NOL10_HUMAN - dbPTM
NOL10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOL10_HUMAN
UniProt AC Q9BSC4
Protein Name Nucleolar protein 10
Gene Name NOL10
Organism Homo sapiens (Human).
Sequence Length 688
Subcellular Localization Nucleus, nucleolus .
Protein Description
Protein Sequence MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEGKPSDAESSESSDDEKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKIEAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKRLRRSAGHLKSRHKRGRSFH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MQVSSLNE
-------CCCCCCCC		8.8422223895
2 (in isoform 3)Phosphorylation-43.7424043423
3 (in isoform 3)Phosphorylation-3.9724043423
5 (in isoform 3)Phosphorylation-36.0424043423
6 (in isoform 3)Phosphorylation-5.0224043423
9 (in isoform 3)Phosphorylation-4.4324043423
12PhosphorylationSLNEVKIYSLSCGKS
CCCCEEEEEECCCCC		9.6129496907
13PhosphorylationLNEVKIYSLSCGKSL
CCCEEEEEECCCCCH		19.7829083192
15PhosphorylationEVKIYSLSCGKSLPE
CEEEEEECCCCCHHH		18.1929083192
18UbiquitinationIYSLSCGKSLPEWLS
EEEECCCCCHHHHHH		53.8229967540
18AcetylationIYSLSCGKSLPEWLS
EEEECCCCCHHHHHH		53.8225953088
19PhosphorylationYSLSCGKSLPEWLSD
EEECCCCCHHHHHHH		34.1529083192
25PhosphorylationKSLPEWLSDRKKRAL
CCHHHHHHHHHHHHH		36.1221815630
35UbiquitinationKKRALQKKDVDVRRR
HHHHHHHCCCCHHHH		50.4524816145
62UbiquitinationCTTIKVSKDGQYILA
EEEEEECCCCCEEEE		69.71-
74AcetylationILATGTYKPRVRCYD
EEECEEECCCEEEEC		26.6225953088
74UbiquitinationILATGTYKPRVRCYD
EEECEEECCCEEEEC		26.6227667366
74 (in isoform 2)Ubiquitination-26.6221890473
74 (in isoform 1)Ubiquitination-26.6221890473
74UbiquitinationILATGTYKPRVRCYD
EEECEEECCCEEEEC		26.6221890473
88AcetylationDTYQLSLKFERCLDS
CEEEEEEEEEHHCCC		41.6326051181
191UbiquitinationINSVHGLFATGTIEG
CCCCEEEEECCEEEE		7.2824816145
248UbiquitinationALTMAVGTTTGQVLL
EEEEEEECCCCEEEE		18.0024816145
260PhosphorylationVLLYDLRSDKPLLVK
EEEEECCCCCCEEEE		58.2320860994
262UbiquitinationLYDLRSDKPLLVKDH
EEECCCCCCEEEEEE		38.52-
267UbiquitinationSDKPLLVKDHQYGLP
CCCCEEEEEECCCCC		49.84-
271PhosphorylationLLVKDHQYGLPIKSV
EEEEEECCCCCCCEE		19.7427642862
278UbiquitinationYGLPIKSVHFQDSLD
CCCCCCEEECCHHHH		4.4429967540
287UbiquitinationFQDSLDLILSADSRI
CCHHHHHHHCCCHHH		2.5924816145
296UbiquitinationSADSRIVKMWNKNSG
CCCHHHHHEEECCCC		35.51-
304UbiquitinationMWNKNSGKIFTSLEP
EEECCCCCCCCCCCC		34.1729967540
339PhosphorylationETPKMGIYYIPVLGP
CCCCCEEEEEEECCC		6.9323917254
340PhosphorylationTPKMGIYYIPVLGPA
CCCCEEEEEEECCCC		9.2322817900
366UbiquitinationEELEENPESTVYDDY
HHHHHCCCCCCCCCC		71.3024816145
392PhosphorylationGLTHLIGSPFLRAYM
CHHHHHCCHHHHHHH		12.89-
401UbiquitinationFLRAYMHGFFMDIRL
HHHHHHHCHHCHHHH		10.8529967540
406UbiquitinationMHGFFMDIRLYHKVK
HHCHHCHHHHHHHEE		1.8829967540
413AcetylationIRLYHKVKLMVNPFA
HHHHHHEEEEECCCC		35.3526051181
414 (in isoform 2)Ubiquitination-5.3321890473
423UbiquitinationVNPFAYEEYRKDKIR
ECCCCHHHHHHHHHH		37.6524816145
425UbiquitinationPFAYEEYRKDKIRQK
CCCHHHHHHHHHHHH		43.9329967540
428UbiquitinationYEEYRKDKIRQKIEE
HHHHHHHHHHHHHHH		42.71-
430UbiquitinationEYRKDKIRQKIEETR
HHHHHHHHHHHHHHH		37.1629967540
432SumoylationRKDKIRQKIEETRAQ
HHHHHHHHHHHHHHH		42.09-
432SumoylationRKDKIRQKIEETRAQ
HHHHHHHHHHHHHHH		42.09-
451UbiquitinationKKLPKVNKELALKLI
HHCCCCCHHHHHHHH		58.0329967540
456UbiquitinationVNKELALKLIEEEEE
CCHHHHHHHHHHHHH		41.6429967540
462UbiquitinationLKLIEEEEEKQKSTW
HHHHHHHHHHHHCHH		74.0024816145
464UbiquitinationLIEEEEEKQKSTWKK
HHHHHHHHHHCHHHH		67.322190698
464 (in isoform 1)Ubiquitination-67.3221890473
