BSPRY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BSPRY_HUMAN
• UniProt AC: Q5W0U4
• Protein Name: B box and SPRY domain-containing protein
• Gene Name: BSPRY
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: May regulate epithelial calcium transport by inhibiting TRPV5 activity..
• Protein Sequence: MSAEGAEPGPGSGSGPGPGPLCPEHGQALSWFCGSERRPVCAACAGLGGRCRGHRIRRAEERAEELRNKIVDQCERLQLQSAAITKYVADVLPGKNQRAVSMASAARELVIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRVHWAEALQKLDTIRTGLVGMLTHLDDLQLIQKEQEIFERTEEAEGILDPQESEMLNFNEKCTRSPLLTQLWATAVLGSLSGTEDIRIDERTVSPFLQLSDDRKTLTFSTKKSKACADGPERFDHWPNALAATSFQNGLHAWMVNVQNSCAYKVGVASGHLPRKGSGSDCRLGHNAFSWVFSRYDQEFRFSHNGQHEPLGLLRGPAQLGVVLDLQVQELLFYEPASGTVLCAHHVSFPGPLFPVFAVADQTISIVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAEGAEPG ------CCCCCCCCC	34.72	28348404
69	Ubiquitination	RAEELRNKIVDQCER HHHHHHHHHHHHHHH	37.36	-
95	Ubiquitination	VADVLPGKNQRAVSM HHHHCCCCCHHHHHH	48.22	-
101	Phosphorylation	GKNQRAVSMASAARE CCCHHHHHHHHHHHH	13.98	27251275
115	Phosphorylation	ELVIQRLSLVRSLCE HHHHHHHHHHHHHCH	27.32	24719451
156	Ubiquitination	HWAEALQKLDTIRTG HHHHHHHHHHHHHHC	49.53	-
207	Ubiquitination	EMLNFNEKCTRSPLL HCCCCCCHHCCCHHH	41.85	-
211	Phosphorylation	FNEKCTRSPLLTQLW CCCHHCCCHHHHHHH	11.18	-
240	Phosphorylation	RIDERTVSPFLQLSD CCCCEEECCCCCCCC	14.88	23403867
250	Acetylation	LQLSDDRKTLTFSTK CCCCCCCCEEEEECC	55.68	7408791
253	Phosphorylation	SDDRKTLTFSTKKSK CCCCCEEEEECCCCC	22.29	-
255	Phosphorylation	DRKTLTFSTKKSKAC CCCEEEEECCCCCCC	33.80	-
257	Acetylation	KTLTFSTKKSKACAD CEEEEECCCCCCCCC	54.58	19825717
258	Ubiquitination	TLTFSTKKSKACADG EEEEECCCCCCCCCC	58.22	-
259	Phosphorylation	LTFSTKKSKACADGP EEEECCCCCCCCCCH	27.35	-
399	Phosphorylation	AVADQTISIVR---- EEECCEEEECC----	20.58	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BSPRY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BSPRY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BSPRY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP55_HUMAN	CEP55	physical	28514442
DEAF1_HUMAN	DEAF1	physical	28514442
RN135_HUMAN	RNF135	physical	28514442
TMF1_HUMAN	TMF1	physical	28514442
HAUS4_HUMAN	HAUS4	physical	28514442
MBLC2_HUMAN	MBLAC2	physical	28514442
HAUS1_HUMAN	HAUS1	physical	28514442
UBP4_HUMAN	USP4	physical	28514442
HSBP1_HUMAN	HSBP1	physical	28514442
FEM1B_HUMAN	FEM1B	physical	28514442
OSBL1_HUMAN	OSBPL1A	physical	28514442
SEMG2_HUMAN	SEMG2	physical	28514442
BTBD9_HUMAN	BTBD9	physical	28514442
MTG8_HUMAN	RUNX1T1	physical	28514442
BAP18_HUMAN	C17orf49	physical	28514442
KLH23_HUMAN	KLHL23	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442
CENPH_HUMAN	CENPH	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.