dbPTM

UBP24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP24_HUMAN
UniProt AC	Q9UPU5
Protein Name	Ubiquitin carboxyl-terminal hydrolase 24
Gene Name	USP24
Organism	Homo sapiens (Human).
Sequence Length	2620
Subcellular Localization
Protein Description	Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation..
Protein Sequence	MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGGPSPGPGGGPRGDGGGDGGGGGPSRGGSTGGGGGFDPPPAYHEVVDAEKNDENGNCSGEGIEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELGGFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKDLKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTKLIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKSWETESDRVRQKLLSLIGRIGREARFETTSGKVLDVLWELAHLPTLPSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRPGEWSGLEKNKKDGFKSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDNIQIFTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMALVCNVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLVGQTMPTLLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESEEEQHMT -----CCCHHHHHHC	63.27	24043423
10	Phosphorylation	SEEEQHMTTLLCMGF CHHHHHHCHHHHHCC	16.50	24043423
11	Phosphorylation	EEEQHMTTLLCMGFS HHHHHHCHHHHHCCC	15.34	24043423
18	Phosphorylation	TLLCMGFSDPATIRK HHHHHCCCCHHHHHH	36.63	24043423
22	Phosphorylation	MGFSDPATIRKALRL HCCCCHHHHHHHHHH	27.06	24043423
25	Ubiquitination	SDPATIRKALRLAKN CCHHHHHHHHHHHHC	48.17	23503661
31	Ubiquitination	RKALRLAKNDINEAV HHHHHHHHCCHHHHH	60.80	21963094
42	Phosphorylation	NEAVALLTNERPGLD HHHHHHHHCCCCCCC	35.56	27080861
50	Phosphorylation	NERPGLDYGGYEPMD CCCCCCCCCCCCCCC	19.93	24719451
53	Phosphorylation	PGLDYGGYEPMDSGG CCCCCCCCCCCCCCC	16.70	27251275
53	Ubiquitination	PGLDYGGYEPMDSGG CCCCCCCCCCCCCCC	16.70	23000965
58	Phosphorylation	GGYEPMDSGGGPSPG CCCCCCCCCCCCCCC	32.84	18669648
58	Ubiquitination	GGYEPMDSGGGPSPG CCCCCCCCCCCCCCC	32.84	23000965
61	Ubiquitination	EPMDSGGGPSPGPGG CCCCCCCCCCCCCCC	24.04	22053931
63	Phosphorylation	MDSGGGPSPGPGGGP CCCCCCCCCCCCCCC	45.85	25159151
84	Phosphorylation	DGGGGGPSRGGSTGG CCCCCCCCCCCCCCC	47.00	25159151
85	Methylation	GGGGGPSRGGSTGGG CCCCCCCCCCCCCCC	57.54	115919601
88	Phosphorylation	GGPSRGGSTGGGGGF CCCCCCCCCCCCCCC	27.06	25159151
89	Phosphorylation	GPSRGGSTGGGGGFD CCCCCCCCCCCCCCC	43.02	23663014
100	Ubiquitination	GGFDPPPAYHEVVDA CCCCCCCCCCEEECH	24.88	21963094
101	Phosphorylation	GFDPPPAYHEVVDAE CCCCCCCCCEEECHH	12.32	29396449
117	Phosphorylation	NDENGNCSGEGIEFP CCCCCCCCCCCEECC	43.83	24850871
125	Phosphorylation	GEGIEFPTTNLYELE CCCEECCCCCHHHHH	33.37	28102081
126	Phosphorylation	EGIEFPTTNLYELES CCEECCCCCHHHHHH	24.38	28102081
