PROX1_HUMAN - dbPTM
PROX1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PROX1_HUMAN
UniProt AC Q92786
Protein Name Prospero homeobox protein 1
Gene Name PROX1
Organism Homo sapiens (Human).
Sequence Length 737
Subcellular Localization Nucleus . RORG promotes its nuclear localization.
Protein Description Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3..
Protein Sequence MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationKLLKRANSYEDAMMP
HHHHHCCCCCHHCCC		28.9922617229
80PhosphorylationLLKRANSYEDAMMPF
HHHHCCCCCHHCCCC		20.0326657352
91PhosphorylationMMPFPGATIISQLLK
CCCCCHHHHHHHHHH		25.4319835603
94PhosphorylationFPGATIISQLLKNNM
CCHHHHHHHHHHHCC		15.7819835603
136PhosphorylationCSNSSRDSPPECLSP
CCCCCCCCCHHHCCC		41.0427732954
142PhosphorylationDSPPECLSPFGRPTM
CCCHHHCCCCCCCCC		29.8227732954
177PhosphorylationENIIRGMSHSPSVAL
HHHHHCCCCCCCCCC		24.5230266825
179PhosphorylationIIRGMSHSPSVALRG
HHHCCCCCCCCCCCC		16.1530266825
181PhosphorylationRGMSHSPSVALRGNE
HCCCCCCCCCCCCCC		24.0427987026
197PhosphorylationEREMAPQSVSPRESY
CCCCCCCCCCHHHHH		24.4129255136
199PhosphorylationEMAPQSVSPRESYRE
CCCCCCCCHHHHHHH		24.4029255136
203PhosphorylationQSVSPRESYRENKRK
CCCCHHHHHHHHHHH		30.6727732954
204PhosphorylationSVSPRESYRENKRKQ
CCCHHHHHHHHHHHH		19.7327732954
220PhosphorylationLPQQQQQSFQQLVSA
CCHHHHHHHHHHHHH		22.2322912867
226PhosphorylationQSFQQLVSARKEQKR
HHHHHHHHHHHHHHH		30.8327732954
258PhosphorylationRQLQEKFYQIYDSTD
HHHHHHHHHHHHCCC		12.6927732954
261PhosphorylationQEKFYQIYDSTDSEN
HHHHHHHHHCCCCCC		6.5827732954
263PhosphorylationKFYQIYDSTDSENDE
HHHHHHHCCCCCCCC		19.6927732954
264PhosphorylationFYQIYDSTDSENDED
HHHHHHCCCCCCCCC		40.4227732954
266PhosphorylationQIYDSTDSENDEDGN
HHHHCCCCCCCCCCC		38.0927732954
275PhosphorylationNDEDGNLSEDSMRSE
CCCCCCCCHHHHHHH		43.2727732954
278PhosphorylationDGNLSEDSMRSEILD
CCCCCHHHHHHHHHH		16.4327732954
281PhosphorylationLSEDSMRSEILDARA
CCHHHHHHHHHHHHH		21.9827499020
291PhosphorylationLDARAQDSVGRSDNE
HHHHHHHCCCCCCCC		17.8722617229
295PhosphorylationAQDSVGRSDNEMCEL
HHHCCCCCCCCCCCC		38.5722617229
324SumoylationEQEMAENKPKREGNN
HHHHHHCCCCCCCCC		43.3425755297
340PhosphorylationERDHGPNSLQPEGKH
CCCCCCCCCCHHHHH		31.3629116813
353SumoylationKHLAETLKQELNTAM
HHHHHHHHHHHHHHH		49.50-
353SumoylationKHLAETLKQELNTAM
HHHHHHHHHHHHHHH		49.50-
361PhosphorylationQELNTAMSQVVDTVV
HHHHHHHHHHHHHHH		19.8427050516
372PhosphorylationDTVVKVFSAKPSRQV
HHHHHHHCCCCCCCC		38.07-
447PhosphorylationPLVVRKNSSDQSASG
CEEEECCCCCCCCCC		38.0230177828
448PhosphorylationLVVRKNSSDQSASGP
EEEECCCCCCCCCCC		49.4130177828
451PhosphorylationRKNSSDQSASGPAAG
ECCCCCCCCCCCCCC		29.4130177828
453PhosphorylationNSSDQSASGPAAGGH
CCCCCCCCCCCCCCC		51.0229116813
