ZN189_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN189_HUMAN
• UniProt AC: O75820
• Protein Name: Zinc finger protein 189
• Gene Name: ZNF189
• Organism: Homo sapiens (Human).
• Sequence Length: 626
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MASPSPPPESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKTQETHECDACGEAFNCRISLIQHQKLHTAWMQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	25.31	25056879
3	Phosphorylation	-----MASPSPPPES -----CCCCCCCCCC	25.31	25850435
5	Phosphorylation	---MASPSPPPESKG ---CCCCCCCCCCCC	47.76	25850435
5 (in isoform 2)	Phosphorylation	-	47.76	25159151
10 (in isoform 2)	Phosphorylation	-	37.48	22115753
10	Phosphorylation	SPSPPPESKGLLTFE CCCCCCCCCCCCCHH	37.48	30177828
67	Sumoylation	KDEEPTVKQEIEEIE CCCCCCHHHHHHHHH	44.70	28112733
88	Sumoylation	GVIVTRIKSEIDQDP CEEEEEECCCCCCCC	38.45	-
88	Sumoylation	GVIVTRIKSEIDQDP CEEEEEECCCCCCCC	38.45	28112733
160	Sumoylation	CGKGFVRKAHFIQHQ HCCCHHHHHHHHCCC	40.69	28112733
171	Phosphorylation	IQHQRVHTGEKPFQC HCCCCCCCCCCCEEC	44.15	29214152
184	Phosphorylation	QCNECGKSFSRSSFV ECCCCCCCCCCCCEE	17.46	21949786
186	Phosphorylation	NECGKSFSRSSFVIE CCCCCCCCCCCEEEE	38.04	23684312
188	Phosphorylation	CGKSFSRSSFVIEHQ CCCCCCCCCEEEEEC	27.25	21949786
189	Phosphorylation	GKSFSRSSFVIEHQR CCCCCCCCEEEEECE	23.56	21949786
227	Phosphorylation	IRHQRIHTGERPYQC EECCCCCCCCCCCCC	38.06	27732954
281	Phosphorylation	HLIEHQRTHTGEKPY HHHHCCCCCCCCCCC	19.74	-
283	Phosphorylation	IEHQRTHTGEKPYHC HHCCCCCCCCCCCCC	46.56	-
298	Phosphorylation	TKCKKSFSRNSLLVE CCCCCCCCCCCEEEE	37.33	17081983
301	Phosphorylation	KKSFSRNSLLVEHQR CCCCCCCCEEEEEEE	23.21	28555341
328	Phosphorylation	CGKAFRLSTYLIQHQ CCHHHHHHHHHHCCC	15.68	24719451
330	Phosphorylation	KAFRLSTYLIQHQKI HHHHHHHHHHCCCCC	9.83	28555341
339	Phosphorylation	IQHQKIHTGEKPFLC HCCCCCCCCCCCEEE	50.97	21712546
354	Phosphorylation	IECGKSFSRSSFLIE EECCCCCCCCCEEEE	38.04	17081983
367	Phosphorylation	IEHQRIHTGERPYQC EEECCCCCCCCCCCC	38.06	27732954
395	Phosphorylation	TRHQRIHTGDKPHKC HHCCCCCCCCCCCCC	44.71	20068231
412	Phosphorylation	CGKAFSRSSGLIQHQ HHHHHHCCCCCCCCC	27.79	28555341
428	Phosphorylation	IHTREKTYPYNETKE EECCCCCCCCCCCCC	18.13	29759185
430	Phosphorylation	TREKTYPYNETKESF CCCCCCCCCCCCCCC	18.41	29759185
434	Sumoylation	TYPYNETKESFDPNC CCCCCCCCCCCCCCC	45.22	28112733
452	Sumoylation	IQQEVYPKEKSYKCD EEEECCCCCCCEECC	61.15	28112733
456	Phosphorylation	VYPKEKSYKCDECGK CCCCCCCEECCCCCC	27.06	22817900
479	Phosphorylation	VQHQRIHTGEKPYLC EECCCCCCCCCCEEE	44.67	28111955
494	Phosphorylation	TVCGKSFSRSSFLIE EECCCCCCCCCEEEE	38.04	17081983
550	Phosphorylation	DECGKAFSRNSGLIQ CCCCCCHHCCCCCCC	35.10	28555341
553	Phosphorylation	GKAFSRNSGLIQHQR CCCHHCCCCCCCCCE	33.59	28555341
563	Phosphorylation	IQHQRIHTGEKPYKC CCCCEEECCCCCCCC	44.67	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN189_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN189_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN189_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN189_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.