145	Ubiquitination	DHWSIPYKREESLGK CCCCCCCCCHHHHHH	48.23	29967540
152	Ubiquitination	KREESLGKCLLASTY CCHHHHHHHHHHHHH	27.31	-
157	Phosphorylation	LGKCLLASTYLARLG HHHHHHHHHHHHHCC	19.97	24505115
179	Ubiquitination	CRRFMDRCMPEAFKK HHHHHHHHCHHHHHH	4.68	24816145
198	Phosphorylation	SAVHKWGTEIHEGIY HHHHHHCCHHHHHHH	30.56	20068231
205	Phosphorylation	TEIHEGIYNMLMLLI CHHHHHHHHHHHHHH	12.84	20068231
246	Ubiquitination	DNEYHFKNRMKVSQR CCCCCCCCCCCCCCC	48.62	21963094
249	Ubiquitination	YHFKNRMKVSQRNWA CCCCCCCCCCCCCHH	35.18	22817900
251	Phosphorylation	FKNRMKVSQRNWAEV CCCCCCCCCCCHHHH	20.22	-
274	Ubiquitination	VSPVSTFQKEPHGWV ECCCCCCCCCCCCEE	49.65	21963094
275	Ubiquitination	SPVSTFQKEPHGWVV CCCCCCCCCCCCEEE	69.86	21963094
287	Ubiquitination	WVVDLVNKFGELGGF EEEECHHHHHHHCHH	47.47	-
300	Phosphorylation	GFAAIQAKLHSEDIE HHHHHHHHCCCCCCC	30.29	15302935
353	Ubiquitination	RSVEEKDLKDKRLVS HCCCCCCCCCCCCCC	13.16	24816145
354	Ubiquitination	SVEEKDLKDKRLVSI CCCCCCCCCCCCCCH	71.92	24816145
369	Ubiquitination	PELLSAVKLLCMRFQ HHHHHHHHHHHHHHC	35.14	30230243
381	Phosphorylation	RFQPDLVTIVDDLRL HHCCCCEEHHHHHHH	23.68	-
397	Phosphorylation	ILLRMLKSPHFSAKM HHHHHHCCCCHHHHH	21.46	21955146
403	Ubiquitination	KSPHFSAKMNSLKEV CCCCHHHHHCCHHHH	37.10	29967540
420	Phosphorylation	LIEDSTLSKSVKNAI HHHCCCCCHHHHHHH	23.99	28509920
420	Ubiquitination	LIEDSTLSKSVKNAI HHHCCCCCHHHHHHH	23.99	21963094
421	Ubiquitination	IEDSTLSKSVKNAID HHCCCCCHHHHHHHC	63.48	21963094
422	Phosphorylation	EDSTLSKSVKNAIDT HCCCCCHHHHHHHCH	34.64	28509920
423	Ubiquitination	DSTLSKSVKNAIDTD CCCCCHHHHHHHCHH	6.78	22817900
424	Ubiquitination	STLSKSVKNAIDTDR CCCCHHHHHHHCHHH	47.99	22817900
473	Ubiquitination	LGSKLSLDELTKIWK HCCCCCHHHHHHHEE	45.54	23000965
478	Ubiquitination	SLDELTKIWKIQSGQ CHHHHHHHEEECCCC	3.69	23000965
481	Ubiquitination	ELTKIWKIQSGQSST HHHHHEEECCCCCCC	2.07	22053931
493	Ubiquitination	SSTVIENIHTIIAAA CCCHHHHHHHHHHHH	1.65	23000965
498	Ubiquitination	ENIHTIIAAAAVKFN HHHHHHHHHHHHHCC	6.28	23000965
501	Ubiquitination	HTIIAAAAVKFNSDQ HHHHHHHHHHCCHHH	10.58	22053931
593	Phosphorylation	VKEAIKRSYIIKCIE HHHHHHHHHHHHHHH	18.71	24719451
594	Phosphorylation	KEAIKRSYIIKCIED HHHHHHHHHHHHHHH	15.65	24719451
603	Ubiquitination	IKCIEDIKRPGEWSG HHHHHHCCCCCCCCC	65.93	29967540
615	Ubiquitination	WSGLEKNKKDGFKSS CCCCCCCCCCCCCHH	64.41	29967540
620	Ubiquitination	KNKKDGFKSSQLNNP CCCCCCCCHHHCCCC	55.52	32015554
621	Phosphorylation	NKKDGFKSSQLNNPQ CCCCCCCHHHCCCCC	22.51	28857561
622	Phosphorylation	KKDGFKSSQLNNPQF CCCCCCHHHCCCCCE	39.00	28857561
645	Phosphorylation	QLHEITRSFIKQTYQ HHHHHHHHHHHHHHH	23.75	24719451
648	Ubiquitination	EITRSFIKQTYQKQD HHHHHHHHHHHHHCC	34.28	23000965
