| UniProt ID | FOXJ1_HUMAN | |
|---|---|---|
| UniProt AC | Q92949 | |
| Protein Name | Forkhead box protein J1 {ECO:0000305} | |
| Gene Name | FOXJ1 {ECO:0000312|HGNC:HGNC:3816} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 421 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T).. | |
| Protein Sequence | MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPHGYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGAFL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 174 | Phosphorylation | NSIRHNLSLNKCFIK HHHHHCCCCCCEEEE | 34.90 | 21712546 | |
| 207 | Phosphorylation | QYAERLLSGAFKKRR HHHHHHHHHHHHCCC | 32.44 | 23898821 | |
| 233 | Phosphorylation | RQAAQEPSAVPRAGP HHHHHCCCCCCCCCC | 40.94 | 23532336 | |
| 290 | Phosphorylation | AKVPRPPSTLLPTPE CCCCCCCCCCCCCHH | 34.08 | 27251275 | |
| 291 | Phosphorylation | KVPRPPSTLLPTPEE CCCCCCCCCCCCHHH | 37.78 | 27251275 | |
| 295 | Phosphorylation | PPSTLLPTPEEQGEL CCCCCCCCHHHHCCC | 43.21 | 26853621 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FOXJ1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FOXJ1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FOXJ1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TWF2_HUMAN | TWF2 | physical | 21988832 | |
| TRM6_HUMAN | TRMT6 | physical | 21988832 | |
| THA_HUMAN | THRA | physical | 21988832 | |
| MS18B_HUMAN | OIP5 | physical | 21988832 | |
| NMRL1_HUMAN | NMRAL1 | physical | 21988832 | |
| SPX3_HUMAN | SLC37A3 | physical | 21988832 | |
| RUSD1_HUMAN | RPUSD1 | physical | 21988832 | |
| RFX1_HUMAN | RFX1 | physical | 25609649 | |
| BROMI_HUMAN | TBC1D32 | physical | 25609649 | |
| CDK20_HUMAN | CDK20 | physical | 25609649 | |
| FBX11_HUMAN | FBXO11 | physical | 25609649 | |
| CFA20_HUMAN | CFAP20 | physical | 25609649 | |
| RFX3_HUMAN | RFX3 | physical | 25609649 | |
| RFX2_HUMAN | RFX2 | physical | 25609649 | |
| ACSL4_HUMAN | ACSL4 | physical | 25609649 | |
| TM9S3_HUMAN | TM9SF3 | physical | 25609649 | |
| BROMI_HUMAN | TBC1D32 | physical | 28514442 | |
| RFX1_HUMAN | RFX1 | physical | 28514442 | |
| RFX3_HUMAN | RFX3 | physical | 28514442 | |
| CDK20_HUMAN | CDK20 | physical | 28514442 | |
| RFX2_HUMAN | RFX2 | physical | 28514442 | |
| PEX14_HUMAN | PEX14 | physical | 28514442 | |
| ASPM_HUMAN | ASPM | physical | 28514442 | |
| FBX11_HUMAN | FBXO11 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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