dbPTM

BACH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BACH2_HUMAN
UniProt AC	Q9BYV9
Protein Name	Transcription regulator protein BACH2
Gene Name	BACH2
Organism	Homo sapiens (Human).
Sequence Length	841
Subcellular Localization	Cytoplasm . Nucleus . Nucleocytoplasmic shuttling is controlled by phosphorylation.
Protein Description	Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. [PubMed: 17018862 Positively regulates the nuclear import of actin (By similarity]
Protein Sequence	MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVDEKPDS ------CCCCCCCCC	37.97	25072903
9	Phosphorylation	SVDEKPDSPMYVYES CCCCCCCCCCEEEEE	21.79	25072903
12	Phosphorylation	EKPDSPMYVYESTVH CCCCCCCEEEEEECC	11.85	25072903
14	Phosphorylation	PDSPMYVYESTVHCT CCCCCEEEEEECCHH	6.15	25072903
16	Phosphorylation	SPMYVYESTVHCTNI CCCEEEEEECCHHHH	20.31	25072903
17	Phosphorylation	PMYVYESTVHCTNIL CCEEEEEECCHHHHH	11.43	25072903
21	Phosphorylation	YESTVHCTNILLGLN EEEECCHHHHHHCCC	15.49	25072903
159	Phosphorylation	PHEDCENSAGEEEDE CCHHHCCCCCCCCHH	18.50	23401153
170	Phosphorylation	EEDEEEETMDSETAK CCHHHHHHCCHHHHH	29.56	30576142
175	Phosphorylation	EETMDSETAKMACPR HHHCCHHHHHHHCCH	35.21	30576142
177	Phosphoglycerylation	TMDSETAKMACPRDQ HCCHHHHHHHCCHHH	34.16	-
202	Sumoylation	AAIPVAEKEEALLPE EECCHHHHHHHHCCC	51.63	-
202	Sumoylation	AAIPVAEKEEALLPE EECCHHHHHHHHCCC	51.63	-
231	Phosphorylation	ALTQYPRYKKYQLAC HHHHCHHHHHHHEEE	13.82	26657352
234	Phosphorylation	QYPRYKKYQLACTKN HCHHHHHHHEEEECC	12.47	26657352
267	Ubiquitination	DNSSNSLKPGLARGQ CCCCCCCCCCHHHCC	36.54	29967540
276	Sumoylation	GLARGQIKSEPPSEE CHHHCCCCCCCCCCC	40.66	-
276	Sumoylation	GLARGQIKSEPPSEE CHHHCCCCCCCCCCC	40.66	-
294	Phosphorylation	ESITLCLSGDEPDAK CCEEEEECCCCCCHH	43.11	30576142
315	Phosphorylation	EMDRKQPSPAPTPTA CCCCCCCCCCCCCCC	31.06	23401153
319	Phosphorylation	KQPSPAPTPTAPAGA CCCCCCCCCCCCCHH	35.06	30266825
321	Phosphorylation	PSPAPTPTAPAGAAC CCCCCCCCCCCHHHH	47.99	30266825
332	Phosphorylation	GAACLERSRSVASPS HHHHHHHHCCCCCHH	21.38	27251275
334	Phosphorylation	ACLERSRSVASPSCL HHHHHHCCCCCHHHH	24.23	30576142
337	Phosphorylation	ERSRSVASPSCLRSL HHHCCCCCHHHHHHH	18.39	23401153
339	Phosphorylation	SRSVASPSCLRSLFS HCCCCCHHHHHHHHH	24.24	26552605
343	Phosphorylation	ASPSCLRSLFSITKS CCHHHHHHHHHHCCC	22.33	24719451
350	Phosphorylation	SLFSITKSVELSGLP HHHHHCCCEEECCCC	16.51	24667141
382	Sumoylation	GITQGDLKTDYTPFT CCCCCCCCCCCCCCC	44.05	28112733
382	Ubiquitination	GITQGDLKTDYTPFT CCCCCCCCCCCCCCC	44.05	29967540
383	O-linked_Glycosylation	ITQGDLKTDYTPFTG CCCCCCCCCCCCCCC	41.35	29351928
386	O-linked_Glycosylation	GDLKTDYTPFTGNYG CCCCCCCCCCCCCCC	18.09	29351928
389	O-linked_Glycosylation	KTDYTPFTGNYGQPH CCCCCCCCCCCCCCC	26.22	29351928
400	Ubiquitination	GQPHVGQKEVSNFTM CCCCCCCEEEECCCC	54.90	29967540
403	Phosphorylation	HVGQKEVSNFTMGSP CCCCEEEECCCCCCC	27.58	30266825
406	Phosphorylation	QKEVSNFTMGSPLRG CEEEECCCCCCCCCC	25.52	30266825
