PP2BC_HUMAN - dbPTM
PP2BC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2BC_HUMAN
UniProt AC P48454
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Gene Name PPP3CC
Organism Homo sapiens (Human).
Sequence Length 512
Subcellular Localization
Protein Description Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32..
Protein Sequence MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16UbiquitinationSTTDRVIKAVPFPPT
CCCCCCHHCCCCCCC		40.2427667366
29UbiquitinationPTQRLTFKEVFENGK
CCCCEEHHHHHHCCC		47.9729967540
36UbiquitinationKEVFENGKPKVDVLK
HHHHHCCCCCHHHHH		53.93-
43UbiquitinationKPKVDVLKNHLVKEG
CCCHHHHHHHHHCCC		42.0124816145
48UbiquitinationVLKNHLVKEGRLEEE
HHHHHHHCCCCCCHH		61.8929967540
59UbiquitinationLEEEVALKIINDGAA
CCHHHHHHHHHCHHH		31.6329967540
103PhosphorylationKLFEVGGSPSNTRYL
HHHCCCCCCCCCEEE		21.1625850435
105PhosphorylationFEVGGSPSNTRYLFL
HCCCCCCCCCEEEEE		53.1625850435
107PhosphorylationVGGSPSNTRYLFLGD
CCCCCCCCEEEEECC		25.6525850435
115PhosphorylationRYLFLGDYVDRGYFS
EEEEECCCCCCCCCH		11.49-
159UbiquitinationLTDYFTFKQECRIKY
CCCCEEECCHHHCCC		41.9721906983
241UbiquitinationDYGNEKTLEHYTHNT
CCCCCCCHHHHCCCC		5.9022817900
246UbiquitinationKTLEHYTHNTVRGCS
CCHHHHCCCCCCCCC		22.3127667366
314UbiquitinationYLDVYNNKAAVLKYE
EEHHCCCCEEEEEEE		33.8022817900
319UbiquitinationNNKAAVLKYENNVMN
CCCEEEEEEECCEEC		43.8721906983
319 (in isoform 1)Ubiquitination-43.8721890473
319UbiquitinationNNKAAVLKYENNVMN
CCCEEEEEEECCEEC		43.8721890473
319 (in isoform 2)Ubiquitination-43.8721890473
345UbiquitinationWLPNFMDVFTWSLPF
CCCCHHHHHHCCCCC		2.8622817900
358PhosphorylationPFVGEKVTEMLVNVL
CCCCHHHHHHHHHHH		27.0925693802
369PhosphorylationVNVLNICSDDELISD
HHHHHHCCCCCCCCC		44.2828102081
375PhosphorylationCSDDELISDDEAEGS
CCCCCCCCCCCCCCC		52.1925693802
382PhosphorylationSDDEAEGSTTVRKEI
CCCCCCCCHHHHHHH		16.6525693802
383PhosphorylationDDEAEGSTTVRKEII
CCCCCCCHHHHHHHH		39.9225693802
384PhosphorylationDEAEGSTTVRKEIIR
CCCCCCHHHHHHHHH		21.7325693802
405PhosphorylationGKMARVFSILRQESE
HHHHHHHHHHHHCCC		20.18-
418UbiquitinationSESVLTLKGLTPTGT
CCCEEEECCCCCCCC		46.7922817900
425PhosphorylationKGLTPTGTLPLGVLS
CCCCCCCCCEEEEEC		27.9027251275
427UbiquitinationLTPTGTLPLGVLSGG
CCCCCCCEEEEECCC		27.2322817900
434PhosphorylationPLGVLSGGKQTIETA
EEEEECCCEEEEEEE		18.6027251275
456PhosphorylationREAIRGFSLQHKIRS
HHHHHCCCHHHHHHC		29.91-
460UbiquitinationRGFSLQHKIRSFEEA
HCCCHHHHHHCHHHH		27.1829967540
463PhosphorylationSLQHKIRSFEEARGL
CHHHHHHCHHHHCCH		40.2528857561
469UbiquitinationRSFEEARGLDRINER
HCHHHHCCHHHHHHC		38.6929967540
471UbiquitinationFEEARGLDRINERMP
HHHHCCHHHHHHCCC		52.8429967540
481UbiquitinationNERMPPRKDSIHAGG
HHCCCCCCCCCCCCC		62.7029967540
483PhosphorylationRMPPRKDSIHAGGPM
CCCCCCCCCCCCCCC		21.2223401153
490UbiquitinationSIHAGGPMKSVTSAH
CCCCCCCCCCCHHCC		5.9729967540
492PhosphorylationHAGGPMKSVTSAHSH
CCCCCCCCCHHCCCC		25.1127251275
495PhosphorylationGPMKSVTSAHSHAAH
CCCCCCHHCCCCCCC		23.1023532336
504PhosphorylationHSHAAHRSDQGKKAH
CCCCCCCCCCCCCCC		25.1523532336
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2BC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2BC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2BC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
SDC2_HUMANSDC2physical
21988832
THAP7_HUMANTHAP7physical
21988832
PP2BB_HUMANPPP3CBphysical
26186194
SIK3_HUMANSIK3physical
26186194
NFAC1_HUMANNFATC1physical
26186194
CANB1_HUMANPPP3R1physical
26186194
RCAN1_HUMANRCAN1physical
26186194
NFAC4_HUMANNFATC4physical
26186194
ARI3B_HUMANARID3Bphysical
26186194
GSK3B_HUMANGSK3Bphysical
26186194
GSK3A_HUMANGSK3Aphysical
26186194
LRC41_HUMANLRRC41physical
26186194
ARMT1_HUMANC6orf211physical
26344197
LBH_HUMANLBHphysical
27880917
CANB1_HUMANPPP3R1physical
27880917
RCAN1_HUMANRCAN1physical
27880917
RCAN3_HUMANRCAN3physical
27880917
NFAC1_HUMANNFATC1physical
28514442
SIK3_HUMANSIK3physical
28514442
NFAC4_HUMANNFATC4physical
28514442
CANB1_HUMANPPP3R1physical
28514442
GSK3A_HUMANGSK3Aphysical
28514442
PP2BB_HUMANPPP3CBphysical
28514442
LRC41_HUMANLRRC41physical
28514442
GSK3B_HUMANGSK3Bphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2BC_HUMAN

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Related Literatures of Post-Translational Modification

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