PCY2_HUMAN - dbPTM
PCY2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCY2_HUMAN
UniProt AC Q99447
Protein Name Ethanolamine-phosphate cytidylyltransferase
Gene Name PCYT2
Organism Homo sapiens (Human).
Sequence Length 389
Subcellular Localization
Protein Description Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine..
Protein Sequence MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Methylation--MIRNGRGAAGGAE
--CCCCCCCCCCCCC		34.8212020089
34UbiquitinationCDGCYDMVHYGHSNQ
ECCCCCCCHHCCHHH		2.6221906983
46UbiquitinationSNQLRQARAMGDYLI
HHHHHHHHHHCCEEE		19.44-
66UbiquitinationDEEIAKHKGPPVFTQ
HHHHHHHCCCCCCCH		72.8521906983
78UbiquitinationFTQEERYKMVQAIKW
CCHHHHHHHHHHHHH		38.52-
84UbiquitinationYKMVQAIKWVDEVVP
HHHHHHHHHHHHHCC		44.15-
98UbiquitinationPAAPYVTTLETLDKY
CCCCEEEEHHHHHHC		16.7421906983
125PhosphorylationLTVDGRDTYEEVKQA
EEECCCCHHHHHHHH		31.3227732954
126PhosphorylationTVDGRDTYEEVKQAG
EECCCCHHHHHHHHC		17.8727732954
130UbiquitinationRDTYEEVKQAGRYRE
CCHHHHHHHHCCCHH		37.4021906983
141PhosphorylationRYRECKRTQGVSTTD
CCHHCCCCCCCCHHH		18.3720068231
145PhosphorylationCKRTQGVSTTDLVGR
CCCCCCCCHHHHHHH		32.2020068231
146PhosphorylationKRTQGVSTTDLVGRM
CCCCCCCHHHHHHHH		23.1720068231
147PhosphorylationRTQGVSTTDLVGRML
CCCCCCHHHHHHHHH		21.6020068231
147UbiquitinationRTQGVSTTDLVGRML
CCCCCCHHHHHHHHH		21.60-
157PhosphorylationVGRMLLVTKAHHSSQ
HHHHHHHHHCCCCCH		23.60-
162PhosphorylationLVTKAHHSSQEMSSE
HHHHCCCCCHHHCHH		24.6928796482
163PhosphorylationVTKAHHSSQEMSSEY
HHHCCCCCHHHCHHH		26.2924043423
167PhosphorylationHHSSQEMSSEYREYA
CCCCHHHCHHHHHHH		21.1828796482
168PhosphorylationHSSQEMSSEYREYAD
CCCHHHCHHHHHHHH		37.0228796482
170PhosphorylationSQEMSSEYREYADSF
CHHHCHHHHHHHHHH		15.6428796482
173PhosphorylationMSSEYREYADSFGKC
HCHHHHHHHHHHCCC		13.5028796482
176PhosphorylationEYREYADSFGKCPGG
HHHHHHHHHCCCCCC		27.9428796482
179UbiquitinationEYADSFGKCPGGRNP
HHHHHHCCCCCCCCC		34.93-
191PhosphorylationRNPWTGVSQFLQTSQ
CCCCCCHHHHHHHHH		19.2928857561
196PhosphorylationGVSQFLQTSQKIIQF
CHHHHHHHHHHHHHH		34.9628857561
197PhosphorylationVSQFLQTSQKIIQFA
HHHHHHHHHHHHHHH		19.2628857561
205PhosphorylationQKIIQFASGKEPQPG
HHHHHHHCCCCCCCC		52.25-
214PhosphorylationKEPQPGETVIYVAGA
CCCCCCCEEEEEEEC		20.3727251275
282PhosphorylationVLACRYVSEVVIGAP
HHHHHHHHHHHCCCC		18.7530622161
326UbiquitinationSDPYQEPKRRGIFRQ
CCCCCCCHHCCCCEE		54.71-
334UbiquitinationRRGIFRQIDSGSNLT
HCCCCEECCCCCCCC		3.8721906983
336PhosphorylationGIFRQIDSGSNLTTD
CCCEECCCCCCCCHH		45.8323403867
338PhosphorylationFRQIDSGSNLTTDLI
CEECCCCCCCCHHHH		32.3925693802
341PhosphorylationIDSGSNLTTDLIVQR
CCCCCCCCHHHHHHH		23.6329255136
342PhosphorylationDSGSNLTTDLIVQRI
CCCCCCCHHHHHHHH		31.7929255136
351PhosphorylationLIVQRIITNRLEYEA
HHHHHHHHHHHHHHH		16.3522210691
359PhosphorylationNRLEYEARNQKKEAK
HHHHHHHHHHHHHHH		33.8824719451
360PhosphorylationRLEYEARNQKKEAKE
HHHHHHHHHHHHHHH		66.1424719451
366UbiquitinationRNQKKEAKELAFLEA
HHHHHHHHHHHHHHH		55.1121906983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCY2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCY2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCY2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KDM8_HUMANKDM8physical
16189514
ATS10_HUMANADAMTS10physical
21900206
CRIP2_HUMANCRIP2physical
21900206
SETB1_HUMANSETDB1physical
21900206
DNM3B_HUMANDNMT3Bphysical
21900206
GDF9_HUMANGDF9physical
21900206
CAN2_HUMANCAPN2physical
22863883
DCPS_HUMANDCPSphysical
22863883
XPO1_HUMANXPO1physical
22863883
1433F_HUMANYWHAHphysical
22863883
SHIP2_HUMANINPPL1physical
26186194
SHIP2_HUMANINPPL1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00709Lamivudine
Regulatory Network of PCY2_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory