| UniProt ID | ZN451_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y4E5 | |
| Protein Name | E3 SUMO-protein ligase ZNF451 {ECO:0000303|PubMed:26524494} | |
| Gene Name | ZNF451 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1061 | |
| Subcellular Localization |
Nucleus . Nucleus, PML body . Nucleus, nucleoplasm. Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. |
|
| Protein Description | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. [PubMed: 26524493] | |
| Protein Sequence | MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPLRPVLEYIDLVSSDDEEPSTSYTDENIKRKDHIDYQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINCGTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQQYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDETSTQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAHLNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANSSPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLIFNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGKLWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGSEKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | PLRPVLEYIDLVSSD CCCCCEEEEEECCCC | 8.79 | 27732954 | |
| 50 | Phosphorylation | LEYIDLVSSDDEEPS EEEEEECCCCCCCCC | 35.03 | 20873877 | |
| 51 | Phosphorylation | EYIDLVSSDDEEPST EEEEECCCCCCCCCC | 41.42 | 20873877 | |
| 57 | Phosphorylation | SSDDEEPSTSYTDEN CCCCCCCCCCCCCCC | 33.01 | 27732954 | |
| 58 | Phosphorylation | SDDEEPSTSYTDENI CCCCCCCCCCCCCCC | 36.15 | 27732954 | |
| 59 | Phosphorylation | DDEEPSTSYTDENIK CCCCCCCCCCCCCCC | 30.30 | 27732954 | |
| 60 | Phosphorylation | DEEPSTSYTDENIKR CCCCCCCCCCCCCCC | 20.49 | 27732954 | |
| 61 | Phosphorylation | EEPSTSYTDENIKRK CCCCCCCCCCCCCCC | 36.28 | 27732954 | |
| 68 | Ubiquitination | TDENIKRKDHIDYQK CCCCCCCCCCCCHHH | 48.97 | - | |
| 75 | Sumoylation | KDHIDYQKDKVALTL CCCCCHHHHHHHHHH | 53.97 | - | |
| 75 | Ubiquitination | KDHIDYQKDKVALTL CCCCCHHHHHHHHHH | 53.97 | 21906983 | |
| 75 | Sumoylation | KDHIDYQKDKVALTL CCCCCHHHHHHHHHH | 53.97 | 28112733 | |
| 75 (in isoform 1) | Ubiquitination | - | 53.97 | 21890473 | |
| 75 (in isoform 2) | Ubiquitination | - | 53.97 | 21890473 | |
| 77 | Sumoylation | HIDYQKDKVALTLAR CCCHHHHHHHHHHHH | 36.12 | - | |
| 77 | Ubiquitination | HIDYQKDKVALTLAR CCCHHHHHHHHHHHH | 36.12 | - | |
| 77 | Sumoylation | HIDYQKDKVALTLAR CCCHHHHHHHHHHHH | 36.12 | 28112733 | |
| 77 | Acetylation | HIDYQKDKVALTLAR CCCHHHHHHHHHHHH | 36.12 | 25953088 | |
| 81 | Phosphorylation | QKDKVALTLARLARH HHHHHHHHHHHHHHH | 14.50 | 24719451 | |
| 93 | Ubiquitination | ARHVEVEKQQKEEKN HHHHHHHHHHHHHHH | 64.30 | - | |
| 96 (in isoform 4) | Phosphorylation | - | 66.40 | 28348404 | |
| 98 (in isoform 4) | Phosphorylation | - | 63.77 | 28348404 | |
| 100 (in isoform 4) | Phosphorylation | - | 43.74 | 28348404 | |