653	Ubiquitination	FIKQTYQKQDKSIIQ HHHHHHHHCCHHHHH	50.48	23000965
656	Ubiquitination	QTYQKQDKSIIQDLK HHHHHCCHHHHHHHH	40.85	22053931
657	Phosphorylation	TYQKQDKSIIQDLKK HHHHCCHHHHHHHHH	32.96	-
663	Ubiquitination	KSIIQDLKKNFEIVK HHHHHHHHHHCHHHH	54.69	29967540
664	Ubiquitination	SIIQDLKKNFEIVKL HHHHHHHHHCHHHHH	74.33	29967540
667	Ubiquitination	QDLKKNFEIVKLVTG HHHHHHCHHHHHHCC	57.15	23000965
668	Ubiquitination	DLKKNFEIVKLVTGS HHHHHCHHHHHHCCC	2.64	23000965
672	Ubiquitination	NFEIVKLVTGSLIAC HCHHHHHHCCCHHHH	4.76	23000965
673	Phosphorylation	FEIVKLVTGSLIACH CHHHHHHCCCHHHHH	31.33	-
673	Ubiquitination	FEIVKLVTGSLIACH CHHHHHHCCCHHHHH	31.33	23000965
675	Ubiquitination	IVKLVTGSLIACHRL HHHHHCCCHHHHHHH	13.77	22053931
676	Ubiquitination	VKLVTGSLIACHRLA HHHHCCCHHHHHHHH	2.81	22053931
693	Phosphorylation	VAGPGGLSGSTLVDG HHCCCCCCCCCEECC	33.69	21955146
695	Phosphorylation	GPGGLSGSTLVDGRY CCCCCCCCCEECCCC	18.39	21955146
696	Phosphorylation	PGGLSGSTLVDGRYT CCCCCCCCEECCCCC	34.03	21955146
702	Phosphorylation	STLVDGRYTYREYLE CCEECCCCCHHHHHH	17.41	21955146
703	Phosphorylation	TLVDGRYTYREYLEA CEECCCCCHHHHHHH	18.10	21955146
704	Phosphorylation	LVDGRYTYREYLEAH EECCCCCHHHHHHHH	7.78	21955146
707	Phosphorylation	GRYTYREYLEAHLKF CCCCHHHHHHHHHHH	10.80	21955146
761	Ubiquitination	EWFTKGQHDLESDVQ HHHHCCCCCCCHHHH	50.74	24816145
773	Ubiquitination	DVQQQLFKEKILKLE HHHHHHHHHHCHHHH	67.69	29967540
814	Phosphorylation	KRQGAQLYVEKLELI HHCCCHHHHHHHHHH	8.42	-
860	Ubiquitination	NLNPRLKKDSVSLHK CCCCCCCCCCHHHHH	60.88	29967540
862	Phosphorylation	NPRLKKDSVSLHKKF CCCCCCCCHHHHHHH	23.61	29083192
864	Phosphorylation	RLKKDSVSLHKKFIA CCCCCCHHHHHHHHH	28.80	29083192
866	Phosphorylation	KKDSVSLHKKFIADC CCCCHHHHHHHHHHH	24.61	17081983
870	Phosphorylation	VSLHKKFIADCYTRL HHHHHHHHHHHHHHH	4.31	17525332
881	Phosphorylation	YTRLEAASSALGGPT HHHHHHHHHHHCCCH	24.16	20071362
882	Phosphorylation	TRLEAASSALGGPTL HHHHHHHHHHCCCHH	23.84	20071362
888	Phosphorylation	SSALGGPTLTHAVTR HHHHCCCHHHHHHHH	47.79	20071362
894	Phosphorylation	PTLTHAVTRATKMLT CHHHHHHHHHHHHHH	18.50	20071362
901	Phosphorylation	TRATKMLTATAMPTV HHHHHHHHHCCCCCC	20.61	29396449
903	Phosphorylation	ATKMLTATAMPTVAT HHHHHHHCCCCCCHH	20.46	27080861
907	Phosphorylation	LTATAMPTVATSVQS HHHCCCCCCHHHCCC	15.08	29396449
910	Phosphorylation	TAMPTVATSVQSPYR CCCCCCHHHCCCCCC	25.70	25159151
911	Phosphorylation	AMPTVATSVQSPYRS CCCCCHHHCCCCCCC	14.39	25159151
914	Phosphorylation	TVATSVQSPYRSTKL CCHHHCCCCCCCCHH	23.03	27050516
916	Phosphorylation	ATSVQSPYRSTKLVI HHHCCCCCCCCHHHH	23.57	29396449
942	Phosphorylation	VITIEDFYSVPRTIL EEEHHHHHCCCCCCC	22.53	-
1017	Ubiquitination	LTVNKDQKLLHQLGF EECCCCHHHHHHCCC	64.25	29967540
