ODPB_HUMAN - dbPTM
ODPB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ODPB_HUMAN
UniProt AC P11177
Protein Name Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Gene Name PDHB
Organism Homo sapiens (Human).
Sequence Length 359
Subcellular Localization Mitochondrion matrix.
Protein Description The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle..
Protein Sequence MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAAVSGLVRRPL
---CCCHHHHCHHHH		22.9827461979
5O-linked_Glycosylation---MAAVSGLVRRPL
---CCCHHHHCHHHH		22.9825367160
26PhosphorylationLKRRFHWTAPAALQV
HHHHCCCCCCCEEEH		17.75-
34PhosphorylationAPAALQVTVRDAINQ
CCCEEEHHHHHHHHC		9.2523312004
43SulfoxidationRDAINQGMDEELERD
HHHHHCCCHHHHHHH		4.1721406390
49MethylationGMDEELERDEKVFLL
CCHHHHHHHCEEEEC		70.75115486787
50 (in isoform 2)Ubiquitination-51.17-
52AcetylationEELERDEKVFLLGEE
HHHHHHCEEEECCHH		42.4425038526
63PhosphorylationLGEEVAQYDGAYKVS
CCHHHHHCCCCCEEC		13.4525147952
67PhosphorylationVAQYDGAYKVSRGLW
HHHCCCCCEECCCHH		19.9021082442
68AcetylationAQYDGAYKVSRGLWK
HHCCCCCEECCCHHH		32.9523954790
682-HydroxyisobutyrylationAQYDGAYKVSRGLWK
HHCCCCCEECCCHHH		32.95-
85PhosphorylationGDKRIIDTPISEMGF
CCEEEEECCHHHCCC		16.4721601212
130PhosphorylationVINSAAKTYYMSGGL
HHHHHHHHHHHCCCC		18.37-
166UbiquitinationSQCFAAWYGHCPGLK
HHHHHHHHCCCCCCE		7.7121890473
166 (in isoform 2)Ubiquitination-7.7121890473
173AcetylationYGHCPGLKVVSPWNS
HCCCCCCEEECCCCC		46.6426051181
176PhosphorylationCPGLKVVSPWNSEDA
CCCCEEECCCCCHHH		27.47-
184UbiquitinationPWNSEDAKGLIKSAI
CCCCHHHHHHHHHHH		67.5821890473
184 (in isoform 1)Ubiquitination-67.5821890473
1842-HydroxyisobutyrylationPWNSEDAKGLIKSAI
CCCCHHHHHHHHHHH		67.58-
184UbiquitinationPWNSEDAKGLIKSAI
CCCCHHHHHHHHHHH		67.5821890473
1882-HydroxyisobutyrylationEDAKGLIKSAIRDNN
HHHHHHHHHHHHCCC		38.59-
188UbiquitinationEDAKGLIKSAIRDNN
HHHHHHHHHHHHCCC		38.59-
209 (in isoform 2)Ubiquitination-20.77-
227AcetylationDFLIPIGKAKIERQG
CEEEEECCCEEEECC		47.4225953088
227UbiquitinationDFLIPIGKAKIERQG
CEEEEECCCEEEECC		47.42-
229UbiquitinationLIPIGKAKIERQGTH
EEEECCCEEEECCCE		48.89-
258AcetylationEAAAVLSKEGVECEV
HHHHHHCCCCCEEEE		55.0925038526
263GlutathionylationLSKEGVECEVINMRT
HCCCCCEEEEEECCE		4.7422555962
268SulfoxidationVECEVINMRTIRPMD
CEEEEEECCEECCCC		2.4821406390
270PhosphorylationCEVINMRTIRPMDME
EEEEECCEECCCCHH		15.5720068231
278PhosphorylationIRPMDMETIEASVMK
ECCCCHHHHHHEEEC		19.9220068231
282O-linked_GlycosylationDMETIEASVMKTNHL
CHHHHHHEEECCCCE		15.2325367160
282PhosphorylationDMETIEASVMKTNHL
CHHHHHHEEECCCCE		15.2321406692
318 (in isoform 2)Ubiquitination-6.0321890473
318UbiquitinationEGPAFNFLDAPAVRV
HCCCCCCCCCCEEEE		6.0321890473
329 (in isoform 2)Ubiquitination-46.53-
336UbiquitinationDVPMPYAKILEDNSI
CCCCCHHHHHCCCCC		41.8221890473
336AcetylationDVPMPYAKILEDNSI
CCCCCHHHHHCCCCC		41.8223954790
336UbiquitinationDVPMPYAKILEDNSI
CCCCCHHHHHCCCCC		41.8221890473
336 (in isoform 1)Ubiquitination-41.8221890473
347AcetylationDNSIPQVKDIIFAIK
CCCCHHHHHHHHHHH		37.6525038526
347UbiquitinationDNSIPQVKDIIFAIK
CCCCHHHHHHHHHHH		37.65-
347SuccinylationDNSIPQVKDIIFAIK
CCCCHHHHHHHHHHH		37.6523954790
354AcetylationKDIIFAIKKTLNI--
HHHHHHHHHHHCC--		35.9519608861
354SuccinylationKDIIFAIKKTLNI--
HHHHHHHHHHHCC--		35.9523954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ODPB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ODPB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ODPB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ODPX_HUMANPDHXphysical
7864652
ODPA_HUMANPDHA1physical
7864652
ODPAT_HUMANPDHA2physical
7864652
ODPX_HUMANPDHXphysical
22939629
RSSA_HUMANRPSAphysical
22939629
PCY2_HUMANPCYT2physical
22863883
RRAGB_HUMANRRAGBphysical
22863883
1433E_HUMANYWHAEphysical
22863883
ODPX_HUMANPDHXphysical
26186194
DLDH_HUMANDLDphysical
26186194
PDK2_HUMANPDK2physical
26186194
PDK1_HUMANPDK1physical
26186194
PDK3_HUMANPDK3physical
26186194
PP2BB_HUMANPPP3CBphysical
26186194
PP2BC_HUMANPPP3CCphysical
26186194
PP2BA_HUMANPPP3CAphysical
26186194
ARMC8_HUMANARMC8physical
26186194
ODP2_HUMANDLATphysical
26186194
RMD5A_HUMANRMND5Aphysical
26186194
CANB1_HUMANPPP3R1physical
26186194
ODPA_HUMANPDHA1physical
26186194
GID4_HUMANGID4physical
26186194
BANP_HUMANBANPphysical
26186194
FHL2_HUMANFHL2physical
26186194
TP4A1_HUMANPTP4A1physical
26186194
COX5A_HUMANCOX5Aphysical
26344197
ODPA_HUMANPDHA1physical
26344197
ODPAT_HUMANPDHA2physical
26344197
PDK3_HUMANPDK3physical
28514442
PP2BC_HUMANPPP3CCphysical
28514442
ODPA_HUMANPDHA1physical
28514442
BANP_HUMANBANPphysical
28514442
PP2BB_HUMANPPP3CBphysical
28514442
CANB1_HUMANPPP3R1physical
28514442
ODPX_HUMANPDHXphysical
28514442
ODP2_HUMANDLATphysical
28514442
PP2BA_HUMANPPP3CAphysical
28514442
DLDH_HUMANDLDphysical
28514442
PDK1_HUMANPDK1physical
28514442
FHL2_HUMANFHL2physical
28514442
PDK2_HUMANPDK2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614111Pyruvate dehydrogenase E1-beta deficiency (PDHBD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00119Pyruvic acid
Regulatory Network of ODPB_HUMAN

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Related Literatures of Post-Translational Modification

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