dbPTM

CP2W1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CP2W1_HUMAN
UniProt AC	Q8TAV3
Protein Name	Cytochrome P450 2W1
Gene Name	CYP2W1
Organism	Homo sapiens (Human).
Sequence Length	490
Subcellular Localization	Endoplasmic reticulum lumen . Cell membrane . About 8% are expressed on the cell surface.
Protein Description	Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. [PubMed: 16551781]
Protein Sequence	MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	N-linked_Glycosylation	LLGWAPSNITFALLF HHEECCCCCHHHHHH	35.94	20805301
368	Phosphorylation	LPHVPRCTAADTQLG CCCCCCCCCCCCEEC	26.59	24719451
372	Phosphorylation	PRCTAADTQLGGFLL CCCCCCCCEECCEEC	22.44	24719451
463	Phosphorylation	LLPPPGVSPASLDTT CCCCCCCCHHHCCCC	22.21	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CP2W1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CP2W1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CP2W1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT26_HUMAN	ZBTB26	physical	21988832
HS71L_HUMAN	HSPA1L	physical	26186194
BAG1_HUMAN	BAG1	physical	26186194
BAG1_HUMAN	BAG1	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CP2W1_HUMAN

Related Literatures of Post-Translational Modification