1034	Phosphorylation	EQILTVKTSGSGTPS CCEEEEEECCCCCCC	33.70	23186163
1035	Phosphorylation	QILTVKTSGSGTPSG CEEEEEECCCCCCCC	25.83	23186163
1037	Phosphorylation	LTVKTSGSGTPSGSS EEEEECCCCCCCCCC	38.98	23186163
1039	Phosphorylation	VKTSGSGTPSGSSAD EEECCCCCCCCCCCC	18.91	21712546
1041	Phosphorylation	TSGSGTPSGSSADSS ECCCCCCCCCCCCCC	51.66	23186163
1043	Phosphorylation	GSGTPSGSSADSSTS CCCCCCCCCCCCCCC	27.04	18669648
1044	Phosphorylation	SGTPSGSSADSSTSS CCCCCCCCCCCCCCC	39.35	23186163
1050	Phosphorylation	SSADSSTSSSSSSSG CCCCCCCCCCCCCCC	30.12	15302935
1060	Phosphorylation	SSSSGVFSSSYAMEQ CCCCCCCCCCHHHHH	18.90	-
1063	Phosphorylation	SGVFSSSYAMEQEKS CCCCCCCHHHHHHCC	16.35	-
1128	Ubiquitination	LDSLGRKKTLLSESS HHHHCCHHHHHCCCC	42.94	29967540
1129	Phosphorylation	DSLGRKKTLLSESSS HHHCCHHHHHCCCCC	35.65	23927012
1132	Phosphorylation	GRKKTLLSESSSQSS CCHHHHHCCCCCCCC	38.25	23927012
1134	Phosphorylation	KKTLLSESSSQSSKS HHHHHCCCCCCCCCC	31.73	30278072
1135	Phosphorylation	KTLLSESSSQSSKSP HHHHCCCCCCCCCCC	28.48	23927012
1136	Phosphorylation	TLLSESSSQSSKSPS HHHCCCCCCCCCCCC	43.28	30278072
1138	Phosphorylation	LSESSSQSSKSPSLS HCCCCCCCCCCCCCC	41.50	30278072
1139	Phosphorylation	SESSSQSSKSPSLSS CCCCCCCCCCCCCCC	29.52	22167270
1140	Ubiquitination	ESSSQSSKSPSLSSK CCCCCCCCCCCCCCC	72.18	32015554
1141	Phosphorylation	SSSQSSKSPSLSSKQ CCCCCCCCCCCCCCH	22.97	22167270
1143	Phosphorylation	SQSSKSPSLSSKQQH CCCCCCCCCCCCHHC	48.23	22167270
1145	Phosphorylation	SSKSPSLSSKQQHQP CCCCCCCCCCHHCCC	39.57	30266825
1146	Phosphorylation	SKSPSLSSKQQHQPS CCCCCCCCCHHCCCC	39.51	30278072
1165	Ubiquitination	LESLFRSFAPGMSTF HHHHHHHHCCCCCHH	9.19	23000965
1169	Ubiquitination	FRSFAPGMSTFRVLY HHHHCCCCCHHHHHH	3.12	23000965
1181	Ubiquitination	VLYNLEVLSSKLMPT HHHCHHHHHCCCCCC	3.32	24816145
1184	Ubiquitination	NLEVLSSKLMPTADD CHHHHHCCCCCCCCH	45.49	-
1193	Phosphorylation	MPTADDDMARSCAKS CCCCCHHHHHHHHHH	4.25	15302935
1201	Ubiquitination	ARSCAKSFCENFLKA HHHHHHHHHHHHHHH	6.29	24816145
1270	Phosphorylation	DGIEALSSRPFRNVS HHHHHHHCCCCCCCC	44.84	28555341
1274	Phosphorylation	ALSSRPFRNVSRQTS HHHCCCCCCCCHHHH	45.37	15144186
1280	Phosphorylation	FRNVSRQTSRQMSLC CCCCCHHHHHHHHCC	25.43	-
1281	Phosphorylation	RNVSRQTSRQMSLCG CCCCHHHHHHHHCCC	16.51	-
1285	Phosphorylation	RQTSRQMSLCGTPEK HHHHHHHHCCCCCCC	16.51	23401153
1289	Phosphorylation	RQMSLCGTPEKSSYR HHHHCCCCCCCCCCC	27.55	25159151
1292	Ubiquitination	SLCGTPEKSSYRQLS HCCCCCCCCCCCCCC	46.00	-
1293	Phosphorylation	LCGTPEKSSYRQLSV CCCCCCCCCCCCCCC	30.82	23090842
1294	Phosphorylation	CGTPEKSSYRQLSVS CCCCCCCCCCCCCCC	35.09	23090842
1295	Phosphorylation	GTPEKSSYRQLSVSD CCCCCCCCCCCCCCC	14.96	30576142
