DBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DBP_HUMAN
• UniProt AC: Q10586
• Protein Name: D site-binding protein
• Gene Name: DBP
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Subcellular Localization: Nucleus.
• Protein Description: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation..
• Protein Sequence: MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSKPKEPASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAALGTASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LLGGPAGTPPGGGAL ECCCCCCCCCCCHHH	28.54	28857561
63	Phosphorylation	AALPAATTPGPGLET HHCCCCCCCCCCCCC	22.86	21712546
70	Phosphorylation	TPGPGLETAGPADAP CCCCCCCCCCCCCCC	41.79	28555341
86	Phosphorylation	GAVVGGGSPRGRPGP CCEECCCCCCCCCCC	18.07	30175587
143	Phosphorylation	GGPSPEPSPARTPAP CCCCCCCCCCCCCCC	29.54	-
151	Phosphorylation	PARTPAPSPGPGSCG CCCCCCCCCCCCCCC	44.59	28985074
156	Phosphorylation	APSPGPGSCGSASPR CCCCCCCCCCCCCCC	20.59	30108239
159	Phosphorylation	PGPGSCGSASPRSSP CCCCCCCCCCCCCCC	29.87	25849741
161	Phosphorylation	PGSCGSASPRSSPGH CCCCCCCCCCCCCCC	23.65	25849741
164	Phosphorylation	CGSASPRSSPGHAPA CCCCCCCCCCCCHHH	44.24	27794612
165	Phosphorylation	GSASPRSSPGHAPAR CCCCCCCCCCCHHHH	35.86	25849741
177	Phosphorylation	PARAALGTASGHRAG HHHHHHCCCCCCCCC	20.64	22210691
179	Phosphorylation	RAALGTASGHRAGLT HHHHCCCCCCCCCCC	34.66	22210691
186	Phosphorylation	SGHRAGLTSRDTPSP CCCCCCCCCCCCCCC	22.31	28985074
231	Phosphorylation	DPRRHRFSEEELKPQ CCCCCCCCHHHHCCC	44.02	21815630
257	Sumoylation	PEEQKDEKYWSRRYK CHHHCCHHHHHHHHH	63.25	-
257	Ubiquitination	PEEQKDEKYWSRRYK CHHHCCHHHHHHHHH	63.25	29967540
257	Sumoylation	PEEQKDEKYWSRRYK CHHHCCHHHHHHHHH	63.25	-
264	Acetylation	KYWSRRYKNNEAAKR HHHHHHHHCCHHHHH	52.03	7910649
284	Phosphorylation	RLKENQISVRAAFLE HHHHHHHHHHHHHHH	8.86	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BATF3_HUMAN	BATF3	physical	23661758
BATF2_HUMAN	BATF2	physical	23661758
BATF_HUMAN	BATF	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
EPAS1_HUMAN	EPAS1	physical	23661758
CEBPA_HUMAN	CEBPA	physical	23661758
CEBPG_HUMAN	CEBPG	physical	23661758
DDIT3_HUMAN	DDIT3	physical	23661758
DDIT3_HUMAN	DDIT3	physical	21988832
HLF_HUMAN	HLF	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.