SL9A6_HUMAN - dbPTM
SL9A6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SL9A6_HUMAN
UniProt AC Q92581
Protein Name Sodium/hydrogen exchanger 6
Gene Name SLC9A6
Organism Homo sapiens (Human).
Sequence Length 669
Subcellular Localization Endosome membrane
Multi-pass membrane protein . Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.
Protein Description Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis..
Protein Sequence MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationPLRRGVGSSPRARRL
CCCCCCCCCHHHHHH		34.46-
88 (in isoform 3)Phosphorylation-2.42-
95 (in isoform 3)Phosphorylation-29.81-
128N-linked_GlycosylationHVPSDVNNVTLSCEV
CCCCCCCCEEEEEEE		28.1819159218
140 (in isoform 2)Phosphorylation-31.83-
147 (in isoform 2)Phosphorylation-29.14-
166PhosphorylationIIFYAGYSLKRRHFF
HHHHCCCCHHHHHHH		26.8824719451
443UbiquitinationLNLGRRSKIGSNFQH
HHCCCCCCCCCHHHH		49.6417370265
446PhosphorylationGRRSKIGSNFQHMMM
CCCCCCCCHHHHHHH		37.6330631047
480PhosphorylationYARQMMFSTTLLIVF
HHHHHHHHHHHHHHH		11.5524043423
481PhosphorylationARQMMFSTTLLIVFF
HHHHHHHHHHHHHHH		15.3624043423
482PhosphorylationRQMMFSTTLLIVFFT
HHHHHHHHHHHHHHH		20.5424043423
489PhosphorylationTLLIVFFTVWVFGGG
HHHHHHHHHHHHCCH		11.2924043423
497PhosphorylationVWVFGGGTTAMLSCL
HHHHCCHHHHHHHHH		18.0424043423
498PhosphorylationWVFGGGTTAMLSCLH
HHHCCHHHHHHHHHE		17.2224043423
502PhosphorylationGGTTAMLSCLHIRVG
CHHHHHHHHHEEEEC		11.1024043423
528UbiquitinationENERRTTKAESAWLF
CCHHCCCHHHHHHHH		49.93-
560 (in isoform 2)Ubiquitination-26.05-
573PhosphorylationGPIARCLTSPQAYEN
HHHHHHCCCHHHHCC		41.8225159151
574PhosphorylationPIARCLTSPQAYENQ
HHHHHCCCHHHHCCH		11.3221815630
589PhosphorylationEQLKDDDSDLILNDG
HHHCCCCCCCEECCC		41.1125849741
599PhosphorylationILNDGDISLTYGDST
EECCCCEEEEECCCC		21.2825159151
601PhosphorylationNDGDISLTYGDSTVN
CCCCEEEEECCCCCC		20.7620639409
602PhosphorylationDGDISLTYGDSTVNT
CCCEEEEECCCCCCC		24.9920639409
605PhosphorylationISLTYGDSTVNTEPA
EEEEECCCCCCCCCC		29.8620639409
606PhosphorylationSLTYGDSTVNTEPAT
EEEECCCCCCCCCCC		23.6320639409
609PhosphorylationYGDSTVNTEPATSSA
ECCCCCCCCCCCCCC		38.7220639409
613PhosphorylationTVNTEPATSSAPRRF
CCCCCCCCCCCCCHH		33.6520639409
614PhosphorylationVNTEPATSSAPRRFM
CCCCCCCCCCCCHHC		26.9820639409
615PhosphorylationNTEPATSSAPRRFMG
CCCCCCCCCCCHHCC		37.6320639409
624PhosphorylationPRRFMGNSSEDALDR
CCHHCCCCCHHHHHH		29.4026657352
625PhosphorylationRRFMGNSSEDALDRE
CHHCCCCCHHHHHHH		43.4223911959
654PhosphorylationLVLPMDDSEPPLNLL
EEEECCCCCCCCCCC		47.9728450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SL9A6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SL9A6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SL9A6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SL9A7_HUMANSLC9A7physical
28514442
FUT8_HUMANFUT8physical
28514442
BROMI_HUMANTBC1D32physical
28514442
CDK20_HUMANCDK20physical
28514442
RAC3_HUMANRAC3physical
28514442
DJC30_HUMANDNAJC30physical
28514442
COA1_HUMANCOA1physical
28514442
PMGT2_HUMANPOMGNT2physical
28514442
PLD6_HUMANPLD6physical
28514442
AL3B1_HUMANALDH3B1physical
28514442
MA2A2_HUMANMAN2A2physical
28514442
FGFR2_HUMANFGFR2physical
28514442
FKRP_HUMANFKRPphysical
28514442
S19A2_HUMANSLC19A2physical
28514442
INGR1_HUMANIFNGR1physical
28514442
SERC1_HUMANSERINC1physical
28514442
TM164_HUMANTMEM164physical
28514442
TM87A_HUMANTMEM87Aphysical
28514442
MP3B2_HUMANMAP1LC3B2physical
28514442
AL3A2_HUMANALDH3A2physical
28514442
YIPF3_HUMANYIPF3physical
28514442
Drug and Disease Associations
Kegg Disease
H00577 Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part
OMIM Disease
300243Mental retardation, X-linked, syndromic, Christianson type (MRXSCH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SL9A6_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-128, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-625, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-443, AND MASSSPECTROMETRY.

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