1297	Phosphorylation	PEKSSYRQLSVSDRS CCCCCCCCCCCCCCC	29.83	16964243
1299	Phosphorylation	KSSYRQLSVSDRSSI CCCCCCCCCCCCCCC	15.96	23401153
1301	Phosphorylation	SYRQLSVSDRSSIRV CCCCCCCCCCCCCCH	24.75	26552605
1304	Phosphorylation	QLSVSDRSSIRVEEI CCCCCCCCCCCHHHH	34.80	23312004
1304	Ubiquitination	QLSVSDRSSIRVEEI CCCCCCCCCCCHHHH	34.80	24816145
1305	Phosphorylation	LSVSDRSSIRVEEII CCCCCCCCCCHHHHH	18.46	30576142
1321	Phosphorylation	AARVAIQTMEVSDFT HHHHHHEEECHHHCH	14.80	-
1329	Phosphorylation	MEVSDFTSTVACFMR ECHHHCHHHHHHHHH	22.37	-
1330	Phosphorylation	EVSDFTSTVACFMRL CHHHCHHHHHHHHHH	14.74	-
1351	Phosphorylation	GRLDLVGSSQPIKES CCCCCCCCCCCCCCC	20.51	25693802
1352	Phosphorylation	RLDLVGSSQPIKESN CCCCCCCCCCCCCCC	33.76	25693802
1356	Ubiquitination	VGSSQPIKESNSLCP CCCCCCCCCCCCCCC	62.87	33845483
1358	Phosphorylation	SSQPIKESNSLCPAG CCCCCCCCCCCCCHH	27.07	23403867
1360	Phosphorylation	QPIKESNSLCPAGIR CCCCCCCCCCCHHHH	40.40	23403867
1371	Phosphorylation	AGIRNRLSSSGSNCS HHHHHHHHCCCCCCC	21.15	23401153
1372	Phosphorylation	GIRNRLSSSGSNCSS HHHHHHHCCCCCCCC	43.22	27273156
1373	Phosphorylation	IRNRLSSSGSNCSSG HHHHHHCCCCCCCCC	42.75	27273156
1375	Phosphorylation	NRLSSSGSNCSSGSE HHHHCCCCCCCCCCC	36.29	28450419
1375	Ubiquitination	NRLSSSGSNCSSGSE HHHHCCCCCCCCCCC	36.29	24816145
1376	Ubiquitination	RLSSSGSNCSSGSEG HHHCCCCCCCCCCCC	32.96	24816145
1378	Phosphorylation	SSSGSNCSSGSEGEP HCCCCCCCCCCCCCC	41.82	28450419
1379	Phosphorylation	SSGSNCSSGSEGEPV CCCCCCCCCCCCCCE	48.84	30576142
1381	Phosphorylation	GSNCSSGSEGEPVAL CCCCCCCCCCCCEEE	44.36	28464451
1502	Ubiquitination	SIMRGVNQRLLSQCM HHHHHHHHHHHHHHH	34.68	21890473
1505	Ubiquitination	RGVNQRLLSQCMEYF HHHHHHHHHHHHHHH	3.46	22817900
1506	Ubiquitination	GVNQRLLSQCMEYFD HHHHHHHHHHHHHHH	26.40	22817900
1534	Ubiquitination	MEQLRISPATMLEDE HHHHCCCCCHHHCCE	29.40	24816145
1575	Phosphorylation	GHLRLIKTLLSLCGA HHHHHHHHHHHHCCC	26.41	-
1578	Phosphorylation	RLIKTLLSLCGAEKE HHHHHHHHHCCCCHH	25.40	-
1585	Ubiquitination	SLCGAEKEMLGSSLI HHCCCCHHHHCCCCH	31.01	23000965
1589	Ubiquitination	AEKEMLGSSLIKPLL CCHHHHCCCCHHHHH	20.29	23000965
1590	Phosphorylation	EKEMLGSSLIKPLLD CHHHHCCCCHHHHHH	32.11	24719451
1605	Ubiquitination	DFLFRASRIILNSHS HHHHHHHHHHHCCCC	20.98	23000965
1609	Ubiquitination	RASRIILNSHSPAGS HHHHHHHCCCCCCCC	27.54	23000965
1610	Phosphorylation	ASRIILNSHSPAGSA HHHHHHCCCCCCCCC	23.15	23401153
1612	Phosphorylation	RIILNSHSPAGSAAI HHHHCCCCCCCCCCC	19.10	23927012
1616	Phosphorylation	NSHSPAGSAAISQQD CCCCCCCCCCCCCCC	19.34	23927012
1620	Phosphorylation	PAGSAAISQQDFHPK CCCCCCCCCCCCCCC	19.64	17525332
1627	Ubiquitination	SQQDFHPKCSTANSR CCCCCCCCCCCHHHH	32.04	-
