TRI26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI26_HUMAN
• UniProt AC: Q12899
• Protein Name: Tripartite motif-containing protein 26
• Gene Name: TRIM26
• Organism: Homo sapiens (Human).
• Sequence Length: 539
• Subcellular Localization: Cytoplasm . Nucleus . Viral infection mediates TRIM26 nuclear translocation.
• Protein Description: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1..
• Protein Sequence: MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSLYKSAYLHPQQFDCEPGVLGSKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEVLESCMVGVARDSVKRKGDLSLRPEDGVWALRLSSSGIWANTSPEAELFPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFTRRLVPFLWLKWPGTRLLLRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ATSAPLRSLEEEVTC CCCCCCCCCCHHHHH	48.06	27251275
47	Phosphorylation	TTDVRPISGSRPVCP CCCCEECCCCCCCCC	33.14	25159151
49	Phosphorylation	DVRPISGSRPVCPLC CCEECCCCCCCCCCC	26.98	25159151
73	Phosphorylation	RPVWQLASLVENIER CHHHHHHHHHHHHHH	41.35	27251275
85	Ubiquitination	IERLKVDKGRQPGEV HHHHCCCCCCCCCCC	60.01	-
140	Ubiquitination	HTAVLMEKAAQPHRE CHHHHHHHCCHHHHH	34.75	-
148	Acetylation	AAQPHREKILNHLST CCHHHHHHHHHHHHH	53.07	25953088
148	Ubiquitination	AAQPHREKILNHLST CCHHHHHHHHHHHHH	53.07	-
154	Phosphorylation	EKILNHLSTLRRDRD HHHHHHHHHHHHCHH	20.18	27174698
155	Phosphorylation	KILNHLSTLRRDRDK HHHHHHHHHHHCHHH	30.55	27174698
162	Ubiquitination	TLRRDRDKIQGFQAK HHHHCHHHHHCCHHH	37.51	-
169	Ubiquitination	KIQGFQAKGEADILA HHHCCHHHCHHHHHH	46.64	-
179	Ubiquitination	ADILAALKKLQDQRQ HHHHHHHHHHHHHHH	46.87	21890473
179	Ubiquitination	ADILAALKKLQDQRQ HHHHHHHHHHHHHHH	46.87	21890473
180	Ubiquitination	DILAALKKLQDQRQY HHHHHHHHHHHHHHH	52.83	-
223	Ubiquitination	ELTEGREKFKSRGVG HHHHHHHHHHHCCHH	57.65	-
245	Ubiquitination	VISELEGKAQQPAAE HHHHHCCCCCCHHHH	33.38	21890473
273	Ubiquitination	RKKFWVGKPIARVVK HHHCCCCCCHHHHHH	24.51	-
289	Ubiquitination	KTGEFSDKLLSLQRG HHCCCHHHHHHHHHH	50.56	-
289	Acetylation	KTGEFSDKLLSLQRG HHCCCHHHHHHHHHH	50.56	25953088
292	Phosphorylation	EFSDKLLSLQRGLRE CCHHHHHHHHHHHHH	32.65	24719451
303	Acetylation	GLREFQGKLLRDLEY HHHHHHHHHHHCCEE	33.30	20167786
310	Phosphorylation	KLLRDLEYKTVSVTL HHHHCCEEEEEEEEE	21.18	26270265
312	Phosphorylation	LRDLEYKTVSVTLDP HHCCEEEEEEEEECC	19.67	26270265
314	Phosphorylation	DLEYKTVSVTLDPQS CCEEEEEEEEECCCC	18.02	26270265
316	Phosphorylation	EYKTVSVTLDPQSAS EEEEEEEEECCCCCC	20.24	26270265
337	Phosphorylation	EDWKCVTYTSLYKSA CCCEEEEHHHHHHHH	3.64	29116813
341	Phosphorylation	CVTYTSLYKSAYLHP EEEHHHHHHHHCCCH	11.58	29116813
342	Ubiquitination	VTYTSLYKSAYLHPQ EEHHHHHHHHCCCHH	33.62	-
345	Phosphorylation	TSLYKSAYLHPQQFD HHHHHHHCCCHHHCC	16.78	27642862
361	Ubiquitination	EPGVLGSKGFTWGKV CCCCCCCCCCCCEEE	57.13	-
367	Ubiquitination	SKGFTWGKVYWEVEV CCCCCCEEEEEEEEE	24.58	-
369	Phosphorylation	GFTWGKVYWEVEVER CCCCEEEEEEEEEEE	10.19	19835603
449	Ubiquitination	ARDSVKRKGDLSLRP CHHHHHHCCCCCCCC	51.57	-
453	Phosphorylation	VKRKGDLSLRPEDGV HHHCCCCCCCCCCCE	27.37	24719451
466	Phosphorylation	GVWALRLSSSGIWAN CEEEEEEECCCCCCC	18.94	28348404
467	Phosphorylation	VWALRLSSSGIWANT EEEEEEECCCCCCCC	36.86	28348404
468	Phosphorylation	WALRLSSSGIWANTS EEEEEECCCCCCCCC	30.81	28348404
474	Phosphorylation	SSGIWANTSPEAELF CCCCCCCCCCHHHHC	37.60	27251275
475	Phosphorylation	SGIWANTSPEAELFP CCCCCCCCCHHHHCC	22.13	27251275
499	Phosphorylation	ALDYEGGTVTFTNAE EEEECCCEEEEECCC	27.51	30576142
503	Phosphorylation	EGGTVTFTNAESQEL CCCEEEEECCCCCCE	24.93	30576142
515	Phosphorylation	QELIYTFTATFTRRL CCEEEEEEECCHHHC	19.58	30576142
529	Ubiquitination	LVPFLWLKWPGTRLL CCCCCEEECCCCEEE	39.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI26_HUMAN	TRIM26	physical	11331580
TRI26_HUMAN	TRIM26	physical	22493164
TRI41_HUMAN	TRIM41	physical	22493164
RN126_HUMAN	RNF126	physical	22493164
PHF7_HUMAN	PHF7	physical	22493164
RNF10_HUMAN	RNF10	physical	22493164
THAP1_HUMAN	THAP1	physical	25416956
TOP1_HUMAN	TOP1	physical	26496610
CSKP_HUMAN	CASK	physical	26496610
CHERP_HUMAN	CHERP	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
MTCH1_HUMAN	MTCH1	physical	26496610
ARFG3_HUMAN	ARFGAP3	physical	26496610
PHF10_HUMAN	PHF10	physical	26496610
EMSY_HUMAN	C11orf30	physical	26496610
IRF3_HUMAN	IRF3	physical	25763818
TBK1_HUMAN	TBK1	physical	26611359
TRI26_HUMAN	TRIM26	physical	26611359

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.