RMD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMD1_HUMAN
• UniProt AC: Q96DB5
• Protein Name: Regulator of microtubule dynamics protein 1
• Gene Name: RMDN1
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
• Protein Sequence: MALAARLWRLLPFRRGAAPGSRLPAGTSGSRGHCGPCRFRGFEVMGNPGTFKRGLLLSALSYLGFETYQVISQAAVVHATAKVEEILEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVYEALEYAKRALEKNESSFASHKWYAICLSDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTFAEMPWYQRRIAKMLFATPPSSTYEKALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLMKAKDYPAHTEEDKQIQTEAAQLLTSFSEKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RRGAAPGSRLPAGTS CCCCCCCCCCCCCCC	29.59	23911959
28	Phosphorylation	SRLPAGTSGSRGHCG CCCCCCCCCCCCCCC	33.58	23911959
30	O-linked_Glycosylation	LPAGTSGSRGHCGPC CCCCCCCCCCCCCCC	34.55	30379171
92	Phosphorylation	EILEQADYLYESGET HHHHHCCHHHHCCCH	17.75	-
134	Phosphorylation	DVAQLSRTSEEEKKL HHHHHCCCCHHHHHH	36.79	24260401
156	Ubiquitination	YAKRALEKNESSFAS HHHHHHHHCCHHCCC	67.85	-
165	Succinylation	ESSFASHKWYAICLS CHHCCCCCEEEEEHH	39.13	-
165	Succinylation	ESSFASHKWYAICLS CHHCCCCCEEEEEHH	39.13	-
167	Phosphorylation	SFASHKWYAICLSDV HCCCCCEEEEEHHHC	7.29	-
177	Phosphorylation	CLSDVGDYEGIKAKI EHHHCCCHHHHHHHH	15.32	-
181	Ubiquitination	VGDYEGIKAKIANAY CCCHHHHHHHHHHHH	55.26	-
188	Phosphorylation	KAKIANAYIIKEHFE HHHHHHHHHHHHHHH	11.73	28152594
191	Acetylation	IANAYIIKEHFEKAI HHHHHHHHHHHHHHH	35.26	23236377
196	Ubiquitination	IIKEHFEKAIELNPK HHHHHHHHHHHCCHH	54.44	-
200	Ubiquitination	HFEKAIELNPKDATS HHHHHHHCCHHCCCE	12.43	21890473
200	Ubiquitination	HFEKAIELNPKDATS HHHHHHHCCHHCCCE	12.43	21890473
213	Ubiquitination	TSIHLMGIWCYTFAE CEEEEEEEHHHHHHH	1.11	21890473
213	Ubiquitination	TSIHLMGIWCYTFAE CEEEEEEEHHHHHHH	1.11	21890473
230	Ubiquitination	WYQRRIAKMLFATPP HHHHHHHHHHHCCCC	33.49	21890473
231	Ubiquitination	YQRRIAKMLFATPPS HHHHHHHHHHCCCCC	2.48	21890473
231	Ubiquitination	YQRRIAKMLFATPPS HHHHHHHHHHCCCCC	2.48	21890473
239	Phosphorylation	LFATPPSSTYEKALG HHCCCCCCHHHHHHH	40.56	24114839
240	Phosphorylation	FATPPSSTYEKALGY HCCCCCCHHHHHHHH	39.78	22210691
241	Phosphorylation	ATPPSSTYEKALGYF CCCCCCHHHHHHHHH	19.85	22210691
243	Ubiquitination	PPSSTYEKALGYFHR CCCCHHHHHHHHHHH	38.20	21890473
247	Phosphorylation	TYEKALGYFHRAEQV HHHHHHHHHHHHHHC	9.32	-
261	Ubiquitination	VDPNFYSKNLLLLGK CCCCHHCHHHHHHCH	39.99	21890473
268	Ubiquitination	KNLLLLGKTYLKLHN HHHHHHCHHHHHHCC	33.69	-
269	Phosphorylation	NLLLLGKTYLKLHNK HHHHHCHHHHHHCCH	32.08	20058876
270	Phosphorylation	LLLLGKTYLKLHNKK HHHHCHHHHHHCCHH	12.82	20049867
272	Ubiquitination	LLGKTYLKLHNKKLA HHCHHHHHHCCHHHH	36.97	-
297	Ubiquitination	PAHTEEDKQIQTEAA CCCCHHHHHHHHHHH	53.21	-
311	Phosphorylation	AQLLTSFSEKN---- HHHHHHHHCCC----	47.64	-
313	Ubiquitination	LLTSFSEKN------ HHHHHHCCC------	67.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHC1_HUMAN	SHC1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.