NCS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCS1_HUMAN
• UniProt AC: P62166
• Protein Name: Neuronal calcium sensor 1
• Gene Name: NCS1
• Organism: Homo sapiens (Human).
• Sequence Length: 190
• Subcellular Localization: Golgi apparatus . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cytoplasm, perinuclear region . Cytoplasm . Cell membrane ; Peripheral membrane protein. Membrane ; Lipid-anchor . Associated with Golgi stacks. Post-synapti
• Protein Description: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity)..
• Protein Sequence: MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGKSNSKLK ------CCCCCCCCC	41.94	-
2	Myristoylation	------MGKSNSKLK ------CCCCCCCCC	41.94	25255805
25	Ubiquitination	RKTYFTEKEVQQWYK HHCCCCHHHHHHHHH	61.19	21890473
50	Ubiquitination	LDAAGFQKIYKQFFP CCHHHHHHHHHHHCC	45.82	-
53	Ubiquitination	AGFQKIYKQFFPFGD HHHHHHHHHHCCCCC	44.07	21890473
53	Sumoylation	AGFQKIYKQFFPFGD HHHHHHHHHHCCCCC	44.07	-
108	Phosphorylation	LRWAFKLYDLDNDGY HHHHHHHEECCCCCC	18.30	24719451
115	Phosphorylation	YDLDNDGYITRNEML EECCCCCCCCHHHHH	11.28	21082442
117	Phosphorylation	LDNDGYITRNEMLDI CCCCCCCCHHHHHHH	20.96	24719451
135	Phosphorylation	IYQMVGNTVELPEEE HHHHHCCCCCCCCCC	14.93	27732954
144	Phosphorylation	ELPEEENTPEKRVDR CCCCCCCCCHHHHHH	35.78	25159151
186	Phosphorylation	IVQALSLYDGLV--- HHHHHHHHCCCC---	12.46	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRPL1_HUMAN	IL1RAPL1	physical	12783849
DTX2_HUMAN	DTX2	physical	16189514
PI4KB_HUMAN	PI4KB	physical	14607934
DRD2_HUMAN	DRD2	physical	12351722
DRD3_HUMAN	DRD3	physical	12351722
PI4KB_HUMAN	PI4KB	physical	11526106
KDM3B_HUMAN	KDM3B	physical	22863883
KI21A_HUMAN	KIF21A	physical	22863883
NAF1_HUMAN	NAF1	physical	22863883
RSMB_HUMAN	SNRPB	physical	22863883
SRP68_HUMAN	SRP68	physical	22863883
DTX2_HUMAN	DTX2	physical	25416956
BSPRY_HUMAN	BSPRY	physical	28514442
ABHD6_HUMAN	ABHD6	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
UBP24_HUMAN	USP24	physical	28514442
KITH_HUMAN	TK1	physical	28514442
NMT1_HUMAN	NMT1	physical	28514442
CNOT3_HUMAN	CNOT3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.