1724	Ubiquitination	LLSVDDDTDNPDDSV HCCCCCCCCCCCCCH	44.67	24816145
1744	Ubiquitination	SLFGHLMESKLQYYV HHHHHHHHHHHHHHC	51.59	24816145
1760	Ubiquitination	ENFWKIFKMWNKELY HHHHHHHHHHCCHHH	46.62	23000965
1764	Ubiquitination	KIFKMWNKELYVREQ HHHHHHCCHHHHCCH	33.32	23000965
1779	Ubiquitination	QDAYEFFTSLIDQMD HHHHHHHHHHHHHHH	28.13	23000965
1780	Ubiquitination	DAYEFFTSLIDQMDE HHHHHHHHHHHHHHH	20.40	23000965
1783	Ubiquitination	EFFTSLIDQMDEYLK HHHHHHHHHHHHHHH	42.94	23000965
1784	Ubiquitination	FFTSLIDQMDEYLKK HHHHHHHHHHHHHHH	33.94	23000965
1809	Phosphorylation	FQGIYSDQKICKDCP CCHHCCCCHHHCCCC	30.95	15302935
1854	Phosphorylation	RGEVLEGSNAYYCEK CCCCCCCCCCEECCC	14.65	23401153
1857	Phosphorylation	VLEGSNAYYCEKCKE CCCCCCCEECCCCCC	16.95	29978859
1858	Phosphorylation	LEGSNAYYCEKCKEK CCCCCCEECCCCCCC	7.54	23312004
1861	Ubiquitination	SNAYYCEKCKEKRIT CCCEECCCCCCCCEE	47.23	33845483
1899	Ubiquitination	WESGRSIKYDEQIRF CCCCCCCCCCCCCCC	48.14	24816145
1918	Ubiquitination	NMEPYTVSGMARQDS CCCCEEECEEECCCC	18.30	24816145
1919	Ubiquitination	MEPYTVSGMARQDSS CCCEEECEEECCCCC	14.94	24816145
1922	Ubiquitination	YTVSGMARQDSSSEV EEECEEECCCCCCCC	31.76	21890473
1925	Phosphorylation	SGMARQDSSSEVGEN CEEECCCCCCCCCCC	27.68	28102081
1925	Ubiquitination	SGMARQDSSSEVGEN CEEECCCCCCCCCCC	27.68	22817900
1926	Phosphorylation	GMARQDSSSEVGENG EEECCCCCCCCCCCC	38.52	28102081
1926	Ubiquitination	GMARQDSSSEVGENG EEECCCCCCCCCCCC	38.52	22817900
1927	Phosphorylation	MARQDSSSEVGENGR EECCCCCCCCCCCCC	40.01	28102081
1935	Phosphorylation	EVGENGRSVDQGGGG CCCCCCCCCCCCCCC	31.29	25159151
1942	Ubiquitination	SVDQGGGGSPRKKVA CCCCCCCCCCCCCEE	37.44	21890473
1943	Phosphorylation	VDQGGGGSPRKKVAL CCCCCCCCCCCCEEE	25.47	30266825
1945	Ubiquitination	QGGGGSPRKKVALTE CCCCCCCCCCEEECC	53.80	22817900
1946	Ubiquitination	GGGGSPRKKVALTEN CCCCCCCCCEEECCC	55.79	22817900
1954	Ubiquitination	KVALTENYELVGVIV CEEECCCEEEEEEEE	12.38	24816145
1959	Ubiquitination	ENYELVGVIVHSGQA CCEEEEEEEEECCCC	3.01	23000965
1973	Phosphorylation	AHAGHYYSFIKDRRG CCCCHHHHEEECCCC	17.21	24719451
1974	Ubiquitination	HAGHYYSFIKDRRGC CCCHHHHEEECCCCC	4.68	24816145
2018	Phosphorylation	GEYRPKVYDQTNPYT CCCCCCCCCCCCCCH	14.41	21945579
2021	Phosphorylation	RPKVYDQTNPYTDVR CCCCCCCCCCCHHHH	34.95	21945579
2024	Phosphorylation	VYDQTNPYTDVRRRY CCCCCCCCHHHHHHH	20.03	21945579
2025	Phosphorylation	YDQTNPYTDVRRRYW CCCCCCCHHHHHHHH	29.31	21945579
2031	Phosphorylation	YTDVRRRYWNAYMLF CHHHHHHHHHHHHHH	10.95	26552605
2035	Phosphorylation	RRRYWNAYMLFYQRV HHHHHHHHHHHHHHH	7.37	26552605
2039	Phosphorylation	WNAYMLFYQRVSDQN HHHHHHHHHHHCCCC	7.46	26552605
2043	Phosphorylation	MLFYQRVSDQNSPVL HHHHHHHCCCCCCCC	35.35	30266825
