCC		35.7730108239
156PhosphorylationRGGHSDDLYAVPHRN
CCCCCCCCCCCCCCC		3.3817016520
157PhosphorylationGGHSDDLYAVPHRNQ
CCCCCCCCCCCCCCC		16.7327273156
173PhosphorylationPLLHEVNSEDDENIS
CCEEECCCCCCCCCC		47.8025850435
180PhosphorylationSEDDENISHQDGFPG
CCCCCCCCCCCCCCC		27.0325850435
188PhosphorylationHQDGFPGSPPAPQRT
CCCCCCCCCCCCCCC		28.1328985074
221PhosphorylationLCEKPPPSPDITGRA
CCCCCCCCCCCCHHH		40.7630266825
225PhosphorylationPPPSPDITGRARQRY
CCCCCCCCHHHHHHH		28.1723663014
232PhosphorylationTGRARQRYTEITREK
CHHHHHHHHHHHHHH		10.6118083107
239UbiquitinationYTEITREKFEALKEE
HHHHHHHHHHHHHHH		45.2629967540
263PhosphorylationSLTLELNTMKQAMKE
HHHHHHHHHHHHHHH		38.0726503514
292PhosphorylationLKEAEKASSQEVAAP
HHHHHHHHHHHCHHH		43.5528348404
293PhosphorylationKEAEKASSQEVAAPE
HHHHHHHHHHCHHHH		34.9128348404
303PhosphorylationVAAPELLYLRKQAQE
CHHHHHHHHHHHHHH		19.6528152594
306UbiquitinationPELLYLRKQAQELVD
HHHHHHHHHHHHHHH		47.6029967540
334PhosphorylationVELSRYQTKFRHLSK
HHHHHHHHHHHCCCC		24.1824719451
340PhosphorylationQTKFRHLSKEESLNI
HHHHHCCCCCHHCCC		31.7120873877
341UbiquitinationTKFRHLSKEESLNIE
HHHHCCCCCHHCCCC		72.3829967540
344PhosphorylationRHLSKEESLNIEGLP
HCCCCCHHCCCCCCC		28.0120873877
352PhosphorylationLNIEGLPSKGPIPPW
CCCCCCCCCCCCCCH		56.1124719451
353UbiquitinationNIEGLPSKGPIPPWL
CCCCCCCCCCCCCHH		67.7629967540
386PhosphorylationEKDELNATLKEEMRM
HHHHHHHHHHHHHHH		36.9728509920
414UbiquitinationELHQELNKSSAVTSE
HHHHHHHHCCCCCHH		59.4129967540
415PhosphorylationLHQELNKSSAVTSEE
HHHHHHHCCCCCHHH		23.5822210691
416PhosphorylationHQELNKSSAVTSEEW
HHHHHHCCCCCHHHH		28.5022210691
419PhosphorylationLNKSSAVTSEEWRQL
HHHCCCCCHHHHHHH		30.0922210691
420PhosphorylationNKSSAVTSEEWRQLQ
HHCCCCCHHHHHHHH		27.2422210691
431UbiquitinationRQLQTQAKLVLEENK
HHHHHHHHHHHHHHH		29.3429967540
435 (in isoform 2)Ubiquitination-52.6321890473
451UbiquitinationLEIQQRKAKDSHQER
HHHHHHHCCHHHHHH		24.0722817900
452UbiquitinationEIQQRKAKDSHQERL
HHHHHHCCHHHHHHH		63.90-
453 (in isoform 2)Ubiquitination-57.1021890473
453UbiquitinationIQQRKAKDSHQERLQ
HHHHHCCHHHHHHHH		57.1021890473
464UbiquitinationERLQEVSKLTKQLML
HHHHHHHHHHHHHHH		66.4129967540
521UbiquitinationKSIVNELKSQLQKEE
HHHHHHHHHHHHHHH		29.9429967540
541UbiquitinationEMEELMEKLTVLQAQ
HHHHHHHHHHHHHHH		35.1829967540
550UbiquitinationTVLQAQKKSLLLEKN
HHHHHHHHHHHHHHC		33.9729967540
560PhosphorylationLLEKNSLTEQNKALE
HHHHCCHHHHHHHHH		35.03-
564UbiquitinationNSLTEQNKALEAELE
CCHHHHHHHHHHHHH		54.7829967540
627UbiquitinationDSLMCLAKCLESEKD
HHHHHHHHHHHHCCC		26.8032015554
642UbiquitinationGVLNKVIKSNIRLGK
CHHHHHHHHCCCCCC		40.2029967540
643PhosphorylationVLNKVIKSNIRLGKL
HHHHHHHHCCCCCCH		26.77-
664UbiquitinationYKKQAALKLGDISHR
CHHHHHHHHHHHHHH		45.7729967540
674UbiquitinationDISHRLLEQQEDFAG
HHHHHHHHHHHHHCC		55.6022817900
676UbiquitinationSHRLLEQQEDFAGKT
HHHHHHHHHHHCCHH		42.7421890473
682UbiquitinationQQEDFAGKTAQYRQE
HHHHHCCHHHHHHHH		36.9421906983
682 (in isoform 1)Ubiquitination-36.9421890473
698UbiquitinationRHLHQVLKDKQEVLD
HHHHHHHHHHHHHHH		65.1122817900
700UbiquitinationLHQVLKDKQEVLDQA
HHHHHHHHHHHHHHH		46.9321890473
700UbiquitinationLHQVLKDKQEVLDQA
HHHHHHHHHHHHHHH		46.9322817900
739PhosphorylationIRELLQDTLTRTGVQ
