CDCA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDCA4_HUMAN
• UniProt AC: Q9BXL8
• Protein Name: Cell division cycle-associated protein 4
• Gene Name: CDCA4
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Subcellular Localization: Nucleus .
• Protein Description: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity)..
• Protein Sequence: MFARGLKRKCVGHEEDVEGALAGLKTVSSYSLQRQSLLDMSLVKLQLCHMLVEPNLCRSVLIANTVRQIQEEMTQDGTWRTVAPQAAERAPLDRLVSTEILCRAAWGQEGAHPAPGLGDGHTQGPVSDLCPVTSAQAPRHLQSSAWEMDGPRENRGSFHKSLDQIFETLETKNPSCMEELFSDVDSPYYDLDTVLTGMMGGARPGPCEGLEGLAPATPGPSSSCKSDLGELDHVVEILVET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	FARGLKRKCVGHEED CCCCCCHHHCCCHHH	31.52	-
25	Ubiquitination	EGALAGLKTVSSYSL HHHHHHHHHHCCHHH	46.06	-
29	Phosphorylation	AGLKTVSSYSLQRQS HHHHHHCCHHHHHHH	17.88	23663014
30	Phosphorylation	GLKTVSSYSLQRQSL HHHHHCCHHHHHHHH	13.09	23663014
31	Phosphorylation	LKTVSSYSLQRQSLL HHHHCCHHHHHHHHH	21.70	23663014
74	Phosphorylation	RQIQEEMTQDGTWRT HHHHHHHHCCCCCEE	27.13	-
78	Phosphorylation	EEMTQDGTWRTVAPQ HHHHCCCCCEECCHH	21.77	-
97	Phosphorylation	APLDRLVSTEILCRA CCHHHHHCHHHHHHH	25.55	29978859
98	Phosphorylation	PLDRLVSTEILCRAA CHHHHHCHHHHHHHH	21.40	29978859
157	Phosphorylation	GPRENRGSFHKSLDQ CCCCCCCCHHHHHHH	22.42	-
160	Ubiquitination	ENRGSFHKSLDQIFE CCCCCHHHHHHHHHH	51.18	21906983
161	Phosphorylation	NRGSFHKSLDQIFET CCCCHHHHHHHHHHH	28.71	28348404
217	Phosphorylation	LEGLAPATPGPSSSC CCCCCCCCCCCCHHC	27.93	25850435
221	Phosphorylation	APATPGPSSSCKSDL CCCCCCCCHHCCCHH	40.58	25850435
222	Phosphorylation	PATPGPSSSCKSDLG CCCCCCCHHCCCHHH	42.78	25850435
223	Phosphorylation	ATPGPSSSCKSDLGE CCCCCCHHCCCHHHC	29.87	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDCA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDCA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDCA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2B_HUMAN	KAT2B	physical	17141982
ST65G_HUMAN	SUPT7L	physical	17141982
TIF1B_HUMAN	TRIM28	physical	17141982
XPO1_HUMAN	XPO1	physical	17141982
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
SUV92_HUMAN	SUV39H2	physical	23455924
XIAP_HUMAN	XIAP	physical	25691055
2ABD_HUMAN	PPP2R2D	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442
BDH2_HUMAN	BDH2	physical	28514442
NMNA1_HUMAN	NMNAT1	physical	28514442
CPNE7_HUMAN	CPNE7	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.