KDM8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM8_HUMAN
• UniProt AC: Q8N371
• Protein Name: JmjC domain-containing protein 5 {ECO:0000305}
• Gene Name: KDM8
• Organism: Homo sapiens (Human).
• Sequence Length: 416
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).
• Protein Description: Histone demethylase required for G2/M phase cell cycle progression. [PubMed: 20457893 Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator]
• Protein Sequence: MAGDTHCPAEPLAREGTLWEALRALLPHSKEDLKLDLGEKVERSVVTLLQRATELFYEGRRDECLQSSEVILDYSWEKLNTGTWQDVDKDWRRVYAIGCLLKALCLCQAPEDANTVAAALRVCDMGLLMGAAILGDILLKVAAILQTHLPGKRPARGSLPEQPCTKKARADHGLIPDVKLEKTVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQKWSLEYIQEIAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFDQIPELKQDISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRKYIRLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAPFLSCILSPGEILFIPVKYWHYVRALDLSFSVSFWWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	LGEKVERSVVTLLQR HHHHHHHHHHHHHHH	13.87	27251275
47	Phosphorylation	KVERSVVTLLQRATE HHHHHHHHHHHHHHH	21.42	27251275
53	Phosphorylation	VTLLQRATELFYEGR HHHHHHHHHHHHCCC	35.10	27251275
82	Phosphorylation	SWEKLNTGTWQDVDK CHHHCCCCCCCCCCC	24.71	27251275
91	Phosphorylation	WQDVDKDWRRVYAIG CCCCCCHHHHHHHHH	8.84	27251275
244	Phosphorylation	VEVGSRYTDEEWSQT EECCCCCCCHHHHHH	35.51	-
262	Phosphorylation	VNEFISKYIVNEPRD HHHHHHHHHCCCCCC	11.87	-
350	Phosphorylation	PQESGALYPHDTHLL CCCCCCCCCCCCCCC	9.66	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KDM8_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.