IMP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMP4_HUMAN
• UniProt AC: Q96G21
• Protein Name: U3 small nucleolar ribonucleoprotein protein IMP4
• Gene Name: IMP4
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing..
• Protein Sequence: MLRREARLRREYLYRKAREEAQRSAQERKERLRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	EARLRREYLYRKARE HHHHHHHHHHHHHHH	13.76	29496907
44	Phosphorylation	EENRLIPTELRREAL HHCCCCCHHHHHHHH	40.43	24719451
75	Phosphorylation	TSHVDDEYRWAGVED CCCCCCCCEECCCCC	20.60	-
84	Ubiquitination	WAGVEDPKVMITTSR ECCCCCCCEEEECCC	57.67	21906983
84	Ubiquitination	WAGVEDPKVMITTSR ECCCCCCCEEEECCC	57.67	21890473
88	Phosphorylation	EDPKVMITTSRDPSS CCCCEEEECCCCHHH	10.71	20068231
89	Phosphorylation	DPKVMITTSRDPSSR CCCEEEECCCCHHHH	15.73	20068231
90	Phosphorylation	PKVMITTSRDPSSRL CCEEEECCCCHHHHH	26.49	20068231
94	Phosphorylation	ITTSRDPSSRLKMFA EECCCCHHHHHHHHH	32.17	20068231
95	Phosphorylation	TTSRDPSSRLKMFAK ECCCCHHHHHHHHHH	47.20	20068231
102	Acetylation	SRLKMFAKELKLVFP HHHHHHHHHHHHHCC	52.92	21466224
102	Ubiquitination	SRLKMFAKELKLVFP HHHHHHHHHHHHHCC	52.92	-
105	Acetylation	KMFAKELKLVFPGAQ HHHHHHHHHHCCCHH	43.63	21466224
105	Ubiquitination	KMFAKELKLVFPGAQ HHHHHHHHHHCCCHH	43.63	-
129	Ubiquitination	GALVRACKANGVTDL HHHHHHHHHCCCCEE	43.85	-
180	Phosphorylation	IPDLGTMSEAKPHLI CCCCCCCCCCCCHHH	33.95	22210691
183	Acetylation	LGTMSEAKPHLITHG CCCCCCCCCHHHHHC	28.99	26051181
183	Ubiquitination	LGTMSEAKPHLITHG CCCCCCCCCHHHHHC	28.99	21890473
183	Ubiquitination	LGTMSEAKPHLITHG CCCCCCCCCHHHHHC	28.99	21890473
205	Phosphorylation	RVSDILRYLFPVPKD HHHHHHHHHCCCCCC	14.84	23612710
211	Ubiquitination	RYLFPVPKDDSHRVI HHHCCCCCCCCCCEE	74.52	-
226	Phosphorylation	TFANQDDYISFRHHV EECCCCCEEEECCEE	13.52	28152594
228	Phosphorylation	ANQDDYISFRHHVYK CCCCCEEEECCEEEC	15.25	28152594
237	Phosphorylation	RHHVYKKTDHRNVEL CCEEECCCCCCCEEE	32.65	20068231
245	Phosphorylation	DHRNVELTEVGPRFE CCCCEEEEEECCHHE	18.34	20068231
256	Phosphorylation	PRFELKLYMIRLGTL CHHEEEEEEEECCCC	6.73	20068231
290	Phosphorylation	RKRVFLSTE------ CCEEEEECC------	48.11	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPP10_HUMAN	MPHOSPH10	physical	12655004
A4_HUMAN	APP	physical	21832049
NAT10_HUMAN	NAT10	physical	26344197
NOL10_HUMAN	NOL10	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.