| 101 (in isoform 4) | Phosphorylation | - | 46.28 | 28348404 | |
| 102 (in isoform 4) | Phosphorylation | - | 19.76 | 28348404 | |
| 106 | Sumoylation | KNRAFREKIDFQHAH HHHHHHHHCCHHHHC | 43.23 | - | |
| 106 | Ubiquitination | KNRAFREKIDFQHAH HHHHHHHHCCHHHHC | 43.23 | 21890473 | |
| 106 | Sumoylation | KNRAFREKIDFQHAH HHHHHHHHCCHHHHC | 43.23 | 28112733 | |
| 106 (in isoform 2) | Ubiquitination | - | 43.23 | 21890473 | |
| 106 (in isoform 1) | Ubiquitination | - | 43.23 | 21890473 | |
| 108 (in isoform 4) | Phosphorylation | - | 48.50 | - | |
| 111 (in isoform 4) | Phosphorylation | - | 21.49 | 27135362 | |
| 112 (in isoform 4) | Phosphorylation | - | 6.40 | 27135362 | |
| 121 (in isoform 4) | Ubiquitination | - | 3.63 | 21906983 | |
| 127 | Phosphorylation | FIRGHSDTEAARLCV ECCCCCCHHHHHHHH | 30.45 | - | |
| 130 (in isoform 4) | Ubiquitination | - | 9.95 | 21906983 | |
| 138 (in isoform 4) | Ubiquitination | - | 2.57 | 21906983 | |
| 139 | Sumoylation | LCVDQWLKMPGLKTG HHHHHHHCCCCCCCE | 39.84 | - | |
| 139 | Ubiquitination | LCVDQWLKMPGLKTG HHHHHHHCCCCCCCE | 39.84 | - | |
| 139 | Sumoylation | LCVDQWLKMPGLKTG HHHHHHHCCCCCCCE | 39.84 | 28112733 | |
| 144 | Sumoylation | WLKMPGLKTGTINCG HHCCCCCCCEEEECC | 51.31 | - | |
| 144 | Ubiquitination | WLKMPGLKTGTINCG HHCCCCCCCEEEECC | 51.31 | - | |
| 144 | Sumoylation | WLKMPGLKTGTINCG HHCCCCCCCEEEECC | 51.31 | 28112733 | |
| 145 | Phosphorylation | LKMPGLKTGTINCGT HCCCCCCCEEEECCC | 44.60 | 24719451 | |
| 147 | Phosphorylation | MPGLKTGTINCGTKS CCCCCCEEEECCCCC | 17.78 | 26434776 | |
| 148 (in isoform 4) | Phosphorylation | - | 4.20 | 26657352 | |
| 149 (in isoform 4) | Phosphorylation | - | 20.29 | 27050516 | |
| 152 | Phosphorylation | TGTINCGTKSSFRRG CEEEECCCCCCCCCC | 29.92 | 26434776 | |
| 153 | Sumoylation | GTINCGTKSSFRRGG EEEECCCCCCCCCCC | 29.41 | - | |
| 153 | Ubiquitination | GTINCGTKSSFRRGG EEEECCCCCCCCCCC | 29.41 | - | |
| 153 | Sumoylation | GTINCGTKSSFRRGG EEEECCCCCCCCCCC | 29.41 | 28112733 | |
| 154 | Phosphorylation | TINCGTKSSFRRGGH EEECCCCCCCCCCCE | 34.25 | 26434776 | |
| 155 | Phosphorylation | INCGTKSSFRRGGHT EECCCCCCCCCCCEE | 25.07 | 26434776 | |
| 158 | Methylation | GTKSSFRRGGHTWVS CCCCCCCCCCEEEEC | 54.13 | 24129315 | |
| 164 (in isoform 4) | Ubiquitination | - | 5.93 | 21906983 | |
| 167 | Ubiquitination | GHTWVSGKPILCPIM CEEEECCCEEEECEE | 22.75 | - | |
| 167 | Sumoylation | GHTWVSGKPILCPIM CEEEECCCEEEECEE | 22.75 | 28112733 | |
| 171 (in isoform 4) | Phosphorylation | - | 1.91 | 30631047 | |
| 172 (in isoform 4) | Phosphorylation | - | 24.40 | - | |
| 173 (in isoform 4) | Phosphorylation | - | 2.62 | 30631047 | |
| 175 (in isoform 4) | Phosphorylation | - | 16.84 | - | |
| 191 | Ubiquitination | HLLLGHLKRFDHSPC CEEEHHHHHCCCCCC | 45.40 | - | |
| 220 | Sumoylation | ACVVCYKKFVTQQQY EEEHHHHHCCCHHHH | 20.70 | - | |