466UbiquitinationEEEEEKQKSTWKKKV
HHHHHHHHCHHHHHH		62.0024816145
475PhosphorylationTWKKKVKSLPNILTD
HHHHHHHCCCCCCCC		52.6325159151
481PhosphorylationKSLPNILTDDRFKVM
HCCCCCCCCCCEEEE		31.8623186163
490UbiquitinationDRFKVMFENPDFQVD
CCEEEEECCCCCCCC		50.1624816145
500PhosphorylationDFQVDEESEEFRLLN
CCCCCCCCHHHHHHH		40.1420873877
511PhosphorylationRLLNPLVSKISEKRK
HHHHHHHHHHCHHHH		31.7720068231
514PhosphorylationNPLVSKISEKRKKKL
HHHHHHHCHHHHHHH		40.5825159151
516UbiquitinationLVSKISEKRKKKLRL
HHHHHCHHHHHHHHH		63.8324816145
523UbiquitinationKRKKKLRLLEQQELR
HHHHHHHHHHHHHHH		10.0124816145
539UbiquitinationKEEEEEPEGKPSDAE
HHHHCCCCCCCCCCC		81.0229967540
543PhosphorylationEEPEGKPSDAESSES
CCCCCCCCCCCCCCC		53.6020363803
546UbiquitinationEGKPSDAESSESSDD
CCCCCCCCCCCCCHH		60.8429967540
547UbiquitinationGKPSDAESSESSDDE
CCCCCCCCCCCCHHH		40.9224816145
547PhosphorylationGKPSDAESSESSDDE
CCCCCCCCCCCCHHH		40.9220363803
548PhosphorylationKPSDAESSESSDDEK
CCCCCCCCCCCHHHH		32.7620363803
550PhosphorylationSDAESSESSDDEKAW
CCCCCCCCCHHHHHH		40.8020363803
551PhosphorylationDAESSESSDDEKAWV
CCCCCCCCHHHHHHH		45.0620363803
555UbiquitinationSESSDDEKAWVEEVR
CCCCHHHHHHHHHHH		55.3229967540
562UbiquitinationKAWVEEVRKQRRLLQ
HHHHHHHHHHHHHHH		32.4424816145
563UbiquitinationAWVEEVRKQRRLLQQ
HHHHHHHHHHHHHHH		54.0229967540
570UbiquitinationKQRRLLQQEEKVKRQ
HHHHHHHHHHHHHHH		61.8729967540
573UbiquitinationRLLQQEEKVKRQERL
HHHHHHHHHHHHHHH		52.9124816145
579UbiquitinationEKVKRQERLKEDQQT
HHHHHHHHHHHHHCH		42.6029967540
586UbiquitinationRLKEDQQTVLKPQFY
HHHHHHCHHHCHHEE		23.3624816145
589UbiquitinationEDQQTVLKPQFYEIK
HHHCHHHCHHEEEEC		32.2229967540
589AcetylationEDQQTVLKPQFYEIK
HHHCHHHCHHEEEEC		32.2225953088
593PhosphorylationTVLKPQFYEIKAGEE
HHHCHHEEEECCCHH		16.1128152594
596UbiquitinationKPQFYEIKAGEEFRS
CHHEEEECCCHHHHC		38.1029967540
603PhosphorylationKAGEEFRSFKDSATK
CCCHHHHCCCCHHHH		41.8028555341
605UbiquitinationGEEFRSFKDSATKQK
CHHHHCCCCHHHHHH		52.6129967540
607PhosphorylationEFRSFKDSATKQKLM
HHHCCCCHHHHHHHH		38.1324732914
609PhosphorylationRSFKDSATKQKLMNK
HCCCCHHHHHHHHCC		37.6520860994
612UbiquitinationKDSATKQKLMNKTLE
CCHHHHHHHHCCCHH		51.7824816145
630PhosphorylationKIEAKNGTLSVSDTT
CCEECCCEEEEECCC		25.8320068231
632PhosphorylationEAKNGTLSVSDTTVG
EECCCEEEEECCCCC		21.2925159151
634PhosphorylationKNGTLSVSDTTVGSK
CCCEEEEECCCCCEE		26.3420068231
636PhosphorylationGTLSVSDTTVGSKQL
CEEEEECCCCCEEEE		18.8420068231
637PhosphorylationTLSVSDTTVGSKQLT
EEEEECCCCCEEEEE		28.0620068231
640PhosphorylationVSDTTVGSKQLTFTL
EECCCCCEEEEEEEE		16.9420068231
661AcetylationKKQQEAEKLHRQERK
HHHHHHHHHHHHHHH		57.5525953088
673PhosphorylationERKRLRRSAGHLKSR
HHHHHHHHHHHHHHH		31.97-
686PhosphorylationSRHKRGRSFH-----
HHHHCCCCCC-----		30.42-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOL10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOL10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOL10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AATF_HUMANAATFphysical
26344197
GRWD1_HUMANGRWD1physical
26344197
NOL6_HUMANNOL6physical
26344197
PPP5_HUMANPPP5Cphysical
26344197
RBM19_HUMANRBM19physical
26344197
WDR36_HUMANWDR36physical
26344197
NGDN_HUMANNGDNphysical
28514442
AATF_HUMANAATFphysical
28514442
DDX47_HUMANDDX47physical
28514442
NAT10_HUMANNAT10physical
28514442
RS2_HUMANRPS2physical
28514442
TCPH_HUMANCCT7physical
28514442
TCPG_HUMANCCT3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOL10_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.

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