dbPTM

THAP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THAP7_HUMAN
UniProt AC	Q9BT49
Protein Name	THAP domain-containing protein 7
Gene Name	THAP7
Organism	Homo sapiens (Human).
Sequence Length	309
Subcellular Localization	Nucleus. Chromosome.
Protein Description	Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors..
Protein Sequence	MPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDPASEYIYFCSKHFEEDCFELVGISGYHRLKEGAVPTIFESFSKLRRTTKTKGHSYPPGPAEVSRLRRCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLPASPAGRLEPGLSSPFSDLLGPLGAQADEAGCSAQPSPERQPSPLEPRPVSPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKEHVQDFAMQLSSSMA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	LKEGAVPTIFESFSK HHCCCCCHHHHHHHH	31.53	-
95	Phosphorylation	AVPTIFESFSKLRRT CCCHHHHHHHHHHCC	24.87	24719451
97	Phosphorylation	PTIFESFSKLRRTTK CHHHHHHHHHHCCCC	39.81	-
146	Phosphorylation	PPPPADVTCFPVEEA CCCCCCCEEEECHHC	14.69	26074081
154	Phosphorylation	CFPVEEASAPATLPA EEECHHCCCCCCCCC	37.76	26074081
158	Phosphorylation	EEASAPATLPASPAG HHCCCCCCCCCCCCC	32.01	26074081
162	Phosphorylation	APATLPASPAGRLEP CCCCCCCCCCCCCCC	17.22	29255136
192	Phosphorylation	QADEAGCSAQPSPER CCCCCCCCCCCCCCC	29.08	28348404
196	Phosphorylation	AGCSAQPSPERQPSP CCCCCCCCCCCCCCC	27.58	28348404
202	Phosphorylation	PSPERQPSPLEPRPV CCCCCCCCCCCCCCC	33.50	23312004
210	Phosphorylation	PLEPRPVSPSAYMLR CCCCCCCCCCCEEEE	18.80	28348404
212	Phosphorylation	EPRPVSPSAYMLRLP CCCCCCCCCEEEECC	25.24	23312004
253	Ubiquitination	AALDALDKAQRQLQA HHHHHHHHHHHHHHH	47.47	29967540
274	Acetylation	RLRLRLTKLQQERAR HHHHHHHHHHHHHHH	49.22	69507

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THAP7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THAP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THAP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LURA1_HUMAN	LURAP1	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
TAF1B_HUMAN	TAF1B	physical	16195249
H31_HUMAN	HIST1H3A	physical	15561719
HDAC3_HUMAN	HDAC3	physical	15561719
HINFP_HUMAN	HINFP	physical	17577209
A4_HUMAN	APP	physical	21832049
THAP7_HUMAN	THAP7	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
RL26L_HUMAN	RPL26L1	physical	26186194
RL26_HUMAN	RPL26	physical	26186194
NIP7_HUMAN	NIP7	physical	26186194
ASPM_HUMAN	ASPM	physical	26186194
DDX24_HUMAN	DDX24	physical	26186194
ZN512_HUMAN	ZNF512	physical	26186194
RL7_HUMAN	RPL7	physical	26186194
CEBPZ_HUMAN	CEBPZ	physical	26186194
EXOC1_HUMAN	EXOC1	physical	26186194
RS3A_HUMAN	RPS3A	physical	26186194
NOP56_HUMAN	NOP56	physical	26186194
RL13_HUMAN	RPL13	physical	26186194
CG050_HUMAN	C7orf50	physical	26186194
EBP2_HUMAN	EBNA1BP2	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
RS27A_HUMAN	RPS27A	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
RL32_HUMAN	RPL32	physical	26186194
RL13A_HUMAN	RPL13A	physical	26186194
RL18A_HUMAN	RPL18A	physical	26186194
NLE1_HUMAN	NLE1	physical	26186194
ASH1L_HUMAN	ASH1L	physical	26186194
TRI26_HUMAN	TRIM26	physical	26186194
RS27A_HUMAN	RPS27A	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
EXOC1_HUMAN	EXOC1	physical	28514442
NLE1_HUMAN	NLE1	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
ASH1L_HUMAN	ASH1L	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THAP7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND MASSSPECTROMETRY.	18691976 [Abstract]