| 220 | Sumoylation | ACVVCYKKFVTQQQY EEEHHHHHCCCHHHH | 20.70 | - | |
| 220 | Ubiquitination | ACVVCYKKFVTQQQY EEEHHHHHCCCHHHH | 20.70 | - | |
| 231 (in isoform 4) | Phosphorylation | - | 7.51 | 25159151 | |
| 240 (in isoform 4) | Ubiquitination | - | 28.38 | 21906983 | |
| 241 (in isoform 4) | Phosphorylation | - | 40.62 | 25849741 | |
| 247 (in isoform 4) | Ubiquitination | - | 26.87 | 21906983 | |
| 270 | Sumoylation | SRKEECSKHMSGKNH ECHHHHHHHCCCCCC | 55.79 | 28112733 | |
| 275 | Acetylation | CSKHMSGKNHFHQSF HHHHCCCCCCCCCCE | 39.69 | 7962855 | |
| 275 | Sumoylation | CSKHMSGKNHFHQSF HHHHCCCCCCCCCCE | 39.69 | - | |
| 275 | Sumoylation | CSKHMSGKNHFHQSF HHHHCCCCCCCCCCE | 39.69 | 28112733 | |
| 275 | Ubiquitination | CSKHMSGKNHFHQSF HHHHCCCCCCCCCCE | 39.69 | - | |
| 283 | Acetylation | NHFHQSFKLGDNKGI CCCCCCEECCCCCCC | 57.73 | 7962865 | |
| 283 | Sumoylation | NHFHQSFKLGDNKGI CCCCCCEECCCCCCC | 57.73 | - | |
| 283 | Ubiquitination | NHFHQSFKLGDNKGI CCCCCCEECCCCCCC | 57.73 | - | |
| 283 | Sumoylation | NHFHQSFKLGDNKGI CCCCCCEECCCCCCC | 57.73 | 28112733 | |
| 286 (in isoform 4) | Ubiquitination | - | 65.19 | - | |
| 288 | Sumoylation | SFKLGDNKGIAHPIS CEECCCCCCCCCCCC | 57.33 | - | |
| 288 | Ubiquitination | SFKLGDNKGIAHPIS CEECCCCCCCCCCCC | 57.33 | 21906983 | |
| 288 | Sumoylation | SFKLGDNKGIAHPIS CEECCCCCCCCCCCC | 57.33 | 28112733 | |
| 288 (in isoform 2) | Ubiquitination | - | 57.33 | 21890473 | |
| 288 (in isoform 1) | Ubiquitination | - | 57.33 | 21890473 | |
| 293 (in isoform 4) | Ubiquitination | - | 18.20 | - | |
| 294 (in isoform 4) | Ubiquitination | - | 4.81 | - | |
| 301 | Ubiquitination | ISFPSFAKKLLISLC CCCHHHHHHHHHHHH | 41.78 | - | |
| 301 | Sumoylation | ISFPSFAKKLLISLC CCCHHHHHHHHHHHH | 41.78 | 28112733 | |
| 302 | Sumoylation | SFPSFAKKLLISLCK CCHHHHHHHHHHHHC | 45.13 | - | |
| 302 | Sumoylation | SFPSFAKKLLISLCK CCHHHHHHHHHHHHC | 45.13 | - | |
| 302 | Ubiquitination | SFPSFAKKLLISLCK CCHHHHHHHHHHHHC | 45.13 | - | |
| 308 (in isoform 4) | Phosphorylation | - | 2.56 | 24114839 | |
| 309 | Ubiquitination | KLLISLCKDVPFQVK HHHHHHHCCCCCEEE | 68.03 | - | |
| 309 | Sumoylation | KLLISLCKDVPFQVK HHHHHHHCCCCCEEE | 68.03 | 28112733 | |
| 313 (in isoform 4) | Ubiquitination | - | 15.21 | - | |
| 316 | Sumoylation | KDVPFQVKCVACHKT CCCCCEEEEECCCHH | 16.53 | - | |
| 316 | Ubiquitination | KDVPFQVKCVACHKT CCCCCEEEEECCCHH | 16.53 | 21890473 | |
| 316 | Sumoylation | KDVPFQVKCVACHKT CCCCCEEEEECCCHH | 16.53 | - | |
| 316 | Acetylation | KDVPFQVKCVACHKT CCCCCEEEEECCCHH | 16.53 | 25953088 | |
| 316 (in isoform 1) | Ubiquitination | - | 16.53 | 21890473 | |
| 316 (in isoform 2) | Ubiquitination | - | 16.53 | 21890473 | |
| 333 (in isoform 4) | Ubiquitination | - | 13.05 | 21906983 | |
| 349 | Ubiquitination | GPVAVAEKSITQVAE CCEEEEEHHHHHHHH | 37.10 | 21906983 | |