467PhosphorylationHHQPLHQSPLSATTG
CCCCCCCCCCCCCCC		19.6329116813
470PhosphorylationPLHQSPLSATTGFTT
CCCCCCCCCCCCCCC		27.2730177828
472PhosphorylationHQSPLSATTGFTTST
CCCCCCCCCCCCCCC		24.8730177828
473PhosphorylationQSPLSATTGFTTSTF
CCCCCCCCCCCCCCC		29.9830177828
476PhosphorylationLSATTGFTTSTFRHP
CCCCCCCCCCCCCCC		22.6023312004
477PhosphorylationSATTGFTTSTFRHPF
CCCCCCCCCCCCCCC		24.4123312004
478PhosphorylationATTGFTTSTFRHPFP
CCCCCCCCCCCCCCC		23.6123312004
479PhosphorylationTTGFTTSTFRHPFPL
CCCCCCCCCCCCCCC		23.6923312004
495PhosphorylationLMAYPFQSPLGAPSG
EEEECCCCCCCCCCC		23.5927732954
501PhosphorylationQSPLGAPSGSFSGKD
CCCCCCCCCCCCCCC		46.6827732954
511PhosphorylationFSGKDRASPESLDLT
CCCCCCCCHHHCCCC		30.0530266825
514PhosphorylationKDRASPESLDLTRDT
CCCCCHHHCCCCCCC		30.4830266825
518PhosphorylationSPESLDLTRDTTSLR
CHHHCCCCCCCHHHH		26.6027251275
521PhosphorylationSLDLTRDTTSLRTKM
HCCCCCCCHHHHHHH		18.2627251275
522PhosphorylationLDLTRDTTSLRTKMS
CCCCCCCHHHHHHHH		30.0127251275
523PhosphorylationDLTRDTTSLRTKMSS
CCCCCCHHHHHHHHH		20.2527251275
529PhosphorylationTSLRTKMSSHHLSHH
HHHHHHHHHCCCCCC		28.2423312004
530PhosphorylationSLRTKMSSHHLSHHP
HHHHHHHHCCCCCCC		16.0723312004
534PhosphorylationKMSSHHLSHHPCSPA
HHHHCCCCCCCCCCC		18.5223312004
539PhosphorylationHLSHHPCSPAHPPST
CCCCCCCCCCCCCCC		29.5829116813
545PhosphorylationCSPAHPPSTAEGLSL
CCCCCCCCCHHCCCH		44.7123312004
546PhosphorylationSPAHPPSTAEGLSLS
CCCCCCCCHHCCCHH		34.2123312004
553PhosphorylationTAEGLSLSLIKSECG
CHHCCCHHHHHHHCC		25.3624719451
556SumoylationGLSLSLIKSECGDLQ
CCCHHHHHHHCCCCC		45.56-
556SumoylationGLSLSLIKSECGDLQ
CCCHHHHHHHCCCCC		45.56-
557PhosphorylationLSLSLIKSECGDLQD
CCHHHHHHHCCCCCC		31.0025755297
566PhosphorylationCGDLQDMSEISPYSG
CCCCCCHHHCCCCCC		39.8229116813
569PhosphorylationLQDMSEISPYSGSAM
CCCHHHCCCCCCCHH		17.4629116813
648PhosphorylationQAINDGVTSTEELSI
HHHHCCCCCHHHHHC		35.1522210691
649PhosphorylationAINDGVTSTEELSIT
HHHCCCCCHHHHHCC		31.2622210691
656PhosphorylationSTEELSITRDCELYR
CHHHHHCCCCHHHHH		19.6522210691
707AcetylationKDVDPSWKKAIYKVI
CCCCHHHHHHHHHHH		36.3412656601
708AcetylationDVDPSWKKAIYKVIC
CCCHHHHHHHHHHHH		33.4812656609
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PROX1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PROX1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PROX1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EP300_HUMANEP300physical
11943779
ZBTB3_HUMANZBTB3physical
20211142
HDAC3_HUMANHDAC3physical
18948102
SMAD3_HUMANSMAD3physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PROX1_HUMAN

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Related Literatures of Post-Translational Modification

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