CFA20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA20_HUMAN
• UniProt AC: Q9Y6A4
• Protein Name: Cilia- and flagella-associated protein 20
• Gene Name: CFAP20
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium.
• Protein Description: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. [PubMed: 24414207 Required for axonemal microtubules polyglutamylation]
• Protein Sequence: MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLLDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKAKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	SILYSIGSKPLQIWD HHHHHCCCCCCEEEC		24719451
27	Ubiquitination	KPLQIWDKKVRNGHI CCCEEECHHCCCCCE		29967540
27	Acetylation	KPLQIWDKKVRNGHI CCCEEECHHCCCCCE		23236377
86	Phosphorylation	IIKNLKKYFTFEVQV HHHCHHHEEEEEEEE		22817900
110	Phosphorylation	FRASNYQSTTRVKPF HHHCCCCCCCCEECE		30622161
111	Phosphorylation	RASNYQSTTRVKPFI HHCCCCCCCCEECEE		30622161
112	Phosphorylation	ASNYQSTTRVKPFIC HCCCCCCCCEECEEE		30622161
115	Ubiquitination	YQSTTRVKPFICTMP CCCCCCEECEEEECC		23000965
115	Acetylation	YQSTTRVKPFICTMP CCCCCCEECEEEECC		26051181
120	Phosphorylation	RVKPFICTMPMRLDD CEECEEEECCEEECC		-
170	Methylation	RRVYFSDRLYSEDEL EEEEECCCCCCCCCC		-
173	Phosphorylation	YFSDRLYSEDELPAE EECCCCCCCCCCCCE		-
182	Ubiquitination	DELPAEFKLYLPVQN CCCCCEEEEEEECCC		22817900
184	Phosphorylation	LPAEFKLYLPVQNKA CCCEEEEEEECCCCC		28796482
184	Nitration	LPAEFKLYLPVQNKA CCCEEEEEEECCCCC		-
190	Acetylation	LYLPVQNKAKQ---- EEEECCCCCCC----		25953088
190	Ubiquitination	LYLPVQNKAKQ---- EEEECCCCCCC----		32015554
192	Ubiquitination	LPVQNKAKQ------ EECCCCCCC------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2L1_HUMAN	TFCP2L1	physical	21988832
SFSWA_HUMAN	SFSWAP	physical	26472758
CLASR_HUMAN	CLASRP	physical	26472758
U2AF1_HUMAN	U2AF1	physical	26472758
SFSWA_HUMAN	SFSWAP	physical	28514442
BROMI_HUMAN	TBC1D32	physical	28514442
CDK20_HUMAN	CDK20	physical	28514442
AR2BP_HUMAN	ARL2BP	physical	28514442
CLASR_HUMAN	CLASRP	physical	28514442
RABEK_HUMAN	RABEPK	physical	28514442
F149B_HUMAN	FAM149B1	physical	28514442
CK084_HUMAN	C11orf84	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
PININ_HUMAN	PNN	physical	28514442
PR40A_HUMAN	PRPF40A	physical	28514442
RBM25_HUMAN	RBM25	physical	28514442
CDK20_HUMAN	CDK20	physical	27173435
BROMI_HUMAN	TBC1D32	physical	27173435
CLASR_HUMAN	CLASRP	physical	27173435
DCAF1_HUMAN	VPRBP	physical	27173435
TRBP2_HUMAN	TARBP2	physical	27173435
DICER_HUMAN	DICER1	physical	27173435
DDA1_HUMAN	DDA1	physical	27173435
PLK1_HUMAN	PLK1	physical	27173435
ODPB_HUMAN	PDHB	physical	27173435
HNRL1_HUMAN	HNRNPUL1	physical	27173435
SART3_HUMAN	SART3	physical	27173435
RT28_HUMAN	MRPS28	physical	27173435
RT35_HUMAN	MRPS35	physical	27173435
SMD3_HUMAN	SNRPD3	physical	27173435
RT31_HUMAN	MRPS31	physical	27173435
IMA3_HUMAN	KPNA4	physical	27173435
FOXJ1_HUMAN	FOXJ1	physical	27173435
PR38A_HUMAN	PRPF38A	physical	27173435
HSF1_HUMAN	HSF1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.