CYB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYB5_HUMAN
• UniProt AC: P00167
• Protein Name: Cytochrome b5
• Gene Name: CYB5A
• Organism: Homo sapiens (Human).
• Sequence Length: 134
• Subcellular Localization: Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.; Isoform 2: Cytoplasm.
• Protein Description: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases..
• Protein Sequence: MAEQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTDAREMSKTFIIGELHPDDRPKLNKPPETLITTIDSSSSWWTNWVIPAISAVAVALMYRLYMAED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQSDEAV ------CCCCHHHHH	24.44	2752049
5	Phosphorylation	---MAEQSDEAVKYY ---CCCCHHHHHHHH	28.99	24719451
10	Acetylation	EQSDEAVKYYTLEEI CCHHHHHHHHCHHHH	39.32	-
10	Ubiquitination	EQSDEAVKYYTLEEI CCHHHHHHHHCHHHH	39.32	21890473
10 (in isoform 2)	Ubiquitination	-	39.32	21890473
10 (in isoform 1)	Ubiquitination	-	39.32	21890473
11	Phosphorylation	QSDEAVKYYTLEEIQ CHHHHHHHHCHHHHH	8.62	27642862
19	Acetylation	YTLEEIQKHNHSKST HCHHHHHHCCCCCCE	52.62	23954790
19	Ubiquitination	YTLEEIQKHNHSKST HCHHHHHHCCCCCCE	52.62	19608861
25	Phosphorylation	QKHNHSKSTWLILHH HHCCCCCCEEEEEHH	28.03	28857561
26	Phosphorylation	KHNHSKSTWLILHHK HCCCCCCEEEEEHHH	28.20	28857561
35	Phosphorylation	LILHHKVYDLTKFLE EEEHHHHHHHHHHHH	15.27	-
39 (in isoform 2)	Ubiquitination	-	56.07	21890473
39 (in isoform 1)	Ubiquitination	-	56.07	21890473
39	Ubiquitination	HKVYDLTKFLEEHPG HHHHHHHHHHHHCCC	56.07	21890473
39	Acetylation	HKVYDLTKFLEEHPG HHHHHHHHHHHHCCC	56.07	20167786
52	Methylation	PGGEEVLREQAGGDA CCCHHHHHHHHCCCC	38.87	-
60	Phosphorylation	EQAGGDATENFEDVG HHHCCCCCCCHHHCC	35.88	23312004
69	Phosphorylation	NFEDVGHSTDAREMS CHHHCCCCCCHHHHH	23.27	23312004
70	Phosphorylation	FEDVGHSTDAREMSK HHHCCCCCCHHHHHC	28.18	23312004
76	Phosphorylation	STDAREMSKTFIIGE CCCHHHHHCEEEEEE	24.64	28857561
78	Phosphorylation	DAREMSKTFIIGELH CHHHHHCEEEEEECC	16.86	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYB5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP2E1_HUMAN	CYP2E1	physical	15680923
CP2D6_HUMAN	CYP2D6	physical	15680923
CP3A4_HUMAN	CYP3A4	physical	15680923
CP2A6_HUMAN	CYP2A6	physical	15680923
CP1A2_HUMAN	CYP1A2	physical	15680923
CP1A2_RAT	Cyp1a2	physical	15680923
UD14_HUMAN	UGT1A4	physical	21988832
CP2W1_HUMAN	CYP2W1	physical	21988832
INO1_HUMAN	ISYNA1	physical	26344197
ENDD1_HUMAN	ENDOD1	physical	28514442
HSP7E_HUMAN	HSPA14	physical	28514442
RBG10_HUMAN	RABGAP1L	physical	28514442
RBG1L_HUMAN	RABGAP1L	physical	28514442
PLCD_HUMAN	AGPAT4	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
BAP31_HUMAN	BCAP31	physical	28514442
SNX2_HUMAN	SNX2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00235: Methemoglobinemia
• OMIM Disease
• 250790: Methemoglobinemia CYB5A-related (METHB-CYB5A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.