PDE5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE5A_HUMAN
• UniProt AC: O76074
• Protein Name: cGMP-specific 3',5'-cyclic phosphodiesterase
• Gene Name: PDE5A
• Organism: Homo sapiens (Human).
• Sequence Length: 875
• Protein Description: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. [PubMed: 9714779]
• Protein Sequence: MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	KEGIRGHTESCSCPL CCCCCCCCCCCCCCC	32.20	28060719
78	Phosphorylation	GIRGHTESCSCPLQQ CCCCCCCCCCCCCCC	16.70	28060719
80	Phosphorylation	RGHTESCSCPLQQSP CCCCCCCCCCCCCCC	28.22	28060719
86	Phosphorylation	CSCPLQQSPRADNSA CCCCCCCCCCCCCCC	11.91	30266825
92	Phosphorylation	QSPRADNSAPGTPTR CCCCCCCCCCCCCCC	36.07	28188228
96	Phosphorylation	ADNSAPGTPTRKISA CCCCCCCCCCCCCCH	22.04	28060719
98	Phosphorylation	NSAPGTPTRKISASE CCCCCCCCCCCCHHH	44.42	28060719
102	Phosphorylation	GTPTRKISASEFDRP CCCCCCCCHHHCCCC	28.86	28348404
104	Phosphorylation	PTRKISASEFDRPLR CCCCCCHHHCCCCCC	31.82	26657352
137	Phosphorylation	KKEQMPLTPPRFDHD HHHCCCCCCCCCCCC	25.94	26657352
243	Ubiquitination	LGEPLNIKDAYEDPR HCCCCCHHHHHCCCC	34.92	-
601	Phosphorylation	VLCRWILSVKKNYRK HHHHHHHHHHHHHHH	23.82	24719451
633	Ubiquitination	FAALKAGKIQNKLTD HHHHHCCCCCCCCCH	46.08	-
672 (in isoform 2)	Ubiquitination	-	5.24	21890473
714	Ubiquitination	EEYKTTLKIIKQAIL HHHHHHHHHHHHHHH	40.05	21890473
714 (in isoform 1)	Ubiquitination	-	40.05	21890473
802	Phosphorylation	KELNIEPTDLMNREK HHCCCCHHHHCCHHH	29.04	29083192
869	Phosphorylation	KMLINGESGQAKRN- HHHHCCCCCCCCCC-	37.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
102	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
102	S	Phosphorylation	Kinase	PKACA	P17612	PSP
102	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
102	S	Phosphorylation	Kinase	KGP1	Q13976	PhosphoELM
102	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
102	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
102	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
102	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	RHOBTB1	O94844	PMID:30896450

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIPL1_HUMAN	AIPL1	physical	27173435
WDR24_HUMAN	WDR24	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB06237: Avanafil
• DB00201: Caffeine
• DB00975: Dipyridamole
• DB00806: Pentoxifylline
• DB00203: Sildenafil
• DB00820: Tadalafil
• DB00277: Theophylline
• DB06267: Udenafil
• DB00862: Vardenafil