| 349 (in isoform 1) | Ubiquitination | - | 37.10 | 21890473 | |
| 349 (in isoform 2) | Ubiquitination | - | 37.10 | 21890473 | |
| 356 (in isoform 4) | Ubiquitination | - | 50.04 | 21906983 | |
| 357 | Sumoylation | SITQVAEKFILRGYC HHHHHHHHHHHCCCC | 28.15 | - | |
| 357 | Ubiquitination | SITQVAEKFILRGYC HHHHHHHHHHHCCCC | 28.15 | 21890473 | |
| 357 | Sumoylation | SITQVAEKFILRGYC HHHHHHHHHHHCCCC | 28.15 | 28112733 | |
| 357 (in isoform 1) | Ubiquitination | - | 28.15 | 21890473 | |
| 357 (in isoform 2) | Ubiquitination | - | 28.15 | 21890473 | |
| 360 (in isoform 4) | Phosphorylation | - | 3.80 | 25159151 | |
| 361 (in isoform 4) | Phosphorylation | - | 29.26 | 25159151 | |
| 362 (in isoform 4) | Phosphorylation | - | 25.58 | 25159151 | |
| 369 (in isoform 4) | Ubiquitination | - | 36.04 | - | |
| 381 | Ubiquitination | ETSTQNHKQNSGHKV CCCCCCCCCCCCCCE | 59.74 | - | |
| 387 | Ubiquitination | HKQNSGHKVRVINSV CCCCCCCCEEEECCC | 34.95 | - | |
| 401 (in isoform 4) | Ubiquitination | - | 5.51 | - | |
| 409 | Ubiquitination | CHSSEGNKDPSSDLH EECCCCCCCCCCCHH | 80.17 | - | |
| 423 | Sumoylation | HLLLDQSKFSSLKRT HHHHCHHHHHHCHHC | 43.57 | - | |
| 423 | Ubiquitination | HLLLDQSKFSSLKRT HHHHCHHHHHHCHHC | 43.57 | 21890473 | |
| 423 | Sumoylation | HLLLDQSKFSSLKRT HHHHCHHHHHHCHHC | 43.57 | 28112733 | |
| 423 (in isoform 1) | Ubiquitination | - | 43.57 | 21890473 | |
| 423 (in isoform 2) | Ubiquitination | - | 43.57 | 21890473 | |
| 428 | Sumoylation | QSKFSSLKRTMSIKE HHHHHHCHHCCCCCC | 48.01 | - | |
| 428 | Sumoylation | QSKFSSLKRTMSIKE HHHHHHCHHCCCCCC | 48.01 | - | |
| 430 | Phosphorylation | KFSSLKRTMSIKESS HHHHCHHCCCCCCCC | 17.43 | 29116813 | |
| 432 | Phosphorylation | SSLKRTMSIKESSSL HHCHHCCCCCCCCCC | 29.87 | 25218447 | |
| 434 | Sumoylation | LKRTMSIKESSSLEC CHHCCCCCCCCCCEE | 44.21 | - | |
| 434 | Ubiquitination | LKRTMSIKESSSLEC CHHCCCCCCCCCCEE | 44.21 | - | |
| 434 | Sumoylation | LKRTMSIKESSSLEC CHHCCCCCCCCCCEE | 44.21 | 28112733 | |
| 436 | Phosphorylation | RTMSIKESSSLECIA HCCCCCCCCCCEEEE | 21.89 | 26434776 | |
| 437 | Phosphorylation | TMSIKESSSLECIAI CCCCCCCCCCEEEEE | 39.78 | 26434776 | |
| 438 | Phosphorylation | MSIKESSSLECIAIP CCCCCCCCCEEEEEE | 37.15 | 30622161 | |
| 446 | Sumoylation | LECIAIPKKKMNLKD CEEEEEECCCCCCCC | 59.94 | - | |
| 446 | Sumoylation | LECIAIPKKKMNLKD CEEEEEECCCCCCCC | 59.94 | 28112733 | |
| 446 | Ubiquitination | LECIAIPKKKMNLKD CEEEEEECCCCCCCC | 59.94 | - | |
| 448 | Ubiquitination | CIAIPKKKMNLKDKS EEEEECCCCCCCCCC | 38.86 | - | |
| 452 | Sumoylation | PKKKMNLKDKSHEGV ECCCCCCCCCCCCCE | 59.09 | - | |
| 452 | Sumoylation | PKKKMNLKDKSHEGV ECCCCCCCCCCCCCE | 59.09 | 28112733 | |
| 452 | Ubiquitination | PKKKMNLKDKSHEGV ECCCCCCCCCCCCCE | 59.09 | - | |
| 454 | Sumoylation | KKMNLKDKSHEGVAC CCCCCCCCCCCCEEE | 52.72 | - | |
