XYLT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XYLT2_HUMAN
• UniProt AC: Q9H1B5
• Protein Name: Xylosyltransferase 2
• Gene Name: XYLT2
• Organism: Homo sapiens (Human).
• Sequence Length: 865
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans. [PubMed: 26027496 Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity Its enzyme activity has not been demonstrated.]
• Protein Sequence: MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEAGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSTGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALVGAAGFPPHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGGASLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENTYDAADGPSGLSDVMLTAYTAFARLSLHHAATAAPPMGTPLCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQGSLKLLGRSDQASRLQSLEVGTDWDPKERLFRNFGGLLGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWSSLSPDPKSELGPVKADGRLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	O-linked_Glycosylation	PLDPGEGSKDTDSSA CCCCCCCCCCCCCCC	24.05	55830913
64	O-linked_Glycosylation	PGEGSKDTDSSAGRR CCCCCCCCCCCCCCC	41.33	55830919
66	O-linked_Glycosylation	EGSKDTDSSAGRRGS CCCCCCCCCCCCCCC	24.95	OGP
67	O-linked_Glycosylation	GSKDTDSSAGRRGST CCCCCCCCCCCCCCC	37.24	55830925
76	Methylation	GRRGSTGRRHGRWRG CCCCCCCCCCCCCCC	27.75	24388137
87	O-linked_Glycosylation	RWRGRAESPGVPVAK CCCCCCCCCCCCHHH	26.43	55834723
100	Phosphorylation	AKVVRAVTSRQRASR HHHHHHHHHHHHHHC	19.73	-
122	N-linked_Glycosylation	PEAPGRQNLSGAAAG CCCCCCCCCCCHHHH	34.51	UniProtKB CARBOHYD
154	O-linked_Glycosylation	VEGAPQPTDNGFTPK CCCCCCCCCCCCCCC	36.53	OGP
221	O-linked_Glycosylation	PGIQWDESQAQQPMD CCCCCCHHHCCCCCC	28.48	OGP
256	Phosphorylation	KRLLKAVYHEQHFFY HHHHHHHHCCCCEEE	12.42	-
284	Phosphorylation	VVELAQGYDNVRVTP HHHHHCCCCCCEECC	7.71	25884760
327	N-linked_Glycosylation	WAWDFFINLSATDYP CEEEEEEEECCCCCC	23.84	UniProtKB CARBOHYD
355	Ubiquitination	NRDKNFLKSHGRDNS CCCHHHHHHCCCCHH	35.95	-
464	Ubiquitination	RVTNWNRKLGCKCQY EECCCCHHCCCCCCC	46.12	-
468	Ubiquitination	WNRKLGCKCQYKHIV CCHHCCCCCCCCEEC	23.68	-
536	Phosphorylation	GTPALKAYWENTYDA CCHHHHHHHHCCCCC	16.21	-
571	Phosphorylation	LSLHHAATAAPPMGT HHHHHHHHCCCCCCC	24.92	25627689
571	O-linked_Glycosylation	LSLHHAATAAPPMGT HHHHHHHHCCCCCCC	24.92	55829223
637	Phosphorylation	SLKLLGRSDQASRLQ CCEECCCCHHHHHHH	32.07	23879269
645	Phosphorylation	DQASRLQSLEVGTDW HHHHHHHHCCCCCCC	30.96	23879269
683	N-linked_Glycosylation	QRWARGPNLTATVVW HHHHCCCCCEEEEEE	53.50	UniProtKB CARBOHYD
777	O-linked_Glycosylation	HNEYMEQSFQGLSSI CHHHHHHHHHHHHHH	13.26	OGP
782	O-linked_Glycosylation	EQSFQGLSSILNLPQ HHHHHHHHHHHCCCC	23.35	OGP
783	O-linked_Glycosylation	QSFQGLSSILNLPQP HHHHHHHHHHCCCCH	35.82	OGP
801	O-linked_Glycosylation	EEAAQRHTQLTGPAL HHHHHHHHHCCHHHH	27.71	OGP
848	Phosphorylation	LTSWSSLSPDPKSEL CCCHHHCCCCCCHHC	29.25	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XYLT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XYLT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XYLT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	27173435
MTA2_HUMAN	MTA2	physical	27173435
TAF6L_HUMAN	TAF6L	physical	27173435
FOXJ1_HUMAN	FOXJ1	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.