dbPTM

UIF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UIF_HUMAN
UniProt AC	Q96QD9
Protein Name	UAP56-interacting factor
Gene Name	FYTTD1
Organism	Homo sapiens (Human).
Sequence Length	318
Subcellular Localization	Nucleus, nucleoplasm . Nucleus speckle .
Protein Description	Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4..
Protein Sequence	MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRATLTYNKGGSRFVTVG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNRFGTRL -------CCCCCCCC	7.98	19413330
6	Phosphorylation	--MNRFGTRLVGATA --CCCCCCCCCCCCC	20.37	30576142
12	Phosphorylation	GTRLVGATATSSPPP CCCCCCCCCCCCCCC	25.25	30266825
14	Phosphorylation	RLVGATATSSPPPKA CCCCCCCCCCCCCCC	25.94	30266825
15	Phosphorylation	LVGATATSSPPPKAR CCCCCCCCCCCCCCC	38.08	29255136
16	Phosphorylation	VGATATSSPPPKARS CCCCCCCCCCCCCCC	36.75	29255136
20	Ubiquitination	ATSSPPPKARSNENL CCCCCCCCCCCCCCH	63.31	-
23	Phosphorylation	SPPPKARSNENLDKI CCCCCCCCCCCHHHH	54.04	30266825
33	Phosphorylation	NLDKIDMSLDDIIKL CHHHHCCCHHHHHHH	25.54	23403867
39	Ubiquitination	MSLDDIIKLNRKEGK CCHHHHHHHHHHCHH	39.79	-
61	Phosphorylation	NRRLLQQSGAQQFRM HHHHHHHHCCHHHHH	24.12	22115753
118 (in isoform 4)	Phosphorylation	-	27.11	25056879
118	Phosphorylation	TGIRKGISPMNRPPL CCCCCCCCCCCCCCC	27.11	30266825
126	Phosphorylation	PMNRPPLSDKNIEQY CCCCCCCCCCCHHHH	52.92	30266825
138	Ubiquitination	EQYFPVLKRKANLLR HHHHHHHHHHHHHHH	52.68	-
140	Sumoylation	YFPVLKRKANLLRQN HHHHHHHHHHHHHHC	39.79	-
140	Acetylation	YFPVLKRKANLLRQN HHHHHHHHHHHHHHC	39.79	7677927
140	Sumoylation	YFPVLKRKANLLRQN HHHHHHHHHHHHHHC	39.79	28112733
152	Acetylation	RQNEGQRKPVAVLKR HHCCCCCCCEEEECC	35.64	7677937
161	Phosphorylation	VAVLKRPSQLSRKNN EEEECCHHHHHHCCC	48.03	30266825
166	Ubiquitination	RPSQLSRKNNIPANF CHHHHHHCCCCCCCC	51.47	-
179	Ubiquitination	NFTRSGNKLNHQKDT CCCCCCCCCCCCCCH	54.94	-
205	Phosphorylation	KVQAQLNTEQLLDDV CEEEECCHHHHHHHH	33.43	-
215	Ubiquitination	LLDDVVAKRTRQWRT HHHHHHHHHCCCCCC	42.57	-
235	Acetylation	GILTVSIDNPGAVQC CEEEEEECCCCCEEC	48.00	19413330
253	Phosphorylation	QKPRLTRTAVPSFLT CCCCCCCCCCCCHHH	27.11	28555341
257	Phosphorylation	LTRTAVPSFLTKREQ CCCCCCCCHHHHHCH	26.70	23898821
260	Phosphorylation	TAVPSFLTKREQSDV CCCCCHHHHHCHHCC	26.50	23898821
261	Ubiquitination	AVPSFLTKREQSDVK CCCCHHHHHCHHCCC	56.96	19413330
261	Acetylation	AVPSFLTKREQSDVK CCCCHHHHHCHHCCC	56.96	19413330
282	Phosphorylation	PLQFDINSVGKQTGM CCEEEECCHHHHHCC	32.36	21406692
290	Phosphorylation	VGKQTGMTLNERFGI HHHHHCCCHHHHHCC	27.98	-
299	Ubiquitination	NERFGILKEQRATLT HHHHCCCHHCEEEEE	50.29	-
304	Phosphorylation	ILKEQRATLTYNKGG CCHHCEEEEEEECCC	23.09	24173317
309	Ubiquitination	RATLTYNKGGSRFVT EEEEEEECCCCEEEE	54.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
205	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UIF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UIF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DX39B_HUMAN	DDX39B	physical	19836239
NXF1_HUMAN	NXF1	physical	19836239
HTSF1_HUMAN	HTATSF1	physical	19836239
NUCL_HUMAN	NCL	physical	19836239
SSRP1_HUMAN	SSRP1	physical	19836239
UIF_HUMAN	FYTTD1	physical	19836239
TBB5_HUMAN	TUBB	physical	19836239
PAIRB_HUMAN	SERBP1	physical	19836239
STRAP_HUMAN	STRAP	physical	19836239
C1QBP_HUMAN	C1QBP	physical	19836239
AN32E_HUMAN	ANP32E	physical	19836239
SET_HUMAN	SET	physical	19836239
SP16H_HUMAN	SUPT16H	physical	19836239
PALM_HUMAN	PALM	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
ERIC5_HUMAN	ERICH5	physical	26186194
GBG10_HUMAN	GNG10	physical	26186194
PTPRG_HUMAN	PTPRG	physical	26186194
GNAZ_HUMAN	GNAZ	physical	26186194
GNA11_HUMAN	GNA11	physical	26186194
GNAQ_HUMAN	GNAQ	physical	26186194
GNA13_HUMAN	GNA13	physical	26186194
YES_HUMAN	YES1	physical	26186194
SRC_HUMAN	SRC	physical	26186194
CHTOP_HUMAN	CHTOP	physical	26186194
LASP1_HUMAN	LASP1	physical	26186194
UBA6_HUMAN	UBA6	physical	26186194
EEPD1_HUMAN	EEPD1	physical	26186194
CYB5_HUMAN	CYB5A	physical	26186194
GBG5_HUMAN	GNG5	physical	26186194
CCNY_HUMAN	CCNY	physical	26186194
CCYL1_HUMAN	CCNYL1	physical	26186194
PRRC1_HUMAN	PRRC1	physical	26186194
GBG7_HUMAN	GNG7	physical	26186194
EPCR_HUMAN	PROCR	physical	26186194
TARA_HUMAN	TRIOBP	physical	26186194
CHTOP_HUMAN	CHTOP	physical	28514442
CCYL1_HUMAN	CCNYL1	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
LASP1_HUMAN	LASP1	physical	28514442
OCC1_HUMAN	C12orf75	physical	28514442
PTPRG_HUMAN	PTPRG	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
SRC_HUMAN	SRC	physical	28514442
UBA6_HUMAN	UBA6	physical	28514442
EEPD1_HUMAN	EEPD1	physical	28514442
PRRC1_HUMAN	PRRC1	physical	28514442
XRCC4_HUMAN	XRCC4	physical	28514442
GBG5_HUMAN	GNG5	physical	28514442
PALM_HUMAN	PALM	physical	28514442
GBG10_HUMAN	GNG10	physical	28514442
TARA_HUMAN	TRIOBP	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
GNAZ_HUMAN	GNAZ	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UIF_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-15 AND SER-16, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-15 AND SER-16, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.	16964243 [Abstract]