SL9A7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SL9A7_HUMAN
• UniProt AC: Q96T83
• Protein Name: Sodium/hydrogen exchanger 7
• Gene Name: SLC9A7
• Organism: Homo sapiens (Human).
• Sequence Length: 725
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
• Protein Description: Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis..
• Protein Sequence: MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVNANVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVFPLEDNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GDAARPGSGRATGAP CCCCCCCCCCCCCCC	27.99	22210691
131	Phosphorylation	SGRDKSLSCTQEDRA CCCCCCCCCCHHHHH	23.39	-
145	N-linked_Glycosylation	AFSTLLVNVSGKFFE HHEEEEEECCCCEEE	23.39	11279194
145	N-linked_Glycosylation	AFSTLLVNVSGKFFE HHEEEEEECCCCEEE	23.39	19349973
160	Phosphorylation	YTLKGEISPGKINSV EEECCCCCCCCCCCC	24.25	24719451
197	Phosphorylation	PIIFHAGYSLKKRHF HHHHHCCCCCHHHHH	16.18	-
198	Phosphorylation	IIFHAGYSLKKRHFF HHHHCCCCCHHHHHH	32.56	24719451
244	Phosphorylation	MKIMGQLSDKFYYTD HHHHHHCCCCCCCCC	30.76	28961369
545	Phosphorylation	RVGVEEPSEEDQNEH EECCCCCCHHHCCCC	57.82	30266825
556	Phosphorylation	QNEHHWQYFRVGVDP CCCCCCEEEEEECCC	6.53	28796482
573	Phosphorylation	DPPPNNDSFQVLQGD CCCCCCCCCEEEECC	21.50	26657352
691	Phosphorylation	SLEGSRRTKSSSEEV CCCCCCCCCCCCHHH	33.88	30108239
692	Ubiquitination	LEGSRRTKSSSEEVL CCCCCCCCCCCHHHH	46.67	-
693	Phosphorylation	EGSRRTKSSSEEVLE CCCCCCCCCCHHHHH	38.18	23401153
694	Phosphorylation	GSRRTKSSSEEVLER CCCCCCCCCHHHHHH	43.24	30278072
695	Phosphorylation	SRRTKSSSEEVLERD CCCCCCCCHHHHHHH	44.88	20164059
709	Ubiquitination	DLGMGDQKVSSRGTR HCCCCCCCCCCCCCE	49.15	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SL9A7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SL9A7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SL9A7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SL9A7_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-695, AND MASSSPECTROMETRY.
PubMed: 19690332