PDK3_HUMAN - dbPTM
PDK3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDK3_HUMAN
UniProt AC Q15120
Protein Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Gene Name PDK3
Organism Homo sapiens (Human).
Sequence Length 406
Subcellular Localization Mitochondrion matrix.
Protein Description Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species..
Protein Sequence MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationVPKQIERYSRFSPSP
CCHHHHHHCCCCCCC		7.4524961811
23PhosphorylationIERYSRFSPSPLSIK
HHHHCCCCCCCCCHH		24.2928060719
25PhosphorylationRYSRFSPSPLSIKQF
HHCCCCCCCCCHHHH		36.9624961811
30AcetylationSPSPLSIKQFLDFGR
CCCCCCHHHHHHCCC		31.4619826849
30UbiquitinationSPSPLSIKQFLDFGR
CCCCCCHHHHHHCCC		31.4621890473
30 (in isoform 2)Ubiquitination-31.46-
30UbiquitinationSPSPLSIKQFLDFGR
CCCCCCHHHHHHCCC		31.4621890473
43AcetylationGRDNACEKTSYMFLR
CCCCCCHHHHHHHHH		42.5325953088
125PhosphorylationRHNDVVPTMAQGVIE
CCCCCCCCHHHHHHH		17.3328857561
134AcetylationAQGVIEYKEKFGFDP
HHHHHHHHHHHCCCC		41.4525038526
169PhosphorylationRMLINQHTLLFGGDT
HHHHCCCEEECCCCC		18.52-
211PhosphorylationAKMLCEQYYLVAPEL
HHHHHHHHHEECCCC		4.04-
212PhosphorylationKMLCEQYYLVAPELE
HHHHHHHHEECCCCC		8.39-
236PhosphorylationDKPIQVVYVPSHLFH
CCCEEEEEEHHHHHH		14.0521406692
239PhosphorylationIQVVYVPSHLFHMLF
EEEEEEHHHHHHHHH		23.8421406692
252PhosphorylationLFELFKNSMRATVEL
HHHHHHHCHHHHHHH		15.3821406692
256PhosphorylationFKNSMRATVELYEDR
HHHCHHHHHHHHCHH		12.2621406692
260PhosphorylationMRATVELYEDRKEGY
HHHHHHHHCHHHCCC		11.4121406692
264AcetylationVELYEDRKEGYPAVK
HHHHCHHHCCCCHHH		68.7425038526
278SuccinylationKTLVTLGKEDLSIKI
HHHHCCCCCCCEEEH		51.6827452117
278SuccinylationKTLVTLGKEDLSIKI
HHHHCCCCCCCEEEH		51.68-
296AcetylationGGGVPLRKIDRLFNY
CCCCCHHHHHHHHHH		57.557462083
306PhosphorylationRLFNYMYSTAPRPSL
HHHHHHHCCCCCCCC		11.1028348404
307PhosphorylationLFNYMYSTAPRPSLE
HHHHHHCCCCCCCCC		24.1628348404
312PhosphorylationYSTAPRPSLEPTRAA
HCCCCCCCCCCCCCC		46.7928857561
316PhosphorylationPRPSLEPTRAAPLAG
CCCCCCCCCCCCCCC		24.4628857561
362PhosphorylationVIYLKALSSESFERL
EHHHHHCCCCHHHCC		36.6027251275
363PhosphorylationIYLKALSSESFERLP
HHHHHCCCCHHHCCC		37.8028857561
374SuccinylationERLPVFNKSAWRHYK
HCCCCCCHHHHHHCC		30.04-
381UbiquitinationKSAWRHYKTTPEADD
HHHHHHCCCCCCCCC		39.5329967540
393PhosphorylationADDWSNPSSEPRDAS
CCCCCCCCCCCCCHH		52.1328857561
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDK3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDK3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDK3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TCPZ_HUMANCCT6Aphysical
26496610
HLTF_HUMANHLTFphysical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
UTRO_HUMANUTRNphysical
26496610
TERA_HUMANVCPphysical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPQ_HUMANCCT8physical
26496610
ECD_HUMANECDphysical
26496610
TCPE_HUMANCCT5physical
26496610
ACAP2_HUMANACAP2physical
26496610
UBR7_HUMANUBR7physical
26496610
ODPAT_HUMANPDHA2physical
28514442
PDK1_HUMANPDK1physical
28514442
PDK2_HUMANPDK2physical
28514442
ODPX_HUMANPDHXphysical
28514442
ODPA_HUMANPDHA1physical
28514442
ODP2_HUMANDLATphysical
28514442
DNLZ_HUMANDNLZphysical
28514442
CH60_HUMANHSPD1physical
28514442
HDHD5_HUMANCECR5physical
28514442
IF1AX_HUMANEIF1AXphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300905Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDK3_HUMAN

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Related Literatures of Post-Translational Modification

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