MBLC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBLC2_HUMAN
• UniProt AC: Q68D91
• Protein Name: Metallo-beta-lactamase domain-containing protein 2
• Gene Name: MBLAC2
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Protein Sequence: MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSSGLLQDREAKEDAARRPLLAVATHVHFDHSGGLYQFDRVAVHHAEAEALARGDNFETVTWLSDSEVVRTPSPGWRARQFRVQAVQPTLILQDGDVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNSRTSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSALEWYAH ------CCHHHHHHH	41.37	25944712
58	Phosphorylation	RSLPEYLYSSGLLQD HCHHHHHHHCCCCCC	10.41	27642862
121	Phosphorylation	FETVTWLSDSEVVRT CEEEEEECCCCEEEC	30.56	-
130	Phosphorylation	SEVVRTPSPGWRARQ CCEEECCCCCCCCEE	35.12	24719451
166 (in isoform 2)	Phosphorylation	-	18.23	-
221	Methylation	RLIELVDRGLVEKVL HHHHHHHCCHHHHHC	32.63	115482743
226	Ubiquitination	VDRGLVEKVLPGHFN HHCCHHHHHCCCCCC	41.41	21890473
226 (in isoform 1)	Ubiquitination	-	41.41	21890473
234	Phosphorylation	VLPGHFNTFGAERLF HCCCCCCCCCHHHHH	23.62	22210691
250	Ubiquitination	LASNYISKAGICHKV HHHHHHHHCCCCHHH	40.86	-
254	S-palmitoylation	YISKAGICHKVSTFA HHHHCCCCHHHHHHH	2.19	21044946
256 (in isoform 1)	Ubiquitination	-	33.21	21890473
256	Ubiquitination	SKAGICHKVSTFAMR HHCCCCHHHHHHHHH	33.21	21890473
258	Phosphorylation	AGICHKVSTFAMRSL CCCCHHHHHHHHHHH	23.70	29523821
259	Phosphorylation	GICHKVSTFAMRSLA CCCHHHHHHHHHHHH	20.57	29523821
264	Phosphorylation	VSTFAMRSLASLALR HHHHHHHHHHHHHHH	18.40	22210691
267	Phosphorylation	FAMRSLASLALRVTN HHHHHHHHHHHHHHC	21.33	29523821
273	Phosphorylation	ASLALRVTNSRTSP- HHHHHHHHCCCCCC-	22.50	22210691
275	Phosphorylation	LALRVTNSRTSP--- HHHHHHCCCCCC---	27.80	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBLC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBLC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBLC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCN7_HUMAN	CLCN7	physical	28514442
SL9A6_HUMAN	SLC9A6	physical	28514442
TM230_HUMAN	TMEM230	physical	28514442
FLRT3_HUMAN	FLRT3	physical	28514442
EPHA7_HUMAN	EPHA7	physical	28514442
BCS1_HUMAN	BCS1L	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
BL1S3_HUMAN	BLOC1S3	physical	28514442
GMCL1_HUMAN	GMCL1	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
STEA3_HUMAN	STEAP3	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
JAM1_HUMAN	F11R	physical	28514442
ZDH20_HUMAN	ZDHHC20	physical	28514442
TP4A1_HUMAN	PTP4A1	physical	28514442
TM192_HUMAN	TMEM192	physical	28514442
ATRAP_HUMAN	AGTRAP	physical	28514442
CNNM4_HUMAN	CNNM4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.