PATZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PATZ1_HUMAN
• UniProt AC: Q9HBE1
• Protein Name: POZ-, AT hook-, and zinc finger-containing protein 1
• Gene Name: PATZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 687
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor..
• Protein Sequence: MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSRTRKQVACEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQSCGKGFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPMGPEGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MERVNDASCGPSGCY CCCCCCCCCCCCCCE	23.59	27251275
17	Phosphorylation	GPSGCYTYQVSRHST CCCCCEEHHEECCCH	4.77	-
20	Phosphorylation	GCYTYQVSRHSTEML CCEEHHEECCCHHHH	14.57	-
112	Sumoylation	EMHTISSKVFGDILD EEEECCCHHHHHHHH	34.49	28112733
132	Phosphorylation	RIVVRLESFPELMTA CEEEEHHHHHHHHHH	51.17	29978859
138	Phosphorylation	ESFPELMTAAKFLLM HHHHHHHHHHHHHHH	35.77	29978859
157	Ubiquitination	EICQEVIKQSNVQIL HHHHHHHHHCCCEEE	53.50	-
225	Phosphorylation	AAIAGQASLPVLPGV HHHCCCCCCCCCCCC	25.89	20068231
243	Phosphorylation	PMVAGPLSPQLLTSP CCCCCCCCHHHHCCC	17.46	29255136
248	Phosphorylation	PLSPQLLTSPFPSVA CCCHHHHCCCCCHHH	42.84	29255136
249	Phosphorylation	LSPQLLTSPFPSVAS CCHHHHCCCCCHHHC	25.23	29255136
253	Phosphorylation	LLTSPFPSVASSAPP HHCCCCCHHHCCCCC	30.60	29255136
256	Phosphorylation	SPFPSVASSAPPLTG CCCCHHHCCCCCCCC	25.52	27251275
257	Phosphorylation	PFPSVASSAPPLTGK CCCHHHCCCCCCCCC	34.75	29255136
262	Phosphorylation	ASSAPPLTGKRGRGR HCCCCCCCCCCCCCC	46.56	20068231
272	Sumoylation	RGRGRPRKANLLDSM CCCCCCCHHHHHHHH	44.29	28112733
272	Ubiquitination	RGRGRPRKANLLDSM CCCCCCCHHHHHHHH	44.29	-
278	Phosphorylation	RKANLLDSMFGSPGG CHHHHHHHHHCCCCC	18.91	29255136
282	Phosphorylation	LLDSMFGSPGGLREA HHHHHHCCCCCHHHC	14.76	29255136
299	Ubiquitination	LPCGLCGKVFTDANR ECCCCCCCEECCHHH	32.93	-
353	Ubiquitination	RKRSRTRKQVACEIC CCCCCCHHHHHHHHH	48.81	-
376	Phosphorylation	HLNRHKLSHSGEKPY HHHCCCCCCCCCCCC	22.02	27732954
378	Phosphorylation	NRHKLSHSGEKPYSC HCCCCCCCCCCCCCC	45.32	20068231
383	Phosphorylation	SHSGEKPYSCPVCGL CCCCCCCCCCCCCCE	33.69	27732954
384	Phosphorylation	HSGEKPYSCPVCGLR CCCCCCCCCCCCCEE	22.07	27732954
397	Methylation	LRFKRKDRMSYHVRS EEEEECCCEEEEEEC	20.98	-
399	Phosphorylation	FKRKDRMSYHVRSHD EEECCCEEEEEECCC	17.00	27251275
400	Phosphorylation	KRKDRMSYHVRSHDG EECCCEEEEEECCCC	8.59	27251275
411	Acetylation	SHDGSVGKPYICQSC CCCCCCCCCEEECCC	32.27	26051181
417	Phosphorylation	GKPYICQSCGKGFSR CCCEEECCCCCCCCC	22.04	25159151
459	Phosphorylation	ATRDRLRSHLACHED HHHHHHHHHHCCCCC	27.69	28555341
475	Acetylation	VPCQVCGKYLRAAYM CCHHHHHHHHHHHHH	35.66	26051181
490	Phosphorylation	ADHLKKHSEGPSNFC HHHHHHHCCCCCCCH	53.80	28555341
490 (in isoform 3)	Phosphorylation	-	53.80	25159151
493 (in isoform 4)	Phosphorylation	-	23.27	-
494 (in isoform 3)	Phosphorylation	-	54.09	25159151
523 (in isoform 4)	Phosphorylation	-	26.85	27251275
524 (in isoform 4)	Phosphorylation	-	54.20	27251275
536 (in isoform 2)	Phosphorylation	-	16.80	28450419
554	Phosphorylation	NKEGQKCSHQDPIES CCCCCCCCCCCCCCC	31.08	27732954
561	Phosphorylation	SHQDPIESSDSYGDL CCCCCCCCCCCCCCC	39.92	27732954
562	Phosphorylation	HQDPIESSDSYGDLS CCCCCCCCCCCCCCC	20.13	27732954
564	Phosphorylation	DPIESSDSYGDLSDA CCCCCCCCCCCCCCH	32.72	27732954
565	Phosphorylation	PIESSDSYGDLSDAS CCCCCCCCCCCCCHH	21.46	27732954
569	Phosphorylation	SDSYGDLSDASDLKT CCCCCCCCCHHHCCC	35.55	27732954
572	Phosphorylation	YGDLSDASDLKTPEK CCCCCCHHHCCCCCC	48.76	27732954
576	Phosphorylation	SDASDLKTPEKQSAN CCHHHCCCCCCCCCC	43.93	25849741
585	Phosphorylation	EKQSANGSFSCDMAV CCCCCCCCCCCCEEC	17.50	25159151
587	Phosphorylation	QSANGSFSCDMAVPK CCCCCCCCCCEECCC	15.76	27251275
596	Ubiquitination	DMAVPKNKMESDGEK CEECCCCCCCCCCCC	50.61	-
612	Phosphorylation	YPCPECGSFFRSKSY CCCCCCCHHHHCHHH	32.63	24719451
616	Phosphorylation	ECGSFFRSKSYLNKH CCCHHHHCHHHHHHH	22.31	-
622	Ubiquitination	RSKSYLNKHIQKVHV HCHHHHHHHHHHHHH	39.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PATZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PATZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PATZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF4_HUMAN	RNF4	physical	10713105
ANDR_HUMAN	AR	physical	11719514
RNF4_HUMAN	RNF4	physical	11719514
MITF_HUMAN	MITF	physical	11751862
BCL6_HUMAN	BCL6	physical	22493480
P53_HUMAN	TP53	physical	25755280
PATZ1_HUMAN	PATZ1	physical	25755280
AIPL1_HUMAN	AIPL1	physical	27173435
PDE5A_HUMAN	PDE5A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.