CP2E1_HUMAN - dbPTM
CP2E1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP2E1_HUMAN
UniProt AC P05181
Protein Name Cytochrome P450 2E1
Gene Name CYP2E1
Organism Homo sapiens (Human).
Sequence Length 493
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Protein Description Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms..
Protein Sequence MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSALGVTVA
------CCHHHHHHH		32.0024043423
7Phosphorylation-MSALGVTVALLVWA
-CCHHHHHHHHHHHH		9.7724043423
21PhosphorylationAAFLLLVSMWRQVHS
HHHHHHHHHHHHHHH		16.7624043423
56PhosphorylationELKNIPKSFTRLAQR
HHHCCCHHHHHHHHH		26.8821209460
58PhosphorylationKNIPKSFTRLAQRFG
HCCCHHHHHHHHHHC		31.6821209460
69PhosphorylationQRFGPVFTLYVGSQR
HHHCCEEEEEECCEE		19.8821209460
71NitrationFGPVFTLYVGSQRMV
HCCEEEEEECCEEEE		10.33-
74PhosphorylationVFTLYVGSQRMVVMH
EEEEEECCEEEEEHH		12.4521209460
83PhosphorylationRMVVMHGYKAVKEAL
EEEEHHCHHHHHHHH		4.90-
84UbiquitinationMVVMHGYKAVKEALL
EEEHHCHHHHHHHHH		51.8221209460
87UbiquitinationMHGYKAVKEALLDYK
HHCHHHHHHHHHCCC		41.9721209460
94UbiquitinationKEALLDYKDEFSGRG
HHHHHCCCCCCCCCC		50.9129967540
121PhosphorylationIIFNNGPTWKDIRRF
EEECCCCCHHHHHHH		46.6921209460
129PhosphorylationWKDIRRFSLTTLRNY
HHHHHHHCHHHHHHC		24.0121209460
131PhosphorylationDIRRFSLTTLRNYGM
HHHHHCHHHHHHCCC		23.6821209460
132PhosphorylationIRRFSLTTLRNYGMG
HHHHCHHHHHHCCCC		29.0721209460
145PhosphorylationMGKQGNESRIQREAH
CCCCCCHHHHHHHHH		38.3921209460
191PhosphorylationLFRKHFDYNDEKFLR
HHHHCCCCCCHHHHH		24.4626657352
245PhosphorylationNVAEVKEYVSERVKE
HHHHHHHHHHHHHHH		11.98-
247PhosphorylationAEVKEYVSERVKEHH
HHHHHHHHHHHHHHH		20.8421209460
251UbiquitinationEYVSERVKEHHQSLD
HHHHHHHHHHHHCCC		58.5121209460
256PhosphorylationRVKEHHQSLDPNCPR
HHHHHHHCCCCCCCC		30.3121209460
275UbiquitinationCLLVEMEKEKHSAER
HHHHHHHHHCCCHHH		71.4121209460
303PhosphorylationLFFAGTETTSTTLRY
EEECCCCCCCHHHHH		26.3624275569
318PhosphorylationGLLILMKYPEIEEKL
HHHHHHHCHHHHHHH		7.6723532336
318NitrationGLLILMKYPEIEEKL
HHHHHHHCHHHHHHH		7.67-
373PhosphorylationSNLPHEATRDTIFRG
CCCCCHHCCCCEECC		26.5421209460
376PhosphorylationPHEATRDTIFRGYLI
CCHHCCCCEECCEEC		20.8021209460
381NitrationRDTIFRGYLIPKGTV
CCCEECCEECCCCCE		9.37-
387PhosphorylationGYLIPKGTVVVPTLD
CEECCCCCEEEECCH		19.0921209460
410UbiquitinationFPDPEKFKPEHFLNE
CCCHHHCCHHHHCCC		61.6421209460
420UbiquitinationHFLNENGKFKYSDYF
HHCCCCCCCCCCCCC		50.7121209460
422UbiquitinationLNENGKFKYSDYFKP
CCCCCCCCCCCCCCC		47.5321209460
423NitrationNENGKFKYSDYFKPF
CCCCCCCCCCCCCCC		15.20-
424PhosphorylationENGKFKYSDYFKPFS
CCCCCCCCCCCCCCC		26.8221209460
428UbiquitinationFKYSDYFKPFSTGKR
CCCCCCCCCCCCCCC		38.6321209460
431PhosphorylationSDYFKPFSTGKRVCA
CCCCCCCCCCCCCCC		44.7921209460
432PhosphorylationDYFKPFSTGKRVCAG
CCCCCCCCCCCCCCC		47.2921209460
434UbiquitinationFKPFSTGKRVCAGEG
CCCCCCCCCCCCCHH		41.5721209460
461UbiquitinationILQHFNLKPLVDPKD
HHHHCCCCCCCCHHH		37.092120946
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
129SPhosphorylationKinasePKA-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP2E1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CP2E1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCPR_HUMANPORphysical
15680923
LAMC3_HUMANLAMC3physical
21988832
ECHM_HUMANECHS1physical
21988832
GATM_HUMANGATMphysical
21988832
MAFG_HUMANMAFGphysical
21988832
PTN_HUMANPTNphysical
21988832
NMI_HUMANNMIphysical
21988832
RL13A_HUMANRPL13Aphysical
21988832
NCPR_HUMANPORphysical
15980100
RMD1_HUMANRMDN1physical
28514442
RPC5_HUMANPOLR3Ephysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00068 Anhydrous ethanol (JP16); Alcohol (USP); Dehydrated ethanol; Ethyl alcohol; Dehydrated ethanol (TN)
D00131 Disulfiram (JP16/USP/INN); Antabuse (TN)
D00217 Acetaminophen (JP16/USP); Paracetamol (INN); Tylenol (TN)