2047	Phosphorylation	QRVSDQNSPVLPKKS HHHCCCCCCCCCCCC	15.68	19664994
2054	Phosphorylation	SPVLPKKSRVSVVRQ CCCCCCCCCEEEEHH	44.00	26699800
2057	Phosphorylation	LPKKSRVSVVRQEAE CCCCCCEEEEHHHHH	17.49	26074081
2067	Phosphorylation	RQEAEDLSLSAPSSP HHHHHHCCCCCCCCC	32.38	30266825
2069	Phosphorylation	EAEDLSLSAPSSPEI HHHHCCCCCCCCCCC	34.46	30266825
2072	Phosphorylation	DLSLSAPSSPEISPQ HCCCCCCCCCCCCCC	59.24	30266825
2073	Phosphorylation	LSLSAPSSPEISPQS CCCCCCCCCCCCCCC	26.03	30266825
2077	Phosphorylation	APSSPEISPQSSPRP CCCCCCCCCCCCCCC	18.41	23401153
2080	Phosphorylation	SPEISPQSSPRPHRP CCCCCCCCCCCCCCC	45.77	23401153
2081	Phosphorylation	PEISPQSSPRPHRPN CCCCCCCCCCCCCCC	21.49	30266825
2093	Phosphorylation	RPNNDRLSILTKLVK CCCCCHHHHHHHHHH	19.22	24719451
2096	Phosphorylation	NDRLSILTKLVKKGE CCHHHHHHHHHHHCC	22.21	26074081
2097	Ubiquitination	DRLSILTKLVKKGEK CHHHHHHHHHHHCCC	48.08	22817900
2100	Ubiquitination	SILTKLVKKGEKKGL HHHHHHHHHCCCCCC	66.55	22817900
2101	Ubiquitination	ILTKLVKKGEKKGLF HHHHHHHHCCCCCCC	65.90	22817900
2105	Ubiquitination	LVKKGEKKGLFVEKM HHHHCCCCCCCCCCC	57.45	29967540
2116	Ubiquitination	VEKMPARIYQMVRDE CCCCCHHHHHHHHHC	2.81	21890473
2117	Phosphorylation	EKMPARIYQMVRDEN CCCCHHHHHHHHHCC	5.75	25278378
2117	Ubiquitination	EKMPARIYQMVRDEN CCCCHHHHHHHHHCC	5.75	21890473
2119	Ubiquitination	MPARIYQMVRDENLK CCHHHHHHHHHCCCC	1.18	22817900
2120	Ubiquitination	PARIYQMVRDENLKF CHHHHHHHHHCCCCC	4.04	22817900
2121	Ubiquitination	ARIYQMVRDENLKFM HHHHHHHHHCCCCCC	39.93	22817900
2129	Ubiquitination	DENLKFMKNRDVYSS HCCCCCCCCCCCCCC	52.54	24816145
2134	Phosphorylation	FMKNRDVYSSDYFSF CCCCCCCCCCHHHHH	13.52	-
2138	Phosphorylation	RDVYSSDYFSFVLSL CCCCCCHHHHHHHHH	11.76	-
2148	Ubiquitination	FVLSLASLNATKLKH HHHHHHHCCCCCCCC	4.15	24816145
2149	Ubiquitination	VLSLASLNATKLKHP HHHHHHCCCCCCCCC	42.97	24816145
2154	Ubiquitination	SLNATKLKHPYYPCM HCCCCCCCCCCCHHH	44.05	32015554
2157	Phosphorylation	ATKLKHPYYPCMAKV CCCCCCCCCHHHHHH	21.54	-
2158	Phosphorylation	TKLKHPYYPCMAKVS CCCCCCCCHHHHHHH	8.39	-
2165	Phosphorylation	YPCMAKVSLQLAIQF CHHHHHHHHHHHHHH	15.08	28509920
2176	Phosphorylation	AIQFLFQTYLRTKKK HHHHHHHHHHCCCCC	19.72	28509920
2294	Sumoylation	LFNTFVQKQGIRAGD HHHHHHHHCCCCHHH	45.23	-
2307	Phosphorylation	GDLLLRHSALRHMIS HHHHHHHHHHHHHHH	23.67	-
2330	Phosphorylation	NNQIRRWSSAQAREF CHHHHHCHHHHHHHH	17.62	27251275
2379	Ubiquitination	IAPSSPLLPLHEEVE CCCCCCCCCCHHHHH	4.88	23000965
2399	Ubiquitination	SEGKPYLLEVMFALR CCCCHHHHHHHHHHH	3.73	23000965
2497	Phosphorylation	HVDSSRCYQCVKFLV CCCHHHHHHHHHHHH	12.11	22461510
2533	Acetylation	WAVQWLQKKMSEHYW HHHHHHHHHHHHHCC	48.55	25953088
2536	Phosphorylation	QWLQKKMSEHYWTPQ HHHHHHHHHHCCCCC	30.05	21945579
