| UniProt ID | LIN41_HUMAN | |
|---|---|---|
| UniProt AC | Q2Q1W2 | |
| Protein Name | E3 ubiquitin-protein ligase TRIM71 | |
| Gene Name | TRIM71 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 868 | |
| Subcellular Localization | Cytoplasm, P-body . | |
| Protein Description | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. [PubMed: 23125361 Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression] | |
| Protein Sequence | MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASFPETDF ------CCCCCCCHH | 21.63 | 21406692 | |
| 3 | Phosphorylation | -----MASFPETDFQ -----CCCCCCCHHH | 39.78 | 21406692 | |
| 7 | Phosphorylation | -MASFPETDFQICLL -CCCCCCCHHHHHHH | 42.21 | 21406692 | |
| 88 | Ubiquitination | GAAGEPLKLRCPVCD CCCCCCCCCCCCCCC | 44.60 | - | |
| 187 | Phosphorylation | APGGPAASPSALLLR CCCCCCCCHHHEECC | 22.84 | 19664995 | |
| 189 | Phosphorylation | GGPAASPSALLLRRP CCCCCCHHHEECCCC | 29.11 | 19664995 | |
| 325 | Phosphorylation | LQDSRALTIQLLADA HHCCCHHHHHHHHHH | 12.99 | 27174698 | |
| 395 | Ubiquitination | KIRQVKAKSLYLQVE HHHHHCHHHHHHHHH | 34.96 | 32142685 | |
| 396 | Phosphorylation | IRQVKAKSLYLQVEK HHHHCHHHHHHHHHH | 27.40 | 29396449 | |
| 398 | Phosphorylation | QVKAKSLYLQVEKLR HHCHHHHHHHHHHHH | 11.37 | 29396449 | |
| 445 | Ubiquitination | LAQVQELKTVRSLLQ HHHHHHHHHHHHHCC | 44.19 | - | |
| 487 | Phosphorylation | SGAFAPLTKATGDGL CCCCCCCCHHCCHHH | 19.99 | - | |
| 495 | Methylation | KATGDGLKRALQGKV HHCCHHHHHHHCCCE | 40.95 | - | |
| 749 | Phosphorylation | ALWKHFDSPRGVAFN CHHHCCCCCCCEEEE | 18.62 | 24719451 | |
| 836 | Phosphorylation | CKFGAQGSGFGQMDR EEECCCCCCCCCCCC | 20.90 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LIN41_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LIN41_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LIN41_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LN28B_HUMAN | LIN28B | physical | 24602972 | |
| AGO2_HUMAN | AGO2 | physical | 24602972 | |
| DICER_HUMAN | DICER1 | physical | 24602972 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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