| 454 | Ubiquitination | KKMNLKDKSHEGVAC CCCCCCCCCCCCEEE | 52.72 | 21906983 | |
| 454 | Sumoylation | KKMNLKDKSHEGVAC CCCCCCCCCCCCEEE | 52.72 | 28112733 | |
| 454 (in isoform 1) | Ubiquitination | - | 52.72 | 21890473 | |
| 454 (in isoform 2) | Ubiquitination | - | 52.72 | 21890473 | |
| 464 | Sumoylation | EGVACVQKEKSVVKT CCEEECCCCCHHEEE | 46.87 | - | |
| 464 | Ubiquitination | EGVACVQKEKSVVKT CCEEECCCCCHHEEE | 46.87 | 21906983 | |
| 464 | Sumoylation | EGVACVQKEKSVVKT CCEEECCCCCHHEEE | 46.87 | 28112733 | |
| 464 (in isoform 4) | Phosphorylation | - | 46.87 | 30266825 | |
| 464 (in isoform 1) | Ubiquitination | - | 46.87 | 21890473 | |
| 464 (in isoform 2) | Ubiquitination | - | 46.87 | 21890473 | |
| 465 (in isoform 4) | Phosphorylation | - | 33.21 | 30266825 | |
| 467 (in isoform 4) | Phosphorylation | - | 32.98 | 30266825 | |
| 470 | Ubiquitination | QKEKSVVKTWFCECN CCCCHHEEEEEEECC | 37.57 | - | |
| 473 (in isoform 4) | Ubiquitination | - | 2.81 | - | |
| 488 | Ubiquitination | PSEDAVEKHVFSANT CCHHHHHHHCCCCCC | 38.17 | - | |
| 490 (in isoform 4) | Ubiquitination | - | 6.33 | 21906983 | |
| 499 | Sumoylation | SANTMGYKCVVCGKV CCCCCCCEEEEECCE | 18.15 | - | |
| 499 | Sumoylation | SANTMGYKCVVCGKV CCCCCCCEEEEECCE | 18.15 | - | |
| 500 (in isoform 4) | Ubiquitination | - | 1.77 | 21906983 | |
| 505 | Ubiquitination | YKCVVCGKVCDDSGV CEEEEECCEECCCCC | 34.27 | - | |
| 505 (in isoform 4) | Ubiquitination | - | 34.27 | - | |
| 522 (in isoform 4) | Ubiquitination | - | 32.39 | - | |
| 532 (in isoform 4) | Ubiquitination | - | 3.47 | - | |
| 537 (in isoform 4) | Ubiquitination | - | 48.98 | - | |
| 543 | Sumoylation | CKKELTRKDTIMAHV CCHHHCCCCCEEHHE | 54.72 | - | |
| 543 | Sumoylation | CKKELTRKDTIMAHV CCHHHCCCCCEEHHE | 54.72 | 28112733 | |
| 551 | Phosphorylation | DTIMAHVTEFHNGHR CCEEHHEEEEECCEE | 24.06 | 19690332 | |
| 551 (in isoform 4) | Phosphorylation | - | 24.06 | 24719451 | |
| 557 (in isoform 4) | Phosphorylation | - | 26.95 | - | |
| 559 | Phosphorylation | EFHNGHRYFYEMDEV EEECCEEEEEEECEE | 12.58 | 27251275 | |
| 561 | Phosphorylation | HNGHRYFYEMDEVEG ECCEEEEEEECEECC | 11.04 | 27251275 | |
| 570 | Phosphorylation | MDEVEGETLPSSSTT ECEECCEECCCCCCC | 55.62 | 27251275 | |
| 573 | Phosphorylation | VEGETLPSSSTTLDN ECCEECCCCCCCHHH | 39.78 | 27251275 | |
| 574 | Phosphorylation | EGETLPSSSTTLDNL CCEECCCCCCCHHHC | 29.75 | 27251275 | |
| 575 | Phosphorylation | GETLPSSSTTLDNLT CEECCCCCCCHHHCC | 29.74 | 27251275 | |
| 576 | Phosphorylation | ETLPSSSTTLDNLTA EECCCCCCCHHHCCC | 33.07 | 27251275 | |
| 577 | Phosphorylation | TLPSSSTTLDNLTAN ECCCCCCCHHHCCCC | 33.78 | 27251275 | |
| 582 | Phosphorylation | STTLDNLTANKPSSA CCCHHHCCCCCCCCC | 34.14 | 27251275 | |
| 585 | Ubiquitination | LDNLTANKPSSAITV HHHCCCCCCCCCEEE | 43.76 | 21906983 | |
| 585 (in isoform 2) | Ubiquitination | - | 43.76 | 21890473 | |
