BATF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BATF3_HUMAN
• UniProt AC: Q9NR55
• Protein Name: Basic leucine zipper transcriptional factor ATF-like 3
• Gene Name: BATF3
• Organism: Homo sapiens (Human).
• Sequence Length: 127
• Subcellular Localization: Nucleus .
• Protein Description: AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes..
• Protein Sequence: MSQGLPAAGSVLQRSVAAPGNQPQPQPQQQSPEDDDRKVRRREKNRVAAQRSRKKQTQKADKLHEEYESLEQENTMLRREIGKLTEELKHLTEALKEHEKMCPLLLCPMNFVPVPPRPDPVAGCLPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQGLPAAG ------CCCCCCCCH	32.71	20164059
10	Phosphorylation	QGLPAAGSVLQRSVA CCCCCCHHHHHHHCC	18.22	29457462
31	Phosphorylation	QPQPQQQSPEDDDRK CCCCCCCCCCCCHHH	26.39	23401153
57	Phosphorylation	QRSRKKQTQKADKLH HHHHHHHHHHHHHHH	40.70	25690035
67	Phosphorylation	ADKLHEEYESLEQEN HHHHHHHHHHHHHHH	14.08	26552605
69	Phosphorylation	KLHEEYESLEQENTM HHHHHHHHHHHHHHH	35.98	26552605
75	Phosphorylation	ESLEQENTMLRREIG HHHHHHHHHHHHHHH	19.48	26552605
83	Ubiquitination	MLRREIGKLTEELKH HHHHHHHHHHHHHHH	58.87	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BATF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BATF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BATF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NF2IP_HUMAN	NFATC2IP	physical	10878360
JUN_HUMAN	JUN	physical	10878360
BACH2_HUMAN	BACH2	physical	23661758
MAFG_HUMAN	MAFG	physical	23661758
MAFF_HUMAN	MAFF	physical	23661758
BATF3_HUMAN	BATF3	physical	23661758
BATF_HUMAN	BATF	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
JUNB_HUMAN	JUNB	physical	23661758
ATF2_HUMAN	ATF2	physical	23661758
JUN_HUMAN	JUN	physical	23661758
DBP_HUMAN	DBP	physical	23661758
CEBPE_HUMAN	CEBPE	physical	23661758
CEBPA_HUMAN	CEBPA	physical	23661758
CEBPG_HUMAN	CEBPG	physical	23661758
JUNB_HUMAN	JUNB	physical	28514442
BACH2_HUMAN	BACH2	physical	28514442
ATF7_HUMAN	ATF7	physical	28514442
RTL6_HUMAN	LDOC1L	physical	28514442
ZN451_HUMAN	ZNF451	physical	28514442
JUND_HUMAN	JUND	physical	28514442
ATF2_HUMAN	ATF2	physical	28514442
BACH1_HUMAN	BACH1	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
JUN_HUMAN	JUN	physical	28514442
USF1_HUMAN	USF1	physical	28514442
CREB5_HUMAN	CREB5	physical	28514442
SYTC2_HUMAN	TARSL2	physical	28514442
GOPC_HUMAN	GOPC	physical	28514442
TLK1_HUMAN	TLK1	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
NRDC_HUMAN	NRD1	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
UB2R2_HUMAN	UBE2R2	physical	28514442
NPTX2_HUMAN	NPTX2	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
EF1D_HUMAN	EEF1D	physical	28514442
SYCC_HUMAN	CARS	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 19413330