dbPTM

ZBTB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZBTB3_HUMAN
UniProt AC	Q9H5J0
Protein Name	Zinc finger and BTB domain-containing protein 3
Gene Name	ZBTB3
Organism	Homo sapiens (Human).
Sequence Length	574
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MLREFSKWGVEASPGKAWERKRSLLRGAVGRYRGATGGDLFWAPFPSWGTMEFPEHSQQLLQSLREQRSQGFLCDCTVMVGSTQFLAHRAVLASCSPFFQLFYKERELDKRDLVCIHNEIVTAPAFGLLLDFMYAGQLTLRGDTPVEDVLAAASYLHMNDIVKVCKRRLQARALAEADSTKKEEETNSQLPSLEFLSSTSRGTQPSLASAETSGHWGKGEWKGSAAPSPTVRPPDEPPMSSGADTTQPGMEVDAPHLRAPHPPVADVSLASPSSSTETIPTNYFSSGISAVSLEPLPSLDVGPESLRVVEPKDPGGPLQGFYPPASAPTSAPAPVSAPVPSQAPAPAEAELVQVKVEAIVISDEETDVSDEQPQGPERAFPSGGAVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPHLPYHLLPGAGQYHRGLVTSPLPAPASLHEPLYLSSEYEAAPGSFGVFTEDVPTCKTCGKTFSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEVGPLLGVQPLPGSPTADRQSSSGGGPPKDFVLAPKTNI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SKWGVEASPGKAWER HHCCCCCCCCHHHHH	22.22	25159151
63	Phosphorylation	HSQQLLQSLREQRSQ HHHHHHHHHHHHHHC	29.39	-
181	Sumoylation	LAEADSTKKEEETNS HHHHHCCHHHHHHHC	63.24	-
181	Sumoylation	LAEADSTKKEEETNS HHHHHCCHHHHHHHC	63.24	28112733
182	Sumoylation	AEADSTKKEEETNSQ HHHHCCHHHHHHHCC	71.14	28112733
186	Phosphorylation	STKKEEETNSQLPSL CCHHHHHHHCCCCCH	43.37	-
209	Phosphorylation	GTQPSLASAETSGHW CCCCCCCCCCCCCCC	31.75	27251275
212	Phosphorylation	PSLASAETSGHWGKG CCCCCCCCCCCCCCC	39.46	25627689
213	Phosphorylation	SLASAETSGHWGKGE CCCCCCCCCCCCCCC	21.84	25159151
228	Phosphorylation	WKGSAAPSPTVRPPD CCCCCCCCCCCCCCC	28.60	28348404
230	Phosphorylation	GSAAPSPTVRPPDEP CCCCCCCCCCCCCCC	33.22	24719451
268	Phosphorylation	HPPVADVSLASPSSS CCCCCCCEECCCCCC	20.83	26074081
271	Phosphorylation	VADVSLASPSSSTET CCCCEECCCCCCCCC	30.52	26074081
273	Phosphorylation	DVSLASPSSSTETIP CCEECCCCCCCCCCC	34.13	26074081
274	Phosphorylation	VSLASPSSSTETIPT CEECCCCCCCCCCCC	44.67	26074081
275	Phosphorylation	SLASPSSSTETIPTN EECCCCCCCCCCCCC	34.30	26074081
276	Phosphorylation	LASPSSSTETIPTNY ECCCCCCCCCCCCCC	38.81	26074081
278	Phosphorylation	SPSSSTETIPTNYFS CCCCCCCCCCCCCCC	32.14	28348404
362	Phosphorylation	KVEAIVISDEETDVS EEEEEEECCCCCCCC	28.24	29255136
366	Phosphorylation	IVISDEETDVSDEQP EEECCCCCCCCCCCC	39.39	29255136
369	Phosphorylation	SDEETDVSDEQPQGP CCCCCCCCCCCCCCC	37.93	30108239
438	Phosphorylation	QYHRGLVTSPLPAPA CCCCCCCCCCCCCCC	29.66	25159151
439	Phosphorylation	YHRGLVTSPLPAPAS CCCCCCCCCCCCCCC	19.57	28387310
446	Phosphorylation	SPLPAPASLHEPLYL CCCCCCCCCCCCEEE	29.24	28387310
482	Phosphorylation	KTCGKTFSCSYTLRR CCCCCEEECCEEEEC	13.85	28555341
486	Phosphorylation	KTFSCSYTLRRHATV CEEECCEEEECCCEE	9.48	24719451
508	Phosphorylation	ECRYCLRSYTQSGDL CHHHHHHHHCCCHHH	21.42	20873877
509	Phosphorylation	CRYCLRSYTQSGDLY HHHHHHHHCCCHHHH	11.45	20873877
510	Phosphorylation	RYCLRSYTQSGDLYR HHHHHHHCCCHHHHH	19.94	20873877
512	Phosphorylation	CLRSYTQSGDLYRHI HHHHHCCCHHHHHHH	26.86	20873877
516	Phosphorylation	YTQSGDLYRHIRKAH HCCCHHHHHHHHHHH	12.60	-
531	Phosphorylation	NEDLAKRSKPDPEVG HHHHHHHCCCCCCCC	48.08	23927012
532	Sumoylation	EDLAKRSKPDPEVGP HHHHHHCCCCCCCCC	58.43	28112733
549	Phosphorylation	GVQPLPGSPTADRQS CCCCCCCCCCCCCCC	19.69	23401153
551	Phosphorylation	QPLPGSPTADRQSSS CCCCCCCCCCCCCCC	42.77	30266825
556	Phosphorylation	SPTADRQSSSGGGPP CCCCCCCCCCCCCCC	27.62	26074081
557	Phosphorylation	PTADRQSSSGGGPPK CCCCCCCCCCCCCCH	25.35	26074081
558	Phosphorylation	TADRQSSSGGGPPKD CCCCCCCCCCCCCHH	46.86	26074081
572	Phosphorylation	DFVLAPKTNI----- HHEECCCCCC-----	36.77	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:31911863

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZBTB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZBTB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ZN556_HUMAN	ZNF556	physical	20211142

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZBTB3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, AND MASSSPECTROMETRY.	19690332 [Abstract]