AIDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AIDA_HUMAN
• UniProt AC: Q96BJ3
• Protein Name: Axin interactor, dorsalization-associated protein
• Gene Name: AIDA
• Organism: Homo sapiens (Human).
• Sequence Length: 306
• Protein Description: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity)..
• Protein Sequence: MSEVTRSLLQRWGASFRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNILTYNKEFPFDVQPVPLRRILAPGEEENLEFEEDEEEGGAGAGSPDSFPARVPGTLLPRLPSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LLQRWGASFRRGADF HHHHHCCCCCCCCCC	18.49	27251275
24	Phosphorylation	RRGADFDSWGQLVEA CCCCCCCCHHHHHHH	32.85	113330853
62	Phosphorylation	FTEEQKKTIGKIATC CCHHHHHHHHHHHHH	41.83	23403867
68	Phosphorylation	KTIGKIATCLELRSA HHHHHHHHHHHHHHH	22.54	23403867
79	Phosphorylation	LRSAALQSTQSQEEF HHHHHHHCCCCCCCC	29.30	27251275
80	Phosphorylation	RSAALQSTQSQEEFK HHHHHHCCCCCCCCC	21.19	27251275
82	Phosphorylation	AALQSTQSQEEFKLE HHHHCCCCCCCCCHH	39.38	26471730
144	Phosphorylation	EGGAGAGSPDSFPAR CCCCCCCCCCCCCCC	25.62	25159151
147	Phosphorylation	AGAGSPDSFPARVPG CCCCCCCCCCCCCCC	36.19	22199227
155	Phosphorylation	FPARVPGTLLPRLPS CCCCCCCCCCCCCCC	21.03	37604329
162	Phosphorylation	TLLPRLPSEPGMTLL CCCCCCCCCCCCEEE	62.10	27499020
167	Phosphorylation	LPSEPGMTLLTIRIE CCCCCCCEEEEEEEE	25.24	31437747
170	Phosphorylation	EPGMTLLTIRIEKIG CCCCEEEEEEEEECC	16.01	68716917
188	Phosphorylation	AGQCIDPYITVSVKD CCCCCCCEEEEEEEC	12.89	46160909
232	"N6,N6-dimethyllysine"	ELQKHVEKLTKGAAI HHHHHHHHHHHCCEE	61.44	-
232	Methylation	ELQKHVEKLTKGAAI HHHHHHHHHHHCCEE	61.44	-
235	Acetylation	KHVEKLTKGAAIFFE HHHHHHHHCCEEEEE	57.92	20167786
276	Phosphorylation	GPIVIELYKKPTDFK CCEEEEEECCCCCCC	12.27	21406692
296	Phosphorylation	LLTKKPLYLHLHQTL HHHCCCCCHHHHHHC	10.70	68730133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AIDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AIDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AIDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
AIDA_HUMAN	AIDA	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND MASSSPECTROMETRY.
PubMed: 18669648