409	Phosphorylation	VSNFTMGSPLRGPGL EECCCCCCCCCCCCH	15.22	23401153
421	Sumoylation	PGLEALCKQEGELDR CCHHHHHHCCCCCCC	52.84	-
421	Sumoylation	PGLEALCKQEGELDR CCHHHHHHCCCCCCC	52.84	28112733
443	O-linked_Glycosylation	SACDQVSTSVHSYSG HHHCCCCCCCCCCCC	35.59	29351928
444	O-linked_Glycosylation	ACDQVSTSVHSYSGV HHCCCCCCCCCCCCC	15.44	29351928
459	O-linked_Glycosylation	SSLDKDLSEPVPKGL CCCCCCCCCCCCCCC	50.41	29351928
473	Phosphorylation	LWVGAGQSLPSSQAY CEECCCCCCCCCCCC	41.13	26714015
476	Phosphorylation	GAGQSLPSSQAYSHG CCCCCCCCCCCCCCC	40.13	26714015
476	O-linked_Glycosylation	GAGQSLPSSQAYSHG CCCCCCCCCCCCCCC	40.13	29351928
477	Phosphorylation	AGQSLPSSQAYSHGG CCCCCCCCCCCCCCC	19.52	22210691
480	Phosphorylation	SLPSSQAYSHGGLMA CCCCCCCCCCCCCCC	8.12	26714015
481	Phosphorylation	LPSSQAYSHGGLMAD CCCCCCCCCCCCCCC	20.76	22210691
499	O-linked_Glycosylation	GRMRPNTSCPVPIKV CCCCCCCCCCCCEEE	24.06	29351928
505	Acetylation	TSCPVPIKVCPRSPP CCCCCCEEECCCCCC	31.54	25953088
510	Phosphorylation	PIKVCPRSPPLETRT CEEECCCCCCCCCEE	18.93	23401153
515	Phosphorylation	PRSPPLETRTRTSSS CCCCCCCCEEECCCC	45.05	29978859
521	Phosphorylation	ETRTRTSSSCSSYSY CCEEECCCCCCCCEE	34.45	28112733
524	Phosphorylation	TRTSSSCSSYSYAED EECCCCCCCCEECCC	33.97	30576142
525	Phosphorylation	RTSSSCSSYSYAEDG ECCCCCCCCEECCCC	23.56	-
527	Phosphorylation	SSSCSSYSYAEDGSG CCCCCCCEECCCCCC	21.58	-
536	Phosphorylation	AEDGSGGSPCSLPLC CCCCCCCCCCCCEEC	26.68	30576142
546	Phosphorylation	SLPLCEFSSSPCSQG CCEECCCCCCCCHHH	13.96	26074081
547	Phosphorylation	LPLCEFSSSPCSQGA CEECCCCCCCCHHHH	43.55	26074081
548	Phosphorylation	PLCEFSSSPCSQGAR EECCCCCCCCHHHHH	28.82	26074081
551	Phosphorylation	EFSSSPCSQGARFLA CCCCCCCHHHHHHHE	34.72	26074081
572	Phosphorylation	GLMGDGMYNQVRPQI CCCCCCCCCCCCCCC	14.15	27642862
580	Sumoylation	NQVRPQIKCEQSYGT CCCCCCCEEEECCCC	26.86	-
580	Sumoylation	NQVRPQIKCEQSYGT CCCCCCCEEEECCCC	26.86	-
719	Phosphorylation	EVCRDIQSPEQIQAL HHHHHCCCHHHHHHH	30.64	32142685
817	Phosphorylation	PLEPRSQTVTVDFCQ CCCCCCCEEEEECHH	21.28	30622161
819	Phosphorylation	EPRSQTVTVDFCQEM CCCCCEEEEECHHHH	20.11	30622161
827	Phosphorylation	VDFCQEMTDKCTTDE EECHHHHHHCCCCCC	31.39	30622161
831	Phosphorylation	QEMTDKCTTDEQPRK HHHHHCCCCCCCCCC	42.92	30257219
832	O-linked_Glycosylation	EMTDKCTTDEQPRKD HHHHCCCCCCCCCCC	47.19	29351928
832	Phosphorylation	EMTDKCTTDEQPRKD HHHHCCCCCCCCCCC	47.19	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
521	S	Phosphorylation	Kinase	P70S6K	P23443	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
521	S	Phosphorylation		17018862
Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BACH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PATZ1_HUMAN	PATZ1	physical	10669750
BCL6_HUMAN	BCL6	physical	18256039
MAFG_HUMAN	MAFG	physical	23661758
MAFF_HUMAN	MAFF	physical	23661758

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BACH2_HUMAN

Related Literatures of Post-Translational Modification

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