| 585 | Sumoylation | LDNLTANKPSSAITV HHHCCCCCCCCCEEE | 43.76 | 28112733 | |
| 585 (in isoform 1) | Ubiquitination | - | 43.76 | 21890473 | |
| 587 | Phosphorylation | NLTANKPSSAITVID HCCCCCCCCCEEEEE | 33.73 | 27251275 | |
| 588 | Phosphorylation | LTANKPSSAITVIDH CCCCCCCCCEEEEEC | 32.02 | 27251275 | |
| 591 | Phosphorylation | NKPSSAITVIDHSPA CCCCCCEEEEECCCC | 15.89 | 26074081 | |
| 596 | Phosphorylation | AITVIDHSPANSSPR CEEEEECCCCCCCCC | 23.20 | 25159151 | |
| 600 | Phosphorylation | IDHSPANSSPRGKWQ EECCCCCCCCCCCCE | 43.77 | 25849741 | |
| 601 | Phosphorylation | DHSPANSSPRGKWQC ECCCCCCCCCCCCEE | 20.58 | 25849741 | |
| 605 | Sumoylation | ANSSPRGKWQCRICE CCCCCCCCCEEEECH | 35.06 | - | |
| 605 | Sumoylation | ANSSPRGKWQCRICE CCCCCCCCCEEEECH | 35.06 | - | |
| 622 | Ubiquitination | FDSQEYVKQHCMSLA CCCHHHHHHHHHHHH | 33.16 | - | |
| 632 | Sumoylation | CMSLASHKFHRYSCA HHHHHHHHHHHCCCH | 40.13 | - | |
| 632 | Sumoylation | CMSLASHKFHRYSCA HHHHHHHHHHHCCCH | 40.13 | 28112733 | |
| 632 | Ubiquitination | CMSLASHKFHRYSCA HHHHHHHHHHHCCCH | 40.13 | - | |
| 647 | Sumoylation | HCRKPFHKIETLYRH HCCCCHHHHHHHHHH | 42.49 | - | |
| 647 | Sumoylation | HCRKPFHKIETLYRH HCCCCHHHHHHHHHH | 42.49 | 28112733 | |
| 647 | Ubiquitination | HCRKPFHKIETLYRH HCCCCHHHHHHHHHH | 42.49 | - | |
| 664 | Sumoylation | DEHDNEIKIKYFCGL CCCCCCEEHHHHHHH | 27.28 | - | |
| 664 | Ubiquitination | DEHDNEIKIKYFCGL CCCCCCEEHHHHHHH | 27.28 | - | |
| 664 | Sumoylation | DEHDNEIKIKYFCGL CCCCCCEEHHHHHHH | 27.28 | 28112733 | |
| 706 | Sumoylation | EKTETSIKTEDDFPV CCCCCCCCCCCCCCE | 45.70 | - | |
| 706 | Ubiquitination | EKTETSIKTEDDFPV CCCCCCCCCCCCCCE | 45.70 | 21906983 | |
| 706 | Sumoylation | EKTETSIKTEDDFPV CCCCCCCCCCCCCCE | 45.70 | 25114211 | |
| 706 (in isoform 1) | Ubiquitination | - | 45.70 | 21890473 | |
| 706 (in isoform 2) | Ubiquitination | - | 45.70 | 21890473 | |
| 731 | Sumoylation | CRESYICKVNRKEDY CCCEEEEECCCCCCH | 32.74 | - | |
| 731 | Ubiquitination | CRESYICKVNRKEDY CCCEEEEECCCCCCH | 32.74 | - | |
| 731 | Sumoylation | CRESYICKVNRKEDY CCCEEEEECCCCCCH | 32.74 | 28112733 | |
| 731 | Acetylation | CRESYICKVNRKEDY CCCEEEEECCCCCCH | 32.74 | 25953088 | |
| 735 | Ubiquitination | YICKVNRKEDYSRCL EEEECCCCCCHHHHH | 50.13 | - | |
| 748 | Ubiquitination | CLQIMLDKGKLWFRC HHHHHHCCCCEEEEE | 54.72 | - | |
| 748 | Sumoylation | CLQIMLDKGKLWFRC HHHHHHCCCCEEEEE | 54.72 | 28112733 | |
| 750 | Sumoylation | QIMLDKGKLWFRCSL HHHHCCCCEEEEEHH | 48.57 | - | |
| 750 | Sumoylation | QIMLDKGKLWFRCSL HHHHCCCCEEEEEHH | 48.57 | - | |
| 750 | Ubiquitination | QIMLDKGKLWFRCSL HHHHCCCCEEEEEHH | 48.57 | - | |
| 777 | Sumoylation | THIHQVHKEKSDEEE HHHHHHHHHCCCHHH | 68.90 | 28112733 | |
| 779 | Sumoylation | IHQVHKEKSDEEEQQ HHHHHHHCCCHHHHE | 68.93 | - | |
| 779 | Ubiquitination | IHQVHKEKSDEEEQQ HHHHHHHCCCHHHHE | 68.93 | 21906983 | |