D00255 Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00346 Isoniazid (JP16/USP/INN); Laniazid (TN)
D00371 Theophylline (JP16); Elixophyllin (TN); Quibron-t (TN); Theo-24 (TN); Theodur G (TN); Theolair (TN);
D00528 Anhydrous caffeine (JP16); Caffeine (USP); Anhydrous caffeine (TN)
D00539 Ethosuximide (JP16/USP/INN); Zarontin (TN)
D00542 Halothane (JP16/USP/INN); Fluothane (TN)
D00543 Enflurane (JP16/USP/INN); Ethrane (TN)
D00544 Methoxyflurane (USP/INN); Penthrane (TN)
D00545 Isoflurane (JP16/USP/INN); Forane (TN)
D00547 Sevoflurane (JP16/USAN/INN); Ultane (TN)
D00592 Diaphenylsulfone (JAN); Dapsone (USP); Aczone (TN)
D00674 Naratriptan hydrochloride (JAN/USAN); Amerge (TN)
D00771 Chlorzoxazone (JAN/USP/INN); Paraflex (TN)
D00899 Nelfinavir mesilate (JAN); Nelfinavir mesylate (USAN/INN); Viracept (TN)
D01453 Caffeine hydrate (JP16); Caffeine monohydrate; Caffeine (TN)
D01501 Isoniazid calcium pyruvinate (JAN); Pyruvic acid calcium isoniazid
D01772 Ether (JP16/USP); Diethyl ether
D02311 Acetone (NF); 2-Propanone; Acetone (TN)
D03415 Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D06103 Theophylline (USP); Theophylline monohydrate; Accurbron (TN)
D06542 Ethanol (JP16); Ethanol (TN)
D08255 Naratriptan (INN); Naramig (TN)
D08259 Nelfinavir (INN); Viracept (TN)
DrugBank
DB00316Acetaminophen
DB00041Aldesleukin
DB00918Almotriptan
DB00969Alosetron
DB01223Aminophylline
DB00321Amitriptyline
DB01435Antipyrine
DB00972Azelastine
DB06770Benzyl alcohol
DB04794Bifonazole
DB01558Bromazepam
DB00835Brompheniramine
DB01156Bupropion
DB00201Caffeine
DB00748Carbinoxamine
DB01136Carvedilol
DB00477Chlorpromazine
DB00356Chlorzoxazone
DB00501Cimetidine
DB00215Citalopram
DB04920Clevidipine
DB00636Clofibrate
DB00882Clomifene
DB01068Clonazepam
DB00257Clotrimazole
DB00363Clozapine
DB01394Colchicine
DB00851Dacarbazine
DB06637Dalfampridine
DB00250Dapsone
DB01151Desipramine
DB01234Dexamethasone
DB01191Dexfenfluramine
DB00633Dexmedetomidine
DB00514Dextromethorphan
DB00829Diazepam
DB00586Diclofenac
DB00255Diethylstilbestrol
DB00822Disulfiram
DB01127Econazole
DB00228Enflurane
DB00109Enfuvirtide
DB00655Estrone
DB00898Ethanol
DB06689Ethanolamine Oleate
DB00593Ethosuximide
DB00773Etoposide
DB01628Etoricoxib
DB00949Felbamate
DB08868Fingolimod
DB01544Flunitrazepam
DB00623Fluphenazine
DB00690Flurazepam
DB00176Fluvoxamine
DB00158Folic Acid
DB01213Fomepizole
DB01296Glucosamine
DB01159Halothane
DB01355Hexobarbital
DB04946Iloperidone
DB00458Imipramine
DB00753Isoflurane
DB00951Isoniazid
DB00883Isosorbide Dinitrate
DB01167Itraconazole
DB00170Menadione
DB00371Meprobamate
DB00703Methazolamide
DB00763Methimazole
DB01403Methotrimeprazine
DB01028Methoxyflurane
DB01011Metyrapone
DB00379Mexiletine
DB01110Miconazole
DB00683Midazolam
DB01204Mitoxantrone
DB00622Nicardipine
DB00184Nicotine
DB01115Nifedipine
DB06712Nilvadipine
DB01595Nitrazepam
DB00540Nortriptyline
DB00904Ondansetron
DB01173Orphenadrine
DB00526Oxaliplatin
DB00617Paramethadione
DB00780Phenelzine
DB01174Phenobarbital
DB01085Pilocarpine
DB01100Pimozide
DB01131Proguanil
DB00818Propofol
DB00908Quinidine
DB00468Quinine
DB01045Rifampicin
DB00503Ritonavir
DB06201Rufinamide
DB00118S-Adenosylmethionine
DB01037Selegiline
DB01236Sevoflurane
DB00203Sildenafil
DB00428Streptozocin
DB00359Sulfadiazine
DB00259Sulfanilamide
DB00675Tamoxifen
DB01041Thalidomide
DB01412Theobromine
DB00277Theophylline
DB00599Thiopental
DB00679Thioridazine
DB00208Ticlopidine
DB01007Tioconazole
DB05109Trabectedin
DB00752Tranylcypromine
DB00347Trimethadione
DB01586Ursodeoxycholic acid
DB00549Zafirlukast
DB01198Zopiclone
Regulatory Network of CP2E1_HUMAN

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Related Literatures of Post-Translational Modification

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