HSP7E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP7E_HUMAN
• UniProt AC: Q0VDF9
• Protein Name: Heat shock 70 kDa protein 14
• Gene Name: HSPA14
• Organism: Homo sapiens (Human).
• Sequence Length: 509
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity..
• Protein Sequence: MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEIAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	NDAGDRVTPAVVAYS CCCCCCCCCEEEEEE	13.36	21406692
41	Phosphorylation	VTPAVVAYSENEEIV CCCEEEEEECCCCHH	12.61	21406692
42	Phosphorylation	TPAVVAYSENEEIVG CCEEEEEECCCCHHH	24.98	21406692
53	Ubiquitination	EIVGLAAKQSRIRNI CHHHHHHCHHHHHHH	43.10	-
66	Ubiquitination	NISNTVMKVKQILGR HHHHHHHHHHHHHCC	41.78	-
68	Ubiquitination	SNTVMKVKQILGRSS HHHHHHHHHHHCCCC	26.55	-
74	Phosphorylation	VKQILGRSSSDPQAQ HHHHHCCCCCCHHHH	32.18	29978859
75	Phosphorylation	KQILGRSSSDPQAQK HHHHCCCCCCHHHHH	37.08	20068231
76	Phosphorylation	QILGRSSSDPQAQKY HHHCCCCCCHHHHHH	55.33	20068231
82	Acetylation	SSDPQAQKYIAESKC CCCHHHHHHHHCCCE	41.46	26051181
82	Ubiquitination	SSDPQAQKYIAESKC CCCHHHHHHHHCCCE	41.46	-
83	Phosphorylation	SDPQAQKYIAESKCL CCHHHHHHHHCCCEE	8.03	20068231
87	Phosphorylation	AQKYIAESKCLVIEK HHHHHHCCCEEEEEE	21.46	30576142
88	Ubiquitination	QKYIAESKCLVIEKN HHHHHCCCEEEEEEC	24.08	-
94	Ubiquitination	SKCLVIEKNGKLRYE CCEEEEEECCEEEEE	60.93	-
94	Acetylation	SKCLVIEKNGKLRYE CCEEEEEECCEEEEE	60.93	25953088
100	Phosphorylation	EKNGKLRYEIDTGEE EECCEEEEEEECCCC	27.89	-
109	Ubiquitination	IDTGEETKFVNPEDV EECCCCCCCCCHHHH	51.07	-
122	Phosphorylation	DVARLIFSKMKETAH HHHHHHHHHHHHHHH	25.50	24719451
123	Ubiquitination	VARLIFSKMKETAHS HHHHHHHHHHHHHHH	43.15	-
125	Ubiquitination	RLIFSKMKETAHSVL HHHHHHHHHHHHHHH	56.50	-
127	Phosphorylation	IFSKMKETAHSVLGS HHHHHHHHHHHHHCC	24.93	23917254
150	Ubiquitination	VPFDFGEKQKNALGE EECCCCHHHHHHHHH	67.94	-
152	Ubiquitination	FDFGEKQKNALGEAA CCCCHHHHHHHHHHH	56.08	-
180	Phosphorylation	PSAALLAYGIGQDSP HHHHHHHHCCCCCCC	14.83	26074081
186	Phosphorylation	AYGIGQDSPTGKSNI HHCCCCCCCCCCCCE	19.24	22617229
188	Phosphorylation	GIGQDSPTGKSNILV CCCCCCCCCCCCEEE	62.28	30108239
191	Phosphorylation	QDSPTGKSNILVFKL CCCCCCCCCEEEEEE	30.37	26074081
219	Phosphorylation	SGIYRVLSTNTDDNI CCCEEECCCCCCCCC	19.43	-
260	Acetylation	GNARAMMKLTNSAEV HCHHHHHHHCCHHHH	38.79	25953088
273	Phosphorylation	EVAKHSLSTLGSANC HHHHHHHHHHHHCCC	25.30	30576142
286	Phosphorylation	NCFLDSLYEGQDFDC CCHHHHHHCCCCCCC	23.20	30576142
296	Phosphorylation	QDFDCNVSRARFELL CCCCCCCCHHHHHHH	13.26	30576142
305	Phosphorylation	ARFELLCSPLFNKCI HHHHHHHHHHHHHHH	25.30	21406692
310	Ubiquitination	LCSPLFNKCIEAIRG HHHHHHHHHHHHHHH	29.29	-
310	Acetylation	LCSPLFNKCIEAIRG HHHHHHHHHHHHHHH	29.29	26051181
331	Ubiquitination	FTADDINKVVLCGGS CCHHHCCEEEECCCC	33.77	-
331	Acetylation	FTADDINKVVLCGGS CCHHHCCEEEECCCC	33.77	26051181
343	Acetylation	GGSSRIPKLQQLIKD CCCCHHHHHHHHHHH	57.46	25953088
343	Ubiquitination	GGSSRIPKLQQLIKD CCCCHHHHHHHHHHH	57.46	-
402	Ubiquitination	SARDILVKGVDESGA CHHHEEEEECCCCCC	50.17	-
402	Acetylation	SARDILVKGVDESGA CHHHEEEEECCCCCC	50.17	26051181
413	Phosphorylation	ESGASRFTVLFPSGT CCCCCCEEEECCCCC	18.39	23312004
418	Phosphorylation	RFTVLFPSGTPLPAR CEEEECCCCCCCCCC	48.22	28450419
420	Phosphorylation	TVLFPSGTPLPARRQ EEECCCCCCCCCCCH	26.45	21815630
456	Phosphorylation	KNSAKEETKFAQVVL CCCHHHHHHHHHHHH	32.33	-
457	Ubiquitination	NSAKEETKFAQVVLQ CCHHHHHHHHHHHHH	41.82	-
468	Ubiquitination	VVLQDLDKKENGLRD HHHHHHHHCCCCHHH	70.09	-
469	Acetylation	VLQDLDKKENGLRDI HHHHHHHCCCCHHHH	56.96	19814893
481	Phosphorylation	RDILAVLTMKRDGSL HHHHHHEEECCCCCE	17.66	20068231
487	Phosphorylation	LTMKRDGSLHVTCTD EEECCCCCEEEEEEC	21.42	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP7E_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP7E_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP7E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAF1_HUMAN	PAF1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.