TYW2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYW2_HUMAN
• UniProt AC: Q53H54
• Protein Name: tRNA wybutosine-synthesizing protein 2 homolog
• Gene Name: TRMT12
• Organism: Homo sapiens (Human).
• Sequence Length: 448
• Protein Description: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86..
• Protein Sequence: MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	DTQHRVEKMPDGSVA CCCCHHHCCCCCCCC	53.53	29967540
82	Phosphorylation	RNRVAPGSPCMLTQL HHCCCCCCCCCHHCC	17.54	27050516
96	Ubiquitination	LPDPVPSKRAQGCSP CCCCCCCCCCCCCCH	45.76	-
180	O-linked_Glycosylation	LAKRGRVSPDGTRTP HHHCCCCCCCCCCCC	18.86	30379171
298	Ubiquitination	FGDNRKLKLSNIADR ECCCCEEEECCCCCH	53.56	-
354	Ubiquitination	LQALGVSKVEKEHWL CEECCCCCCCCCCEE	52.59	29967540
357	Ubiquitination	LGVSKVEKEHWLYPQ CCCCCCCCCCEECCE	58.84	29967540
367	O-linked_Glycosylation	WLYPQQITTNQWKNG EECCEECCCCCCCCC	18.50	30379171
368	O-linked_Glycosylation	LYPQQITTNQWKNGA ECCEECCCCCCCCCC	27.35	30379171
388	Phosphorylation	GKMLSPATKPEWQRW CCCCCCCCCHHHHHH	50.98	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYW2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYW2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYW2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	25416956
HSP7C_HUMAN	HSPA8	physical	28514442
HSP74_HUMAN	HSPA4	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.