NPTX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPTX2_HUMAN
• UniProt AC: P47972
• Protein Name: Neuronal pentraxin-2
• Gene Name: NPTX2
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Secreted.
• Protein Description: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity)..
• Protein Sequence: MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	VAAGAQDSPAPGSRF HHHCCCCCCCCCCCE	15.75	22496350
25	Phosphorylation	QDSPAPGSRFVCTAL CCCCCCCCCEEEEEC	22.83	24300666
108	Phosphorylation	KARGAGATGKDTMGD CCCCCCCCCCCCCCC	43.79	23312004
148	N-linked_Glycosylation	LEHQLRANVSNAGLP HHHHHHHCHHCCCCC	31.17	UniProtKB CARBOHYD
189	N-linked_Glycosylation	DEKSLLHNETSAHRQ HHHHHHCCCCHHHHH	54.96	UniProtKB CARBOHYD
198	Phosphorylation	TSAHRQKTESTLNAL CHHHHHHHHHHHHHH	27.16	29978859
200	Phosphorylation	AHRQKTESTLNALLQ HHHHHHHHHHHHHHH	43.35	29978859
201	Phosphorylation	HRQKTESTLNALLQR HHHHHHHHHHHHHHH	20.14	29978859
221	Phosphorylation	RGNSAFKSPDAFKVS CCCCCCCCCCCEEEE	22.89	24144214
228	Phosphorylation	SPDAFKVSLPLRTNY CCCCEEEECCCCCHH	25.51	24719451
233	Phosphorylation	KVSLPLRTNYLYGKI EEECCCCCHHHHHHH	35.58	24144214
235	Phosphorylation	SLPLRTNYLYGKIKK ECCCCCHHHHHHHHH	10.73	24144214
237	Phosphorylation	PLRTNYLYGKIKKTL CCCCHHHHHHHHHHH	13.15	24144214
393	N-linked_Glycosylation	QEIVNIANCSTNMPG HHHHHHHCCCCCCCC	19.24	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPTX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPTX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPTX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPTX1_RAT	Nptx1	physical	10748068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.