2539	Phosphorylation	QKKMSEHYWTPQSNV HHHHHHHCCCCCCCC	13.61	21945579
2541	Phosphorylation	KMSEHYWTPQSNVSN HHHHHCCCCCCCCCC	12.32	21945579
2551	Phosphorylation	SNVSNETSTGKTFQR CCCCCCCCCCCCCCC	29.05	28555341
2552	Phosphorylation	NVSNETSTGKTFQRT CCCCCCCCCCCCCCC	50.55	28555341
2554	Ubiquitination	SNETSTGKTFQRTIS CCCCCCCCCCCCCCC	46.37	23000965
2555	Phosphorylation	NETSTGKTFQRTISA CCCCCCCCCCCCCCH	26.75	29514088
2559	Phosphorylation	TGKTFQRTISAQDTL CCCCCCCCCCHHHHH	14.43	29255136
2561	Phosphorylation	KTFQRTISAQDTLAY CCCCCCCCHHHHHHH	21.18	29255136
2565	Phosphorylation	RTISAQDTLAYATAL CCCCHHHHHHHHHHH	10.95	22167270
2568	Phosphorylation	SAQDTLAYATALLNE CHHHHHHHHHHHHHH	13.96	30266825
2570	Phosphorylation	QDTLAYATALLNEKE HHHHHHHHHHHHHHH	12.74	30266825
2573	Ubiquitination	LAYATALLNEKEQSG HHHHHHHHHHHHHCC	7.84	23000965
2574	Ubiquitination	AYATALLNEKEQSGS HHHHHHHHHHHHCCC	60.18	23000965
2579	Phosphorylation	LLNEKEQSGSSNGSE HHHHHHHCCCCCCCC	41.56	30266825
2581	Phosphorylation	NEKEQSGSSNGSESS HHHHHCCCCCCCCCC	26.36	30266825
2582	Phosphorylation	EKEQSGSSNGSESSP HHHHCCCCCCCCCCC	49.05	30266825
2585	Phosphorylation	QSGSSNGSESSPANE HCCCCCCCCCCCCCC	38.26	30266825
2587	Phosphorylation	GSSNGSESSPANENG CCCCCCCCCCCCCCC	43.23	20068231
2588	Phosphorylation	SSNGSESSPANENGD CCCCCCCCCCCCCCC	24.79	21815630
2602	Phosphorylation	DRHLQQGSESPMMIG CHHCCCCCCCCCHHH	30.48	23401153
2604	Phosphorylation	HLQQGSESPMMIGEL HCCCCCCCCCHHHHH	21.57	29255136
2613	Phosphorylation	MMIGELRSDLDDVDP CHHHHHHCCCCCCCC	55.97	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1616	S	Phosphorylation	Kinase	CDK1	P06493	PSP
2047	S	Phosphorylation	Kinase	CDK1	P06493	PSP
2604	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DDB2_HUMAN	DDB2	physical	23159851
P53_HUMAN	TP53	physical	25578727

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP24_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047; SER-2561 ANDTHR-2565, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141; SER-2047; THR-2565AND SER-2604, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047; SER-2077 ANDSER-2604, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2604, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141 AND SER-2047, ANDMASS SPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1620, AND MASSSPECTROMETRY.	17525332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2047, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1616 AND SER-2047, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1943; TYR-2024 ANDTHR-2559, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2024, AND MASSSPECTROMETRY.	15144186 [Abstract]