HDHD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDHD5_HUMAN
• UniProt AC: Q9BXW7
• Protein Name: Haloacid dehalogenase-like hydrolase domain-containing 5 {ECO:0000312|HGNC:HGNC:1843}
• Gene Name: HDHD5 {ECO:0000312|HGNC:HGNC:1843}
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Protein Sequence: MAAWGCVAALGAARGLCWRAARAAAGLQGRPARRCYAVGPAQSPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLGGGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWALE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	ALGAARGLCWRAARA HHHHHHHHHHHHHHH		24816145
39	Acetylation	ARRCYAVGPAQSPPT CCCEEEECCCCCCCC		19608861
55	Ubiquitination	GFLLDIDGVLVRGHR EEEEEECCEEECCCC		24816145
69	Acetylation	RVIPAALKAFRRLVN CHHHHHHHHHHHHHH		19608861
69	Ubiquitination	RVIPAALKAFRRLVN CHHHHHHHHHHHHHH		19608861
69	Succinylation	RVIPAALKAFRRLVN CHHHHHHHHHHHHHH		23954790
69	Malonylation	RVIPAALKAFRRLVN CHHHHHHHHHHHHHH		26320211
74	Phosphorylation	ALKAFRRLVNSQGQL HHHHHHHHHHCCCCE		32142685
77	Phosphorylation	AFRRLVNSQGQLRVP HHHHHHHCCCCEECE		-
90	Ubiquitination	VPVVFVTNAGNILQH CEEEEEECCHHHHHC		22817900
91	Phosphorylation	PVVFVTNAGNILQHS EEEEEECCHHHHHCC		32142685
104	Phosphorylation	HSKAQELSALLGCEV CCHHHHHHHHHCCEE		32142685
109	Ubiquitination	ELSALLGCEVDADQV HHHHHHCCEECHHHE		24816145
118	Ubiquitination	VDADQVILSHSPMKL ECHHHEEECCCCCCH		22817900
119	Phosphorylation	DADQVILSHSPMKLF CHHHEEECCCCCCHH		27050516
121	Phosphorylation	DQVILSHSPMKLFSE HHEEECCCCCCHHHH		32142685
127	Phosphorylation	HSPMKLFSEYHEKRM CCCCCHHHHHHHHHC		30622161
129	Phosphorylation	PMKLFSEYHEKRMLV CCCHHHHHHHHHCCC		30622161
132	2-Hydroxyisobutyrylation	LFSEYHEKRMLVSGQ HHHHHHHHHCCCCCC		-
132	Succinylation	LFSEYHEKRMLVSGQ HHHHHHHHHCCCCCC		23954790
132	Ubiquitination	LFSEYHEKRMLVSGQ HHHHHHHHHCCCCCC		-
147	Ubiquitination	GPVMENAQGLGFRNV CHHHCCCCCCCCCCE		24816145
157	Ubiquitination	GFRNVVTVDELRMAF CCCCEEEHHHHHHHH		22817900
177	Ubiquitination	VDLERRLKTTPLPRN HCHHHHHCCCCCCCC		24816145
211	Ubiquitination	SLQLIMDVLLSNGSP HHHHHHHHHHHCCCC		22817900
249 (in isoform 2)	Ubiquitination	-		21906983
249	Ubiquitination	MAEAKMPRFGHGTFL EEECCCCCCCCHHHH		22817900
279	Ubiquitination	RYEGLMGKPSILTYQ CCCCCCCCCEEEHHH		22817900
279 (in isoform 1)	Ubiquitination	-		21906983
307	Ubiquitination	GWAAPIRKLYAVGDN CCCCCHHHHEEECCC		-
331	Ubiquitination	LFHQYLQKATHDGAP HHHHHHHHHCCCCCC		-
333	Phosphorylation	HQYLQKATHDGAPEL HHHHHHHCCCCCCCC		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDHD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDHD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDHD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDHD5_HUMAN	CECR5	physical	27499296
TIM44_HUMAN	TIMM44	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
PDK3_HUMAN	PDK3	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MSRB2_HUMAN	MSRB2	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.