dbPTM

NOP53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP53_HUMAN
UniProt AC	Q9NZM5
Protein Name	Ribosome biogenesis protein NOP53 {ECO:0000305}
Gene Name	NOP53 {ECO:0000312\|HGNC:HGNC:4333}
Organism	Homo sapiens (Human).
Sequence Length	478
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm . In the nucleolus may be more specifically localized to the fibrillar center (PubMed:27729611). Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enablin
Protein Description	Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. [PubMed: 24120868 In ribosome biogenesis, may also play a role in rRNA transcription]
Protein Sequence	MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEVDQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Acetylation	------MAAGGSGVG ------CCCCCCCCC	22814378
6	Phosphorylation	--MAAGGSGVGGKRS --CCCCCCCCCCCCC	23403867
11	Acetylation	GGSGVGGKRSSKSDA CCCCCCCCCCCCCCC	25953088
11	Ubiquitination	GGSGVGGKRSSKSDA CCCCCCCCCCCCCCC	24816145
13	Phosphorylation	SGVGGKRSSKSDADS CCCCCCCCCCCCCCC	24719451
14	Phosphorylation	GVGGKRSSKSDADSG CCCCCCCCCCCCCCC	30624053
16	Phosphorylation	GGKRSSKSDADSGFL CCCCCCCCCCCCCCC	24732914
20	Phosphorylation	SSKSDADSGFLGLRP CCCCCCCCCCCCCCC	24732914
28	Phosphorylation	GFLGLRPTSVDPALR CCCCCCCCCCCHHHH	21712546
29	Phosphorylation	FLGLRPTSVDPALRR CCCCCCCCCCHHHHH	21712546
35	Methylation	TSVDPALRRRRRGPR CCCCHHHHHHHCCCC	-
73	Phosphorylation	DVRLQERTSGGLLSE HHHCHHHCCCCCCCC	18669648
74	Phosphorylation	VRLQERTSGGLLSEA HHCHHHCCCCCCCCC	21815630
79	Phosphorylation	RTSGGLLSEAPNEKL HCCCCCCCCCCCCCE	23312004
85	Ubiquitination	LSEAPNEKLFFVDTG CCCCCCCCEEEEECC	21906983
91	Phosphorylation	EKLFFVDTGSKEKGL CCEEEEECCCCCCCC	29255136
93	Phosphorylation	LFFVDTGSKEKGLTK EEEEECCCCCCCCCC	29255136
94	Ubiquitination	FFVDTGSKEKGLTKK EEEECCCCCCCCCCC	33845483
94	Acetylation	FFVDTGSKEKGLTKK EEEECCCCCCCCCCC	26051181
103	Phosphorylation	KGLTKKRTKVQKKSL CCCCCCCCHHHHHHH	-
104	Acetylation	GLTKKRTKVQKKSLL CCCCCCCHHHHHHHH	7668829
107	Acetylation	KKRTKVQKKSLLLKK CCCCHHHHHHHHHCC	7668839
113	Ubiquitination	QKKSLLLKKPLRVDL HHHHHHHCCCCCCEE	27667366
114	Acetylation	KKSLLLKKPLRVDLI HHHHHHCCCCCCEEE	26051181
143	Ubiquitination	AHQVPNAKKLRRKEQ HHCCCCHHHHHHHHH	33845483
154	Ubiquitination	RKEQLWEKLAKQGEL HHHHHHHHHHHCCCC	29967540
157	Ubiquitination	QLWEKLAKQGELPRE HHHHHHHHCCCCCHH	-
176	Phosphorylation	QARLLNPSATRAKPG HHHHHCCCCCCCCCC	23312004
178	Phosphorylation	RLLNPSATRAKPGPQ HHHCCCCCCCCCCCC	30576142
204	Methylation	ASDNPLDRPLVGQDE CCCCCCCCCCCCCHH	-
233	Phosphorylation	ARLHTKPSQAPAVEV CCCCCCCCCCCCEEE	-
256	Phosphorylation	PSFEDHQTLLSAAHE CCHHHHHHHHHHHHH	-
274	Ubiquitination	QRQKEAEKLERQLAL HHHHHHHHHHHHHHC	24816145
284	Phosphorylation	RQLALPATEQAATQE HHHHCCHHHHHHHCH	28634120
289	Phosphorylation	PATEQAATQESTFQE CHHHHHHHCHHHHHH	28348404
292	Phosphorylation	EQAATQESTFQELCE HHHHHCHHHHHHHHH	28348404
293	Phosphorylation	QAATQESTFQELCEG HHHHCHHHHHHHHHH	28348404
305	Phosphorylation	CEGLLEESDGEGEPG HHHHHHHCCCCCCCC	20873877
327	Phosphorylation	GDAEVCPTPARLATT CCCCCCCCHHHHHCC	26074081
333	Phosphorylation	PTPARLATTEKKTEQ CCHHHHHCCCHHHHH	26074081
334	Phosphorylation	TPARLATTEKKTEQQ CHHHHHCCCHHHHHH	26074081
337	Ubiquitination	RLATTEKKTEQQRRR HHHCCCHHHHHHHHH	24816145
338	Phosphorylation	LATTEKKTEQQRRRE HHCCCHHHHHHHHHH	26074081
375	Ubiquitination	LFRLRGIKAQVALRL HHHHHCHHHHHHHHH	-
381	Methylation	IKAQVALRLAELARR HHHHHHHHHHHHHHH	-
402	Ubiquitination	RREAEADKPRRLGRL HHHHHCCCCHHHCCC	24816145
427	Phosphorylation	LSSELTDSLRTLKPE ECHHHHHHHHHCCCC	24173317
432	Ubiquitination	TDSLRTLKPEGNILR HHHHHHCCCCCCHHH	23000965
444	Phosphorylation	ILRDRFKSFQRRNMI HHHHHHHHHHHHCCC	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
233	S	Phosphorylation	Kinase	ATM	Q13315	PSP
289	T	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
MDM2_HUMAN	MDM2	physical	21988832
IF6_HUMAN	EIF6	physical	24778252
MPP10_HUMAN	MPHOSPH10	physical	26344197
RRP12_HUMAN	RRP12	physical	26344197
P53_HUMAN	TP53	physical	22522597
MERL_HUMAN	NF2	physical	21167305
DDX58_HUMAN	DDX58	physical	27824081
UBP15_HUMAN	USP15	physical	27824081
CDN2A_HUMAN	CDKN2A	physical	27323397
ARF_HUMAN	CDKN2A	physical	27323397
NOP53_HUMAN	GLTSCR2	physical	24735870
OSBL6_HUMAN	OSBPL6	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
ZN189_HUMAN	ZNF189	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
MKRN1_HUMAN	MKRN1	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
PRR3_HUMAN	PRR3	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
TRI27_HUMAN	TRIM27	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
ZNF16_HUMAN	ZNF16	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
SUN2_HUMAN	SUN2	physical	28514442
ZCHC9_HUMAN	ZCCHC9	physical	28514442
ZN121_HUMAN	ZNF121	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
TSYL2_HUMAN	TSPYL2	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
RT22_HUMAN	MRPS22	physical	28514442
UIF_HUMAN	FYTTD1	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RL5_HUMAN	RPL5	physical	28514442
NMNA1_HUMAN	NMNAT1	physical	28514442
IMP4_HUMAN	IMP4	physical	28514442
FRIL_HUMAN	FTL	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
NGRN_HUMAN	NGRN	physical	28514442
YBOX1_HUMAN	YBX1	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
CTCF_HUMAN	CTCF	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP53_HUMAN

Related Literatures of Post-Translational Modification