| UniProt ID | UD14_HUMAN | |
|---|---|---|
| UniProt AC | P22310 | |
| Protein Name | UDP-glucuronosyltransferase 1-4 | |
| Gene Name | UGT1A4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 534 | |
| Subcellular Localization |
Microsome. Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).. | |
| Protein Sequence | MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | VPLPRLATGLLLLLS CCHHHHHHHHHHHHC | 32.71 | - | |
| 21 | Phosphorylation | TGLLLLLSVQPWAES HHHHHHHCCCCCHHC | 20.76 | 22210691 | |
| 28 | Phosphorylation | SVQPWAESGKVLVVP CCCCCHHCCCEEEEC | 35.85 | - | |
| 119 | N-linked_Glycosylation | RSMAIMNNVSLALHR HHHHHHHHHHHHHHH | 13.84 | UniProtKB CARBOHYD | |
| 142 | N-linked_Glycosylation | EALIRHLNATSFDVV HHHHHHHCCCCCCEE | 34.74 | 19159218 | |
| 296 | N-linked_Glycosylation | QEFEAYINASGEHGI HHHHHHHHCCCCCEE | 18.51 | UniProtKB CARBOHYD | |
| 319 | Ubiquitination | VSEIPEKKAMAIADA HHCCCHHHHHHHHHH | 41.55 | 29901268 | |
| 333 | Phosphorylation | ALGKIPQTVLWRYTG HHCCCCHHHHHHCCC | 16.53 | 23403867 | |
| 338 | Phosphorylation | PQTVLWRYTGTRPSN CHHHHHHCCCCCCCH | 9.65 | - | |
| 341 | Phosphorylation | VLWRYTGTRPSNLAN HHHHCCCCCCCHHCC | 31.44 | 23403867 | |
| 344 | Phosphorylation | RYTGTRPSNLANNTI HCCCCCCCHHCCCEE | 40.98 | 23403867 | |
| 348 | N-linked_Glycosylation | TRPSNLANNTILVKW CCCCHHCCCEEEEEE | 49.71 | 19159218 | |
| 350 | Phosphorylation | PSNLANNTILVKWLP CCHHCCCEEEEEECC | 18.59 | 23403867 | |
| 367 | Phosphorylation | DLLGHPMTRAFITHA CCCCCCCHHHHHHCC | 24.24 | 23403867 | |
| 436 | Phosphorylation | KAVINDKSYKENIMR HHHHCCHHHHHHHHH | 44.28 | 15845768 | |
| 438 | Ubiquitination | VINDKSYKENIMRLS HHCCHHHHHHHHHHH | 51.91 | 33845483 | |
| 438 | Acetylation | VINDKSYKENIMRLS HHCCHHHHHHHHHHH | 51.91 | 18530385 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UD14_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UD14_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UD14_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of UD14_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| 143500 | Gilbert syndrome (GILBS) |
| 218800 | Crigler-Najjar syndrome 1 (CN1) |
| 606785 | Crigler-Najjar syndrome 2 (CN2) |
| Kegg Drug | |
| D00354 | Lamotrigine (JAN/USAN/INN); Lamictal (TN) |
| D06273 | Imidafenacin (JAN/INN); Uritos (TN); Staybla (TN) |
| DrugBank | |
| DB06216 | Asenapine |
| DB00363 | Clozapine |
| DB04953 | Ezogabine |
| DB00555 | Lamotrigine |
| DB00683 | Midazolam |
| DB00910 | Paricalcitol |
| DB00675 | Tamoxifen |
| DB00831 | Trifluoperazine |
| DB00313 | Valproic Acid |
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142 AND ASN-348, AND MASSSPECTROMETRY. | |