| 779 | Sumoylation | IHQVHKEKSDEEEQQ HHHHHHHCCCHHHHE | 68.93 | 28112733 | |
| 779 (in isoform 2) | Ubiquitination | - | 68.93 | 21890473 | |
| 779 (in isoform 1) | Ubiquitination | - | 68.93 | 21890473 | |
| 790 | Sumoylation | EEQQYVIKCGTCTKA HHHEEEEEECCCCHH | 19.30 | - | |
| 790 | Ubiquitination | EEQQYVIKCGTCTKA HHHEEEEEECCCCHH | 19.30 | - | |
| 790 | Sumoylation | EEQQYVIKCGTCTKA HHHEEEEEECCCCHH | 19.30 | 28112733 | |
| 790 (in isoform 2) | Ubiquitination | - | 19.30 | - | |
| 796 | Ubiquitination | IKCGTCTKAFHDPES EEECCCCHHHCCHHH | 51.72 | - | |
| 811 | Sumoylation | AQQHFHRKHCFLQKP HHHHHHHHCCCCCCC | 35.83 | - | |
| 811 | Sumoylation | AQQHFHRKHCFLQKP HHHHHHHHCCCCCCC | 35.83 | - | |
| 811 | Ubiquitination | AQQHFHRKHCFLQKP HHHHHHHHCCCCCCC | 35.83 | - | |
| 817 | Sumoylation | RKHCFLQKPSVAHFG HHCCCCCCCCEEECC | 41.21 | - | |
| 817 | Sumoylation | RKHCFLQKPSVAHFG HHCCCCCCCCEEECC | 41.21 | 28112733 | |
| 817 | Ubiquitination | RKHCFLQKPSVAHFG HHCCCCCCCCEEECC | 41.21 | - | |
| 817 | Acetylation | RKHCFLQKPSVAHFG HHCCCCCCCCEEECC | 41.21 | 26051181 | |
| 819 | Phosphorylation | HCFLQKPSVAHFGSE CCCCCCCCEEECCCC | 38.68 | 30576142 | |
| 825 | Phosphorylation | PSVAHFGSEKSNLYK CCEEECCCCCCCEEE | 40.69 | 25159151 | |
| 827 | Sumoylation | VAHFGSEKSNLYKFT EEECCCCCCCEEEEE | 46.47 | - | |
| 827 | Ubiquitination | VAHFGSEKSNLYKFT EEECCCCCCCEEEEE | 46.47 | 21890473 | |
| 827 | Sumoylation | VAHFGSEKSNLYKFT EEECCCCCCCEEEEE | 46.47 | 28112733 | |
| 827 (in isoform 2) | Ubiquitination | - | 46.47 | 21890473 | |
| 827 (in isoform 1) | Ubiquitination | - | 46.47 | 21890473 | |
| 831 | Phosphorylation | GSEKSNLYKFTASAS CCCCCCEEEEECCCC | 14.33 | - | |
| 832 | Sumoylation | SEKSNLYKFTASASH CCCCCEEEEECCCCC | 39.13 | - | |
| 832 | Ubiquitination | SEKSNLYKFTASASH CCCCCEEEEECCCCC | 39.13 | 21890473 | |
| 832 | Sumoylation | SEKSNLYKFTASASH CCCCCEEEEECCCCC | 39.13 | 28112733 | |
| 832 (in isoform 2) | Ubiquitination | - | 39.13 | 21890473 | |
| 832 (in isoform 1) | Ubiquitination | - | 39.13 | 21890473 | |
| 834 | Phosphorylation | KSNLYKFTASASHTE CCCEEEEECCCCCHH | 18.62 | 30576142 | |
| 836 | Phosphorylation | NLYKFTASASHTERK CEEEEECCCCCHHHH | 27.52 | 29449344 | |
| 838 | Phosphorylation | YKFTASASHTERKLK EEEECCCCCHHHHHH | 28.57 | 29116813 | |
| 840 | Phosphorylation | FTASASHTERKLKQA EECCCCCHHHHHHHH | 34.68 | 30576142 | |
| 843 | Sumoylation | SASHTERKLKQAINY CCCCHHHHHHHHHHH | 54.53 | - | |
| 843 | Sumoylation | SASHTERKLKQAINY CCCCHHHHHHHHHHH | 54.53 | 28112733 | |
| 843 | Ubiquitination | SASHTERKLKQAINY CCCCHHHHHHHHHHH | 54.53 | - | |
| 845 | Sumoylation | SHTERKLKQAINYSK CCHHHHHHHHHHHHH | 40.49 | - | |
| 845 | Ubiquitination | SHTERKLKQAINYSK CCHHHHHHHHHHHHH | 40.49 | 21906983 | |
| 845 | Sumoylation | SHTERKLKQAINYSK CCHHHHHHHHHHHHH | 40.49 | 28112733 | |