HHHHHHHHHHHHCCC		19.6427251275
743PhosphorylationLQDTLTRTGVQDNPR
HHHHHHHHCCCCCCC		36.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CEP89_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CEP89_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CEP89_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABLM1_HUMANABLIM1physical
26638075
ANR26_HUMANANKRD26physical
26638075
ANXA1_HUMANANXA1physical
26638075
ATG2B_HUMANATG2Bphysical
26638075
CP131_HUMANCEP131physical
26638075
CC014_HUMANC3orf14physical
26638075
C2D1A_HUMANCC2D1Aphysical
26638075
CC138_HUMANCCDC138physical
26638075
CCD14_HUMANCCDC14physical
26638075
CCD66_HUMANCCDC66physical
26638075
CCD77_HUMANCCDC77physical
26638075
CC85C_HUMANCCDC85Cphysical
26638075
CE170_HUMANCEP170physical
26638075
CEP55_HUMANCEP55physical
26638075
CRK_HUMANCRKphysical
26638075
CSPP1_HUMANCSPP1physical
26638075
DHX35_HUMANDHX35physical
26638075
DLG5_HUMANDLG5physical
26638075
FR1OP_HUMANFGFR1OPphysical
26638075
FLII_HUMANFLIIphysical
26638075
GPTC1_HUMANGPATCH1physical
26638075
HAUS2_HUMANHAUS2physical
26638075
HAUS3_HUMANHAUS3physical
26638075
HAUS4_HUMANHAUS4physical
26638075
HAUS5_HUMANHAUS5physical
26638075
HAUS6_HUMANHAUS6physical
26638075
HAUS7_HUMANHAUS7physical
26638075
HAUS8_HUMANHAUS8physical
26638075
MOONR_HUMANKIAA0753physical
26638075
KIF7_HUMANKIF7physical
26638075
LUZP1_HUMANLUZP1physical
26638075
M21D2_HUMANMB21D2physical
26638075
MED4_HUMANMED4physical
26638075
MPP9_HUMANMPHOSPH9physical
26638075
NCS1_HUMANNCS1physical
26638075
NDK7_HUMANNME7physical
26638075
NMT1_HUMANNMT1physical
26638075
OFD1_HUMANOFD1physical
26638075
PCM1_HUMANPCM1physical
26638075
PIBF1_HUMANPIBF1physical
26638075
PKHG1_HUMANPLEKHG1physical
26638075
RN219_HUMANRNF219physical
26638075
SMAG2_HUMANSAMD4Bphysical
26638075
SIR2_HUMANSIRT2physical
26638075
SRBD1_HUMANSRBD1physical
26638075
ADIP_HUMANSSX2IPphysical
26638075
TCHP_HUMANTCHPphysical
26638075
ASPP2_HUMANTP53BP2physical
26638075
TXLNG_HUMANTXLNGphysical
26638075
UN45A_HUMANUNC45Aphysical
26638075
WDR83_HUMANWDR83physical
26638075
WRP73_HUMANWRAP73physical
26638075
XRN1_HUMANXRN1physical
26638075
1433G_HUMANYWHAGphysical
26638075
1433F_HUMANYWHAHphysical
26638075
PUR8_HUMANADSLphysical
26638075
C2CD3_HUMANC2CD3physical
26638075
CE164_HUMANCEP164physical
26638075
CE350_HUMANCEP350physical
26638075
CEP72_HUMANCEP72physical
26638075
RB6I2_HUMANERC1physical
26638075
K1671_HUMANKIAA1671physical
26638075
KIF14_HUMANKIF14physical
26638075
MA7D3_HUMANMAP7D3physical
26638075
MARK2_HUMANMARK2physical
26638075
MOB2_HUMANMOB2physical
26638075
PHOCN_HUMANMOB4physical
26638075
NAV1_HUMANNAV1physical
26638075
NPHP4_HUMANNPHP4physical
26638075
SDCG3_HUMANSDCCAG3physical
26638075
CMC1_HUMANSLC25A12physical
26638075
TBD2B_HUMANTBC1D2Bphysical
26638075
TRI37_HUMANTRIM37physical
26638075
TTK_HUMANTTKphysical
26638075
TXLNA_HUMANTXLNAphysical
26638075
WIPI4_HUMANWDR45physical
26638075
TBC31_HUMANTBC1D31physical
26638075
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CEP89_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.

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