F118A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F118A_HUMAN
• UniProt AC: Q9NWS6
• Protein Name: Protein FAM118A
• Gene Name: FAM118A
• Organism: Homo sapiens (Human).
• Sequence Length: 357
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIPALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKPSFFQDCLMEVFDDLEQHIRSPVVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPMESLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYRTKSFLFVGCGETLRDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKVVSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKKRTQSDTDDAGGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSVEKTT -------CCCCHHHC	8.60	22814378
6	Ubiquitination	--MDSVEKTTNRSEQ --CCCCHHHCCHHHH	59.50	-
17	Ubiquitination	RSEQKSRKFLKSLIR HHHHHHHHHHHHHHH	63.24	-
20	Ubiquitination	QKSRKFLKSLIRKQP HHHHHHHHHHHHHCC	46.48	-
21	Phosphorylation	KSRKFLKSLIRKQPQ HHHHHHHHHHHHCCC	31.04	24719451
152	Ubiquitination	LTTNYDNLLEAFGRR EEECHHHHHHHHHHH	4.11	-
170	Trimethylation	PMESLDLKDKTKVLE CCCCCCCCCHHHHHH	57.77	-
170	Methylation	PMESLDLKDKTKVLE CCCCCCCCCHHHHHH	57.77	-
174	Acetylation	LDLKDKTKVLEWARG CCCCCHHHHHHHHHH	51.03	20167786
224	Phosphorylation	MEVLQNLYRTKSFLF HHHHHHHHCCCCEEE	24.64	22210691
226	Phosphorylation	VLQNLYRTKSFLFVG HHHHHHCCCCEEEEC	19.92	22210691
273	Ubiquitination	ENEDHFFKHQADMLL CCCCHHHHHHHHHHH	33.59	-
311	Phosphorylation	TQICKQQSPDADRVD HHHHHHCCCCCCCCC	23.42	23927012
319	Phosphorylation	PDADRVDSTTLLGNA CCCCCCCHHHHHHHH	22.04	23927012
320	Phosphorylation	DADRVDSTTLLGNAC CCCCCCHHHHHHHHH	19.59	23927012
321	Phosphorylation	ADRVDSTTLLGNACQ CCCCCHHHHHHHHHH	24.76	23927012
334	Ubiquitination	CQDCAKRKLEENGIE HHHHHHHHHHHCCCE	60.59	-
343	Phosphorylation	EENGIEVSKKRTQSD HHCCCEECCCCCCCC	21.48	-
347	Phosphorylation	IEVSKKRTQSDTDDA CEECCCCCCCCCCCC	41.11	28102081
349	Phosphorylation	VSKKRTQSDTDDAGG ECCCCCCCCCCCCCC	41.69	30576142
351	Phosphorylation	KKRTQSDTDDAGGS- CCCCCCCCCCCCCC-	40.81	28102081
357	Phosphorylation	DTDDAGGS------- CCCCCCCC-------	35.81	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F118A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F118A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F118A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F118A_HUMAN	FAM118A	physical	25416956
MOB1A_HUMAN	MOB1A	physical	25416956
AIDA_HUMAN	AIDA	physical	25416956
F118B_HUMAN	FAM118B	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
MOB3C_HUMAN	MOB3C	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.