LBH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LBH_HUMAN
• UniProt AC: Q53QV2
• Protein Name: Protein LBH {ECO:0000305}
• Gene Name: LBH {ECO:0000312|HGNC:HGNC:29532}
• Organism: Homo sapiens (Human).
• Sequence Length: 105
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway..
• Protein Sequence: MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQIFPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETAKENKEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSIYFPIHCPD ----CCEEECCCCHH	8.94	27642862
12	Phosphorylation	FPIHCPDYLRSAKMT ECCCCHHHHHHCCCH	6.80	30301811
15	Phosphorylation	HCPDYLRSAKMTEVM CCHHHHHHCCCHHHH	29.64	30301811
19	Phosphorylation	YLRSAKMTEVMMNTQ HHHHCCCHHHHHCCC	25.40	22199227
25	Phosphorylation	MTEVMMNTQPMEEIG CHHHHHCCCCHHHCC	19.02	22617229
34	Phosphorylation	PMEEIGLSPRKDGLS CHHHCCCCCCCCCCC	19.90	22199227
41	Phosphorylation	SPRKDGLSYQIFPDP CCCCCCCCEEECCCH	22.11	26074081
42	Phosphorylation	PRKDGLSYQIFPDPS CCCCCCCEEECCCHH	15.63	26074081
63	Phosphorylation	KLKDRLPSIVVEPTE HHHHCCCCEEEECCC	32.38	19664994
69	Phosphorylation	PSIVVEPTEGEVESG CCEEEECCCCCCCCC	43.02	16094384
75	Phosphorylation	PTEGEVESGELRWPP CCCCCCCCCCCCCCC	42.62	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LBH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LBH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LBH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRYAB_HUMAN	CRYAB	physical	20587334
PROX1_HUMAN	PROX1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.
PubMed: 17081983

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69, AND MASSSPECTROMETRY.
PubMed: 16094384