ZN556_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN556_HUMAN
• UniProt AC: Q9HAH1
• Protein Name: Zinc finger protein 556
• Gene Name: ZNF556
• Organism: Homo sapiens (Human).
• Sequence Length: 456
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MDTVVFEDVVVDFTLEEWALLNPAQRKLYRDVMLETFKHLASVDNEAQLKASGSISQQDTSGEKLSLKQKIEKFTRKNIWASLLGKNWEEHSVKDKHNTKERHLSRNPRVERPCKSSKGNKRGRTFRKTRNCNRHLRKNCCTSVRRYECSQCGKLFTHSSSLIRHKRAHSGQKLYKCKECGKAFSRPSYLQTHEKTHSGEKPYACQSCGKTFLRSHSLTEHVRTHTGEKPYECGQCGKGFSCPKSFRAHVMMHAGGRPYECKHCGKAFRCQKSFRVHMIMHAGGRPYECKQCGKAYCWATSFQRHVRIHNGEKPYKCGKCGKAFGWPSSLHKHARTHAKKKPVSGGSVGKSSARPRPSTDVKSQTREKVYKCETCGKTYGWSSSLHKHERKHTGEKPVNAASVGKPSGGLCSSKNVRTQIGQKPSKCEKCGKAFSCPKAFQGHVRSHTGKKSCTSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Phosphorylation	GKNWEEHSVKDKHNT CCCHHHHCCCCCCCC	33.86	27174698
99	Phosphorylation	SVKDKHNTKERHLSR CCCCCCCCHHHHHHC	33.72	27174698
157	Phosphorylation	SQCGKLFTHSSSLIR CHHCCCEECCHHHHH	31.14	-
157	O-linked_Glycosylation	SQCGKLFTHSSSLIR CHHCCCEECCHHHHH	31.14	OGP
160	Phosphorylation	GKLFTHSSSLIRHKR CCCEECCHHHHHHCC	22.89	24719451
161	Phosphorylation	KLFTHSSSLIRHKRA CCEECCHHHHHHCCC	30.72	24719451
173	Acetylation	KRAHSGQKLYKCKEC CCCCCCCCEEECCHH	58.26	7971997
178	Acetylation	GQKLYKCKECGKAFS CCCEEECCHHHCCCC	52.46	7972005
188	Phosphorylation	GKAFSRPSYLQTHEK HCCCCCCHHHHCCCC	37.05	28555341
215	Phosphorylation	CGKTFLRSHSLTEHV CCCCHHHHCCCHHHH	21.41	29449344
217	Phosphorylation	KTFLRSHSLTEHVRT CCHHHHCCCHHHHHH	37.93	29116813
219	Phosphorylation	FLRSHSLTEHVRTHT HHHHCCCHHHHHHHC	27.36	29449344
224	Phosphorylation	SLTEHVRTHTGEKPY CCHHHHHHHCCCCCC	23.77	-
226	Phosphorylation	TEHVRTHTGEKPYEC HHHHHHHCCCCCCCC	46.56	21857030
290	Sumoylation	GGRPYECKQCGKAYC CCCCEECCCCCCEEE	36.36	-
290	Sumoylation	GGRPYECKQCGKAYC CCCCEECCCCCCEEE	36.36	-
300	Phosphorylation	GKAYCWATSFQRHVR CCEEEEEEECCCCEE	12.94	28348404
301	Phosphorylation	KAYCWATSFQRHVRI CEEEEEEECCCCEEC	16.19	28348404
351	Phosphorylation	SGGSVGKSSARPRPS CCCCCCCCCCCCCCC	24.25	24260401
352	Phosphorylation	GGSVGKSSARPRPST CCCCCCCCCCCCCCC	31.61	24260401
393	Phosphorylation	HKHERKHTGEKPVNA CCCCCCCCCCCCCCH	50.50	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN556_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN556_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN556_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TYW2_HUMAN	TRMT12	physical	28514442
ANKS3_HUMAN	ANKS3	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
TRI39_HUMAN	TRIM39	physical	28514442
LRP4_HUMAN	LRP4	physical	28514442
RT24_HUMAN	MRPS24	physical	28514442
ASAH1_HUMAN	ASAH1	physical	28514442
MTHR_HUMAN	MTHFR	physical	28514442
NEK7_HUMAN	NEK7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.