NIP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIP7_HUMAN
• UniProt AC: Q9Y221
• Protein Name: 60S ribosome subunit biogenesis protein NIP7 homolog
• Gene Name: NIP7
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly..
• Protein Sequence: MRPLTEEETRVMFEKIAKYIGENLQLLVDRPDGTYCFRLHNDRVYYVSEKIMKLAANISGDKLVSLGTCFGKFTKTHKFRLHVTALDYLAPYAKYKVWIKPGAEQSFLYGNHVLKSGLGRITENTSQYQGVVVYSMADIPLGFGVAAKSTQDCRKVDPMAIVVFHQADIGEYVRHEETLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MRPLTEEE -------CCCCCHHH	10.06	28183972
5	Phosphorylation	---MRPLTEEETRVM ---CCCCCHHHHHHH	43.99	21406692
9	Phosphorylation	RPLTEEETRVMFEKI CCCCHHHHHHHHHHH	31.66	21406692
15 (in isoform 2)	Ubiquitination	-	36.38	21890473
15 (in isoform 1)	Ubiquitination	-	36.38	21890473
15	Acetylation	ETRVMFEKIAKYIGE HHHHHHHHHHHHHHH	36.38	25953088
15	2-Hydroxyisobutyrylation	ETRVMFEKIAKYIGE HHHHHHHHHHHHHHH	36.38	-
15	Ubiquitination	ETRVMFEKIAKYIGE HHHHHHHHHHHHHHH	36.38	21906983
18	Acetylation	VMFEKIAKYIGENLQ HHHHHHHHHHHHCCE	40.65	26051181
18	Ubiquitination	VMFEKIAKYIGENLQ HHHHHHHHHHHHCCE	40.65	22817900
30	Methylation	NLQLLVDRPDGTYCF CCEEEEECCCCCEEE	24.59	115485009
43	Methylation	CFRLHNDRVYYVSEK EEEECCCEEEEEEHH	24.53	115485001
45	Phosphorylation	RLHNDRVYYVSEKIM EECCCEEEEEEHHHH	10.07	22817900
46	Phosphorylation	LHNDRVYYVSEKIMK ECCCEEEEEEHHHHH	8.47	22817900
50 (in isoform 2)	Ubiquitination	-	40.36	21890473
50 (in isoform 1)	Ubiquitination	-	40.36	21890473
50	Acetylation	RVYYVSEKIMKLAAN EEEEEEHHHHHHHHH	40.36	25953088
50	Ubiquitination	RVYYVSEKIMKLAAN EEEEEEHHHHHHHHH	40.36	22817900
53	Acetylation	YVSEKIMKLAANISG EEEHHHHHHHHHCCC	38.15	25953088
53	Ubiquitination	YVSEKIMKLAANISG EEEHHHHHHHHHCCC	38.15	22817900
62	Ubiquitination	AANISGDKLVSLGTC HHHCCCCEEEEEEEC	55.07	23000965
62	Acetylation	AANISGDKLVSLGTC HHHCCCCEEEEEEEC	55.07	26051181
72	Ubiquitination	SLGTCFGKFTKTHKF EEEECCCCCCCCCCE	29.61	29967540
72	Acetylation	SLGTCFGKFTKTHKF EEEECCCCCCCCCCE	29.61	25825284
88	Phosphorylation	LHVTALDYLAPYAKY EEEEEHHHHHCCEEE	12.96	28152594
92	Phosphorylation	ALDYLAPYAKYKVWI EHHHHHCCEEEEEEE	15.32	28152594
94	Ubiquitination	DYLAPYAKYKVWIKP HHHHCCEEEEEEECC	39.50	21906983
94 (in isoform 1)	Ubiquitination	-	39.50	21890473
94	Acetylation	DYLAPYAKYKVWIKP HHHHCCEEEEEEECC	39.50	25953088
96	Ubiquitination	LAPYAKYKVWIKPGA HHCCEEEEEEECCCC	30.32	22817900
96	Acetylation	LAPYAKYKVWIKPGA HHCCEEEEEEECCCC	30.32	26051181
100	Acetylation	AKYKVWIKPGAEQSF EEEEEEECCCCCHHC	22.99	25953088
100	Ubiquitination	AKYKVWIKPGAEQSF EEEEEEECCCCCHHC	22.99	23503661
101	Ubiquitination	KYKVWIKPGAEQSFL EEEEEECCCCCHHCE	37.79	27667366
106	Phosphorylation	IKPGAEQSFLYGNHV ECCCCCHHCEECCEE	14.55	28152594
109	Phosphorylation	GAEQSFLYGNHVLKS CCCHHCEECCEEECC	17.55	28152594
115	Ubiquitination	LYGNHVLKSGLGRIT EECCEEECCCCCCCC	41.19	22817900
115	Acetylation	LYGNHVLKSGLGRIT EECCEEECCCCCCCC	41.19	26051181
115 (in isoform 1)	Ubiquitination	-	41.19	21890473
148	Ubiquitination	LGFGVAAKSTQDCRK CCCCEECCCCCCCCC	44.28	27667366
155	Ubiquitination	KSTQDCRKVDPMAIV CCCCCCCCCCCEEEE	58.27	-
172	Phosphorylation	HQADIGEYVRHEETL EECCHHHHHCCCCCC	9.51	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOL8_HUMAN	NOL8	physical	14660641
NIP7_HUMAN	NIP7	physical	25416956
NECA2_HUMAN	NECAB2	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
CEBPZ_HUMAN	CEBPZ	physical	26344197
DDX24_HUMAN	DDX24	physical	26344197
NOP53_HUMAN	GLTSCR2	physical	26344197
NOP2_HUMAN	NOP2	physical	26344197
RBM28_HUMAN	RBM28	physical	26344197
DDX24_HUMAN	DDX24	physical	24980433

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.