RN135_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN135_HUMAN
• UniProt AC: Q8IUD6
• Protein Name: E3 ubiquitin-protein ligase RNF135
• Gene Name: RNF135
• Organism: Homo sapiens (Human).
• Sequence Length: 432
• Subcellular Localization: Cytoplasm .
• Protein Description: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production..
• Protein Sequence: MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHCLEALWGARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAHCPCPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVRSLQNQRPLSESGPDNELSILGKAFSSGVDLSMASPKLVTSDTAAGKIRDILHDLEEIQEKLQESVTWKEAPEAQMQGELLEAPSSSSCPLPDQSHPALRRASRFAQWAIHPTFNLKSLSCSLEVSKDSRTVTVSHRPQPYRWSCERFSTSQVLCSQALSSGKHYWEVDTRNCSHWAVGVASWEMSRDQVLGRTMDSCCVEWKGTSQLSAWHMVKETVLGSDRPGVVGIWLNLEEGKLAFYSVDNQEKLLYECTISASSPLYPAFWLYGLHPGNYLIIKQVKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	QPHLRKNTLLQDLAD CCHHHHCHHHHHHHH	31.70	28857561
84	Ubiquitination	LLQDLADKYRRAARE HHHHHHHHHHHHHHH	34.74	-
151	Phosphorylation	HLVDIVRSLQNQRPL HHHHHHHHHHHCCCC	24.34	28102081
159	Phosphorylation	LQNQRPLSESGPDNE HHHCCCCCCCCCCCC	32.19	28450419
161	Phosphorylation	NQRPLSESGPDNELS HCCCCCCCCCCCCHH	52.85	28450419
175	Phosphorylation	SILGKAFSSGVDLSM HHHHHHHHCCCCHHH	30.92	24719451
176	Phosphorylation	ILGKAFSSGVDLSMA HHHHHHHCCCCHHHC	36.06	28348404
181	Phosphorylation	FSSGVDLSMASPKLV HHCCCCHHHCCCCEE	14.08	29255136
184	Phosphorylation	GVDLSMASPKLVTSD CCCHHHCCCCEECCC	17.58	29255136
186	Ubiquitination	DLSMASPKLVTSDTA CHHHCCCCEECCCCH	53.76	-
189	Phosphorylation	MASPKLVTSDTAAGK HCCCCEECCCCHHHH	31.18	24702127
190	O-linked_Glycosylation	ASPKLVTSDTAAGKI CCCCEECCCCHHHHH	26.03	30059200
190	Phosphorylation	ASPKLVTSDTAAGKI CCCCEECCCCHHHHH	26.03	24702127
192	Phosphorylation	PKLVTSDTAAGKIRD CCEECCCCHHHHHHH	20.41	24702127
196	Ubiquitination	TSDTAAGKIRDILHD CCCCHHHHHHHHHHC	29.82	-
228 (in isoform 3)	Phosphorylation	-	33.03	-
228	Phosphorylation	PEAQMQGELLEAPSS CHHHHCCCEECCCCC	33.03	-
275	Phosphorylation	LSCSLEVSKDSRTVT EEEEEEECCCCCEEE	22.75	-
282	Phosphorylation	SKDSRTVTVSHRPQP CCCCCEEEEECCCCC	18.71	28857561
400	Phosphorylation	DNQEKLLYECTISAS CCHHEEEEEEEEECC	21.28	25072903
403	Phosphorylation	EKLLYECTISASSPL HEEEEEEEEECCCCC	13.16	25072903
405	Phosphorylation	LLYECTISASSPLYP EEEEEEEECCCCCCH	12.16	25072903
407	Phosphorylation	YECTISASSPLYPAF EEEEEECCCCCCHHH	26.21	25072903
408	Phosphorylation	ECTISASSPLYPAFW EEEEECCCCCCHHHE	20.74	25072903
411	Phosphorylation	ISASSPLYPAFWLYG EECCCCCCHHHEEEE	8.90	25072903
417	Phosphorylation	LYPAFWLYGLHPGNY CCHHHEEEECCCCCE	14.29	25072903
424	Phosphorylation	YGLHPGNYLIIKQVK EECCCCCEEEEEEEE	12.75	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN135_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN135_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN135_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX58_HUMAN	DDX58	physical	19484123
UB2D2_HUMAN	UBE2D2	physical	19484123
RN135_HUMAN	RNF135	physical	25416956
DDX58_HUMAN	DDX58	physical	19017631
CTNL1_HUMAN	CTNNAL1	physical	28514442
IQCB1_HUMAN	IQCB1	physical	28514442
TF2H2_HUMAN	GTF2H2	physical	28514442
XRCC4_HUMAN	XRCC4	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
TES_HUMAN	TES	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.