MAFG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAFG_HUMAN
• UniProt AC: O15525
• Protein Name: Transcription factor MafG
• Gene Name: MAFG
• Organism: Homo sapiens (Human).
• Sequence Length: 162
• Subcellular Localization: Nucleus .
• Protein Description: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. [PubMed: 11154691 However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites]
• Protein Sequence: MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MTTPNKGNKALKV --CCCCCCCCCCEEE	66.13	25953088
9	Acetylation	TTPNKGNKALKVKRE CCCCCCCCCEEEECC	64.86	25953088
14	Sumoylation	GNKALKVKREPGENG CCCCEEEECCCCCCC	49.83	-
14	Sumoylation	GNKALKVKREPGENG CCCCEEEECCCCCCC	49.83	28112733
14	Acetylation	GNKALKVKREPGENG CCCCEEEECCCCCCC	49.83	26051181
23	Phosphorylation	EPGENGTSLTDEELV CCCCCCCCCCHHHHH	30.58	22210691
33	Phosphorylation	DEELVTMSVRELNQH HHHHHHHHHHHHHHH	14.52	22210691
46	Ubiquitination	QHLRGLSKEEIVQLK HHHCCCCHHHHHHHH	65.49	-
53	Acetylation	KEEIVQLKQRRRTLK HHHHHHHHHHHHHHH	25.35	11154691
53	Ubiquitination	KEEIVQLKQRRRTLK HHHHHHHHHHHHHHH	25.35	11154691
60	Acetylation	KQRRRTLKNRGYAAS HHHHHHHHHCHHHHH	43.94	11154691
71	Acetylation	YAASCRVKRVTQKEE HHHHHHEEECCCHHH	23.07	11154691
76	Acetylation	RVKRVTQKEELEKQK HEEECCCHHHHHHHH	43.73	11154691
83	Ubiquitination	KEELEKQKAELQQEV HHHHHHHHHHHHHHH	55.70	-
101	Acetylation	ASENASMKLELDALR HHCCHHHHHHHHHHH	35.99	7673907
110	Ubiquitination	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	21890473
110	Sumoylation	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	-
110	Sumoylation	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	-
110	Acetylation	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	26051181
111	Phosphorylation	LDALRSKYEALQTFA HHHHHHHHHHHHHHH	14.00	-
120	Phosphorylation	ALQTFARTVARSPVA HHHHHHHHHHCCCCC	18.32	24732914
124	Phosphorylation	FARTVARSPVAPARG HHHHHHCCCCCCCCC	17.62	25218447
155	Sumoylation	TSVITIVKSKTDARS EEEEEEEECCCCCCC	42.24	-
155	Sumoylation	TSVITIVKSKTDARS EEEEEEEECCCCCCC	42.24	-
156	Phosphorylation	SVITIVKSKTDARS- EEEEEEECCCCCCC-	29.87	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
124	S	Phosphorylation	Kinase	ERK1	P27361	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
14	K	Sumoylation	Sumoylation at Lys-14 is required for active transcriptional repression.	25218447

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAFG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED31_HUMAN	MED31	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
VIME_HUMAN	VIM	physical	16169070
CHD3_HUMAN	CHD3	physical	16169070
NF2L1_HUMAN	NFE2L1	physical	8932385
NFE2_HUMAN	NFE2	physical	9166829
MAFG_HUMAN	MAFG	physical	9166829
TF2AY_HUMAN	GTF2A1L	physical	20211142
BACH2_HUMAN	BACH2	physical	23661758
BACH1_HUMAN	BACH1	physical	23661758
NF2L2_HUMAN	NFE2L2	physical	23661758
MAFG_HUMAN	MAFG	physical	23661758
MAFF_HUMAN	MAFF	physical	23661758
BATF3_HUMAN	BATF3	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
NFIL3_HUMAN	NFIL3	physical	23661758
NF2L2_HUMAN	NFE2L2	physical	21988832
RSMN_HUMAN	SNRPN	physical	21988832
PARP1_HUMAN	PARP1	physical	24140708
NF2L2_HUMAN	NFE2L2	physical	24140708
NF2L2_HUMAN	NFE2L2	physical	23737527

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.