| 845 (in isoform 2) | Ubiquitination | - | 40.49 | 21890473 | |
| 845 (in isoform 1) | Ubiquitination | - | 40.49 | 21890473 | |
| 850 | Phosphorylation | KLKQAINYSKSLDME HHHHHHHHHHCCCCC | 16.03 | 30576142 | |
| 852 | Sumoylation | KQAINYSKSLDMEKG HHHHHHHHCCCCCCC | 44.68 | - | |
| 852 | Ubiquitination | KQAINYSKSLDMEKG HHHHHHHHCCCCCCC | 44.68 | 21890473 | |
| 852 | Sumoylation | KQAINYSKSLDMEKG HHHHHHHHCCCCCCC | 44.68 | 28112733 | |
| 852 (in isoform 2) | Ubiquitination | - | 44.68 | 21890473 | |
| 852 (in isoform 1) | Ubiquitination | - | 44.68 | 21890473 | |
| 853 | Phosphorylation | QAINYSKSLDMEKGV HHHHHHHCCCCCCCC | 24.54 | 24719451 | |
| 858 | Ubiquitination | SKSLDMEKGVENDLS HHCCCCCCCCCCCCC | 62.71 | - | |
| 944 (in isoform 2) | Ubiquitination | - | 11.55 | 21890473 | |
| 951 | Ubiquitination | HPRCSKRKDAADFAI CCCCCCCCCHHHHHH | 56.29 | - | |
| 951 | Sumoylation | HPRCSKRKDAADFAI CCCCCCCCCHHHHHH | 56.29 | 28112733 | |
| 971 | Ubiquitination | RLDEQLPKQIPFTIL CCCCCCCCCCCEEEE | 70.25 | - | |
| 992 | Sumoylation | LELENQFKKTQRPAH HHHHHHHHHCCCCHH | 45.18 | - | |
| 992 | Ubiquitination | LELENQFKKTQRPAH HHHHHHHHHCCCCHH | 45.18 | 2190698 | |
| 992 | Sumoylation | LELENQFKKTQRPAH HHHHHHHHHCCCCHH | 45.18 | 28112733 | |
| 992 (in isoform 1) | Ubiquitination | - | 45.18 | 21890473 | |
| 993 | Ubiquitination | ELENQFKKTQRPAHI HHHHHHHHCCCCHHH | 51.70 | - | |
| 993 | Sumoylation | ELENQFKKTQRPAHI HHHHHHHHCCCCHHH | 51.70 | 28112733 | |
| 1023 | Ubiquitination | NSISDTTKECDSDDN HHHCCCCCCCCCCCC | 59.44 | - | |
| 1027 | Phosphorylation | DTTKECDSDDNMGAK CCCCCCCCCCCCCCC | 59.53 | 23401153 | |
| 1034 | Ubiquitination | SDDNMGAKNTSIGEE CCCCCCCCCCCCCCC | 55.84 | - | |
| 1036 | Phosphorylation | DNMGAKNTSIGEEFI CCCCCCCCCCCCCCC | 22.48 | 28348404 | |
| 1037 | Phosphorylation | NMGAKNTSIGEEFIS CCCCCCCCCCCCCCC | 37.68 | 29496963 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN451_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN451_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN451_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ANDR_HUMAN | AR | physical | 18656483 | |
| MPP5_HUMAN | MPP5 | physical | 23718855 | |
| KDM1A_HUMAN | KDM1A | physical | 23455924 | |
| JMJD6_HUMAN | JMJD6 | physical | 23455924 | |
| ANM1_HUMAN | PRMT1 | physical | 23455924 | |
| ANM8_HUMAN | PRMT8 | physical | 23455924 | |
| SUV91_HUMAN | SUV39H1 | physical | 23455924 | |
| ZN451_HUMAN | ZNF451 | physical | 18656483 | |
| UBC9_HUMAN | UBE2I | physical | 18656483 | |
| PIAS1_HUMAN | PIAS1 | physical | 18656483 | |
| PIAS2_HUMAN | PIAS2 | physical | 18656483 | |
| F118A_HUMAN | FAM118A | physical | 21516116 | |
| CDCA4_HUMAN | CDCA4 | physical | 21516116 | |
| UBC9_HUMAN | UBE2I | physical | 21516116 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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