BROMI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BROMI_HUMAN
• UniProt AC: Q96NH3
• Protein Name: Protein broad-minded
• Gene Name: TBC1D32
• Organism: Homo sapiens (Human).
• Sequence Length: 1257
• Subcellular Localization: Cytoplasm. Cell projection, cilium.
• Protein Description: Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity)..
• Protein Sequence: MAHFSSEDQAMLQAMLRRLFQSVKEKITGAPSLECAEEILLHLEETDENFHNYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYDTVVQQVTKRTQESKEYKEMMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKFCQGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHNQSHVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKADETLGHSKHCRNKQKTFYYLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTSAAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNSSEESPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSDSVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAGGIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLLSYPAIYELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNYRTVLLRDMRNIRLQST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Ubiquitination	TVVQQVTKRTQESKE HHHHHHHHHHHHCHH	55.37	29967540
107	Phosphorylation	RTQESKEYKEMMHYL HHHHCHHHHHHHHHH	18.91	29507054
113	Phosphorylation	EYKEMMHYLKNIMIA HHHHHHHHHHHHHHH	11.07	29507054
150	Phosphorylation	IQKEKSHSYRTDNCS HHHHHHHCCCCCCCC	24.33	29496907
153	Phosphorylation	EKSHSYRTDNCSDSD HHHHCCCCCCCCCCC	24.27	29496907
168	Ubiquitination	SSLNQSYKFCQGKLQ CCHHHHHHHHHHHHH	44.93	-
168 (in isoform 4)	Ubiquitination	-	44.93	-
219	Phosphorylation	TTLCEKLTVSLSDPD HHHHHHHHEECCCCC	21.08	-
221	Phosphorylation	LCEKLTVSLSDPDPV HHHHHHEECCCCCCC	19.54	-
300 (in isoform 1)	Ubiquitination	-	55.75	21906983
300 (in isoform 4)	Ubiquitination	-	55.75	21906983
300	Ubiquitination	RLLNEYQKEAPSFWI HHHHHHHHHCCCCCC	55.75	21906983
323	Phosphorylation	EIVESTLSLLTVKHN HHHHHHHHHHHCCCC	22.78	26437602
352 (in isoform 4)	Ubiquitination	-	36.16	21906983
352 (in isoform 1)	Ubiquitination	-	36.16	21906983
352	Ubiquitination	FFALVDTKAVWFKKW HHEEECCCHHHHHHH	36.16	21906983
574	Phosphorylation	LYGANMNSSEESPTG HHHCCCCCCCCCCCC	28.49	-
589	Phosphorylation	AHIIAQFSKKLLDED HHHHHHHHHHHCCCC	19.46	27732954
746 (in isoform 1)	Ubiquitination	-	35.55	21906983
746 (in isoform 4)	Ubiquitination	-	35.55	21906983
746	Ubiquitination	AAGGIALKKSGFINE CCCCHHHHHCCHHHH	35.55	21906983
747	Ubiquitination	AGGIALKKSGFINEL CCCHHHHHCCHHHHH	57.57	-
747 (in isoform 4)	Ubiquitination	-	57.57	-
785	Phosphorylation	PVDPIDRSCQKSFLA CCCCCCHHHHHHHHH	19.70	-
789	Phosphorylation	IDRSCQKSFLALVNL CCHHHHHHHHHHHHH	10.30	-
814 (in isoform 1)	Ubiquitination	-	40.57	21906983
814	Ubiquitination	RNQDLPNKTEYSLRE HCCCCCCCCCCCHHC	40.57	2190698
814 (in isoform 4)	Ubiquitination	-	40.57	21906983
815	Phosphorylation	NQDLPNKTEYSLREV CCCCCCCCCCCHHCC	46.96	28674151
817	Phosphorylation	DLPNKTEYSLREVPT CCCCCCCCCHHCCCH	20.45	28674151
818	Phosphorylation	LPNKTEYSLREVPTC CCCCCCCCHHCCCHH	18.08	24719451
865	Phosphorylation	DFIIDGLSVERNHVL HHEEECCCEECCEEE	27.71	24719451
923	Ubiquitination	ITRNAGIKQDNDLDK HHHCCCCCCCCCHHH	51.16	27667366
938	Phosphorylation	LLLCLKISDKQTEWI HHHEEECCHHHHHHH	36.85	26074081
940	Ubiquitination	LCLKISDKQTEWIEN HEEECCHHHHHHHHH	52.94	29967540
942	Phosphorylation	LKISDKQTEWIENCQ EECCHHHHHHHHHHH	38.74	26074081
964	Ubiquitination	KAKPDIISGEALIEL CCCCCCCCHHHHHHH	30.80	27667366
981 (in isoform 4)	Ubiquitination	-	67.99	-
1024	Phosphorylation	VRYGKFLSLLKDGAE EECHHHHHHHCCCCC	34.49	24719451
1039	Ubiquitination	NDLTWVLKHCERFLK CCHHHHHHHHHHHHH	36.27	29967540
1046	Ubiquitination	KHCERFLKQQQTSIK HHHHHHHHHHHHHHH	43.26	29967540
1243	Phosphorylation	ILEQNYRTVLLRDMR HHHHHHHHHHHHHHH	12.73	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BROMI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BROMI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BROMI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	27173435
XYLT2_HUMAN	XYLT2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.